DegronMD - Q9P227(ARHGAP23)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G366V	TCGA-5P-A9K6	KIRP	TCGA	GPGALVSPR	DEG_SIAH_1	366:374	Mutation altering degron motif	0.6421
p.R91H	TCGA-A3-3358	KIRC	TCGA	PRYRLEPMD	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.7133
p.R91H	DO16144	KIRC	ICGC	PRYRLEPMD	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.7133
p.A364T	TCGA-AA-3947	COAD	TCGA	GPGALVSPR	DEG_SIAH_1	366:374	Mutation rewiring degron network	0.2778
p.T359S	TCGA-CC-5264	LIHC	TCGA	GPGALVSPR	DEG_SIAH_1	366:374	Mutation rewiring degron network	0.1389
p.R374C	TCGA-EO-A22U	UCEC	TCGA	GPGALVSPR	DEG_SIAH_1	366:374	Mutation altering degron motif	0.719
p.R374C	SIDM00121	T-Lymphoblastic Leukemia	GDSC	GPGALVSPR	DEG_SIAH_1	366:374	Mutation altering degron motif	0.719
p.R327H	TCGA-FI-A2D0	UCEC	TCGA	PCSTS	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.25
p.E78D	TCGA-FI-A2D5	UCEC	TCGA	PRYRLEPMD	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.0556
p.E78D	DO36556	READ	ICGC	PRYRLEPMD	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.0556
p.E78D	DO41331	UCEC	ICGC	PRYRLEPMD	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.0556
p.I98V	TCGA-FI-A2D5	UCEC	TCGA	PRYRLEPMD	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.2778
p.A337T	TCGA-UD-AAC6	MESO	TCGA	PCSTS	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.25
p.R334H	DO225201	BRCA	ICGC	PCSTS	DEG_SPOP_SBC_1	330:334	Mutation altering degron motif	0.8244
p.P377L	DO223732	CESC	ICGC	GPGALVSPR	DEG_SIAH_1	366:374	Mutation rewiring degron network	0.25
p.P377L	DO233203	GACA	ICGC	GPGALVSPR	DEG_SIAH_1	366:374	Mutation rewiring degron network	0.25
p.R327C	DO227802	COCA	ICGC	PCSTS	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.25
p.R86H	DO233766	GACA	ICGC	PRYRLEPMD	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.2778
p.R335Q	DO233942	GACA	ICGC	PCSTS	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.3056
p.L320H	DO228403	MALY	ICGC	PCSTS	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.0556
p.R373K	DO222572	MELA	ICGC	GPGALVSPR	DEG_SIAH_1	366:374	Mutation altering degron motif	0.7237
p.A341V	DO227676	PBCA	ICGC	PCSTS	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.1389
p.D1350Y	DO232224	PBCA	ICGC	ASSSS	DEG_SPOP_SBC_1	1347:1351	Mutation altering degron motif	0.7325
p.R98C	DO223282	UCEC	ICGC	PRYRLEPMD	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.2778
p.E79K	DO42280	UCEC	ICGC	PRYRLEPMD	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.0833
p.G324S	DO41871	UCEC	ICGC	PCSTS	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.1667
p.A383T	DO42673	UCEC	ICGC	GPGALVSPR	DEG_SIAH_1	366:374	Mutation rewiring degron network	0.0833
p.R89W	SIDM02072	Colorectal Carcinoma	GDSC	PRYRLEPMD	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.8634
p.C378R	SIDM01293	Colorectal Carcinoma	GDSC	GPGALVSPR	DEG_SIAH_1	366:374	Mutation rewiring degron network	0.2222
p.A381V	SIDM02015	Colorectal Carcinoma	GDSC	GPGALVSPR	DEG_SIAH_1	366:374	Mutation rewiring degron network	0.1389
p.A381V	ACH-002059	Leukemia	CCLE	GPGALVSPR	DEG_SIAH_1	366:374	Mutation rewiring degron network	0.1389
p.E363K	ACH-000894	Lung Cancer	CCLE	GPGALVSPR	DEG_SIAH_1	366:374	Mutation rewiring degron network	0.25
p.R384H	ACH-000939	Sarcoma	CCLE	GPGALVSPR	DEG_SIAH_1	366:374	Mutation rewiring degron network	0.0556
p.D1444E	ACH-000985	Colon/Colorectal Cancer	CCLE	DSGLSS	DEG_SCF_TRCP1_1	1444:1449	Mutation altering degron motif	0.6758
p.A1455V	ACH-000996	Endometrial/Uterine Cancer	CCLE	DSGLSS	DEG_SCF_TRCP1_1	1444:1449	Mutation rewiring degron network	0.1667
p.P88R	ACH-001458	Colon/Colorectal Cancer	CCLE	PRYRLEPMD	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.6401

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARHGAP23

UniProt ID: Q9P227

Entrez ID: 57636

Protein name: Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ARHGAP23 in