DegronMD

Uniprot ID: O15550

Source protein: Lysine-specific demethylase 6A

Source gene: KDM6A

Class: DEG_SPOP_SBC_1

Location: 578:582

E3 ligase: SPOP

DEGRON score: 0.9564

ASA_SCORE: 70.54

COIL: 0.9056

CONS_SCORE: 0.265

DSS_SCORE: 0.4442

HELIX: 0.052

FCONS_SCORE: 1.058

RIG_SCORE: 0.7266

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S580N	TCGA-AP-A1E0	UCEC	TCGA	PCSTS	DEG_SPOP_SBC_1	0.7069
p.S580N	DO43154	UCEC	ICGC	PCSTS	DEG_SPOP_SBC_1	0.7069
p.S582A	TCGA-B5-A3FA	UCEC	TCGA	PCSTS	DEG_SPOP_SBC_1	0.7588
p.S582A	DO52402	UCEC	ICGC	PCSTS	DEG_SPOP_SBC_1	0.7588
p.F572C	TCGA-EA-A3HU	CESC	TCGA	PCSTS	DEG_SPOP_SBC_1	0.1667
p.F572C	DO6320	CESC	ICGC	PCSTS	DEG_SPOP_SBC_1	0.1667
p.T584M	SIDM00663	Melanoma	GDSC	PCSTS	DEG_SPOP_SBC_1	0.2778
p.I591V	SIDM00845	Burkitt's Lymphoma	GDSC	PCSTS	DEG_SPOP_SBC_1	0.0833
p.I591V	ACH-000786	Lymphoma	CCLE	PCSTS	DEG_SPOP_SBC_1	0.0833
p.I591V	ACH-000992	Head and Neck Cancer	CCLE	PCSTS	DEG_SPOP_SBC_1	0.0833
p.I591V	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PCSTS	DEG_SPOP_SBC_1	0.0833
p.N569D	SIDM01608	Endometrial Carcinoma	GDSC	PCSTS	DEG_SPOP_SBC_1	0.0833
p.N569D	ACH-000990	Endometrial/Uterine Cancer	CCLE	PCSTS	DEG_SPOP_SBC_1	0.0833
p.A574E	ACH-000520	Ovarian Cancer	CCLE	PCSTS	DEG_SPOP_SBC_1	0.2222
p.Q578P	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	PCSTS	DEG_SPOP_SBC_1	0.7035
p.Q578P	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PCSTS	DEG_SPOP_SBC_1	0.7035
p.I574V	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PCSTS	DEG_SPOP_SBC_1	0.2222
p.P584H	OVK-18	ovary	COSMIC	PCSTS	DEG_SPOP_SBC_1	0.2778
p.S582L	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PCSTS	DEG_SPOP_SBC_1	0.7667
p.S582L	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	PCSTS	DEG_SPOP_SBC_1	0.7667
p.I581V	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PCSTS	DEG_SPOP_SBC_1	0.7076
p.G577C	HEC-1	endometrium	COSMIC	PCSTS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15550	Lysine-specific demethylase 6A	DEG_SPOP_SBC_1	578:582	PCSTS	SPOP	0.9564	More...
P17813	Endoglin	DEG_SPOP_SBC_1	651:655	PCSTS	SPOP	0.9842	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	1480:1484	PCSTS	SPOP	0.5597	More...
Q96QF0	Rab-3A-interacting protein	DEG_SPOP_SBC_1	108:112	PCSTS	SPOP	0.9786	More...
Q9C0D0	Phosphatase and actin regulator 1	DEG_SPOP_SBC_1	335:339	PCSTS	SPOP	0.9483	More...
Q9P227	Rho GTPase-activating protein 23	DEG_SPOP_SBC_1	330:334	PCSTS	SPOP	0.9921	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons