Degron: ASSSS
69.94
0.8456
0.2533
0.8361
0.1196
1.0324
0.4814
Degron related mutations and impact score
| Mutation | Sample | Cancer | Dataset | Degron | Degron class | Impact score |
| p.D1350Y | DO232224 | PBCA | ICGC | ASSSS | DEG_SPOP_SBC_1 | 0.7325 |
Drug responses associated with ARHGAP23 mutations
| Sample | Cancer | Mutation (In Degron?) | Dataset | Drug | IC50 |
All proteins holding degron of ASSSS
| Uniprot ID | Source protein | Degron class | Location | Hit | E3 ligase | Degron score | Detail |
| A0JLT2 | Mediator of RNA polymerase II transcription subunit 19 | DEG_SPOP_SBC_1 | 237:241 | ASSSS | SPOP | 0.692 | More... |
| A2VDJ0 | Transmembrane protein 131-like | DEG_SPOP_SBC_1 | 909:913 | ASSSS | SPOP | 0.7658 | More... |
| A4D161 | Protein FAM221A | DEG_SPOP_SBC_1 | 237:241 | ASSSS | SPOP | 0.9261 | More... |
| O00571 | ATP-dependent RNA helicase DDX3X | DEG_SPOP_SBC_1 | 608:612 | ASSSS | SPOP | 0.9984 | More... |
| O14492 | SH2B adapter protein 2 | DEG_SPOP_SBC_1 | 566:570 | ASSSS | SPOP | 0.9979 | More... |
| O14492 | SH2B adapter protein 2 | DEG_SPOP_SBC_1 | 571:575 | ASSSS | SPOP | 0.9977 | More... |
| O14497 | AT-rich interactive domain-containing protein 1A | DEG_SPOP_SBC_1 | 259:263 | ASSSS | SPOP | 0.8451 | More... |
| O15018 | PDZ domain-containing protein 2 | DEG_SPOP_SBC_1 | 2168:2172 | ASSSS | SPOP | 0.9964 | More... |
| O15047 | Histone-lysine N-methyltransferase SETD1A | DEG_SPOP_SBC_1 | 339:343 | ASSSS | SPOP | 0.9582 | More... |
| O15054 | Lysine-specific demethylase 6B | DEG_SPOP_SBC_1 | 865:869 | ASSSS | SPOP | 0.9886 | More... |
| O15265 | Ataxin-7 | DEG_SPOP_SBC_1 | 214:218 | ASSSS | SPOP | 0.9963 | More... |
| O15534 | Period circadian protein homolog 1 | DEG_SPOP_SBC_1 | 652:656 | ASSSS | SPOP | 0.9988 | More... |
| O43189 | PHD finger protein 1 | DEG_SPOP_SBC_1 | 495:499 | ASSSS | SPOP | 0.9504 | More... |
| O43474 | Krueppel-like factor 4 | DEG_SPOP_SBC_1 | 130:134 | ASSSS | SPOP | 0.7205 | More... |
| O75197 | Low-density lipoprotein receptor-related protein 5 | DEG_SPOP_SBC_1 | 1481:1485 | ASSSS | SPOP | 0.9948 | More... |
| O75581 | Low-density lipoprotein receptor-related protein 6 | DEG_SPOP_SBC_1 | 1468:1472 | ASSSS | SPOP | 0.9959 | More... |
| P08047 | Transcription factor Sp1 | DEG_SPOP_SBC_1 | 315:319 | ASSSS | SPOP | 0.8981 | More... |
| P08069 | Insulin-like growth factor 1 receptor | DEG_SPOP_SBC_1 | 1309:1313 | ASSSS | SPOP | 0.9782 | More... |
| P11308 | Transcriptional regulator ERG | DEG_SPOP_SBC_1 | 35:39 | ASSSS | SPOP | 0.992 | More... |
| P25440 | Bromodomain-containing protein 2 | DEG_SPOP_SBC_1 | 776:780 | ASSSS | SPOP | 0.9929 | More... |
| P31249 | Homeobox protein Hox-D3 | DEG_SPOP_SBC_1 | 149:153 | ASSSS | SPOP | 0.9801 | More... |
| P32242 | Homeobox protein OTX1 | DEG_SPOP_SBC_1 | 136:140 | ASSSS | SPOP | 0.9354 | More... |
| P32242 | Homeobox protein OTX1 | DEG_SPOP_SBC_1 | 142:146 | ASSSS | SPOP | 0.9168 | More... |
| P34925 | Tyrosine-protein kinase RYK | DEG_SPOP_SBC_1 | 266:270 | ASSSS | SPOP | 0.902 | More... |
| P43356 | Melanoma-associated antigen 2 | DEG_SPOP_SBC_1 | 39:43 | ASSSS | SPOP | 0.94 | More... |
| P43365 | Melanoma-associated antigen 12 | DEG_SPOP_SBC_1 | 39:43 | ASSSS | SPOP | 0.7923 | More... |
| P48995 | Short transient receptor potential channel 1 | DEG_SPOP_SBC_1 | 14:18 | ASSSS | SPOP | 0.9293 | More... |
| P49790 | Nuclear pore complex protein Nup153 | DEG_SPOP_SBC_1 | 772:776 | ASSSS | SPOP | 0.808 | More... |
| P50548 | ETS domain-containing transcription factor ERF | DEG_SPOP_SBC_1 | 364:368 | ASSSS | SPOP | 0.9956 | More... |
| P51617 | Interleukin-1 receptor-associated kinase 1 | DEG_SPOP_SBC_1 | 651:655 | ASSSS | SPOP | 0.9942 | More... |
| P54132 | Bloom syndrome protein | DEG_SPOP_SBC_1 | 311:315 | ASSSS | SPOP | 0.9518 | More... |
| P55198 | Protein AF-17 | DEG_SPOP_SBC_1 | 278:282 | ASSSS | SPOP | 0.9963 | More... |
| P55198 | Protein AF-17 | DEG_SPOP_SBC_1 | 327:331 | ASSSS | SPOP | 0.9982 | More... |
| P78424 | POU domain, class 6, transcription factor 2 | DEG_SPOP_SBC_1 | 447:451 | ASSSS | SPOP | 0.9845 | More... |
| P80192 | Mitogen-activated protein kinase kinase kinase 9 | DEG_SPOP_SBC_1 | 1037:1041 | ASSSS | SPOP | 0.9687 | More... |
| Q02388 | Collagen alpha-1 | DEG_SPOP_SBC_1 | 697:701 | ASSSS | SPOP | 0.9041 | More... |
| Q03164 | Histone-lysine N-methyltransferase 2A | DEG_SPOP_SBC_1 | 89:93 | ASSSS | SPOP | 0.9982 | More... |
| Q03164 | Histone-lysine N-methyltransferase 2A | DEG_SPOP_SBC_1 | 3335:3339 | ASSSS | SPOP | 0.7076 | More... |
| Q04727 | Transducin-like enhancer protein 4 | DEG_SPOP_SBC_1 | 297:301 | ASSSS | SPOP | 0.9988 | More... |
| Q08945 | FACT complex subunit SSRP1 | DEG_SPOP_SBC_1 | 501:505 | ASSSS | SPOP | 0.9979 | More... |
| Q08AD1 | Calmodulin-regulated spectrin-associated protein 2 | DEG_SPOP_SBC_1 | 689:693 | ASSSS | SPOP | 0.9974 | More... |
| Q12791 | Calcium-activated potassium channel subunit alpha-1 | DEG_SPOP_SBC_1 | 38:42 | ASSSS | SPOP | 0.9676 | More... |
| Q12888 | TP53-binding protein 1 | DEG_SPOP_SBC_1 | 1641:1645 | ASSSS | SPOP | 0.9831 | More... |
| Q12923 | Tyrosine-protein phosphatase non-receptor type 13 | DEG_SPOP_SBC_1 | 1745:1749 | ASSSS | SPOP | 0.9253 | More... |
| Q12947 | Forkhead box protein F2 | DEG_SPOP_SBC_1 | 57:61 | ASSSS | SPOP | 0.9363 | More... |
| Q13796 | Protein Shroom2 | DEG_SPOP_SBC_1 | 149:153 | ASSSS | SPOP | 0.9377 | More... |
| Q14005 | Pro-interleukin-16 [Cleaved into: Interleukin-16 | DEG_SPOP_SBC_1 | 832:836 | ASSSS | SPOP | 0.9965 | More... |
| Q15648 | Mediator of RNA polymerase II transcription subunit 1 | DEG_SPOP_SBC_1 | 1268:1272 | ASSSS | SPOP | 0.9827 | More... |
| Q16891 | MICOS complex subunit MIC60 | DEG_SPOP_SBC_1 | 189:193 | ASSSS | SPOP | 0.8148 | More... |
| Q2Q1W2 | E3 ubiquitin-protein ligase TRIM71 | DEG_SPOP_SBC_1 | 31:35 | ASSSS | SPOP | 0.8838 | More... |
| Q3L8U1 | Chromodomain-helicase-DNA-binding protein 9 | DEG_SPOP_SBC_1 | 2174:2178 | ASSSS | SPOP | 0.9639 | More... |
| Q569K4 | Zinc finger protein 385B | DEG_SPOP_SBC_1 | 231:235 | ASSSS | SPOP | 0.8099 | More... |
| Q5JU85 | IQ motif and SEC7 domain-containing protein 2 | DEG_SPOP_SBC_1 | 1230:1234 | ASSSS | SPOP | 0.8255 | More... |
| Q5T4S7 | E3 ubiquitin-protein ligase UBR4 | DEG_SPOP_SBC_1 | 3345:3349 | ASSSS | SPOP | 0.9691 | More... |
| Q5T6F2 | Ubiquitin-associated protein 2 | DEG_SPOP_SBC_1 | 777:781 | ASSSS | SPOP | 0.9765 | More... |
| Q5TCX8 | Mitogen-activated protein kinase kinase kinase 21 | DEG_SPOP_SBC_1 | 25:29 | ASSSS | SPOP | 0.97 | More... |
| Q5TCY1 | Tau-tubulin kinase 1 | DEG_SPOP_SBC_1 | 1109:1113 | ASSSS | SPOP | 0.9757 | More... |
| Q5VT06 | Centrosome-associated protein 350 | DEG_SPOP_SBC_1 | 708:712 | ASSSS | SPOP | 0.9973 | More... |
| Q5VT52 | Regulation of nuclear pre-mRNA domain-containing protein 2 | DEG_SPOP_SBC_1 | 12:16 | ASSSS | SPOP | 0.9241 | More... |
| Q5VTR2 | E3 ubiquitin-protein ligase BRE1A | DEG_SPOP_SBC_1 | 163:167 | ASSSS | SPOP | 0.5674 | More... |
| Q5VV67 | Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 | DEG_SPOP_SBC_1 | 1440:1444 | ASSSS | SPOP | 0.8903 | More... |
| Q685J3 | Mucin-17 | DEG_SPOP_SBC_1 | 548:552 | ASSSS | SPOP | 0.9987 | More... |
| Q685J3 | Mucin-17 | DEG_SPOP_SBC_1 | 607:611 | ASSSS | SPOP | 0.9585 | More... |
| Q685J3 | Mucin-17 | DEG_SPOP_SBC_1 | 1079:1083 | ASSSS | SPOP | 0.9475 | More... |
| Q6DJT9 | Zinc finger protein PLAG1 | DEG_SPOP_SBC_1 | 376:380 | ASSSS | SPOP | 0.9452 | More... |
| Q6ZN04 | RNA-binding protein MEX3B | DEG_SPOP_SBC_1 | 404:408 | ASSSS | SPOP | 0.8445 | More... |
| Q6ZUT1 | Uncharacterized protein NKAPD1 | DEG_SPOP_SBC_1 | 234:238 | ASSSS | SPOP | 0.7532 | More... |
| Q7Z3H0 | Photoreceptor ankyrin repeat protein | DEG_SPOP_SBC_1 | 407:411 | ASSSS | SPOP | 0.9925 | More... |
| Q7Z4V5 | Hepatoma-derived growth factor-related protein 2 | DEG_SPOP_SBC_1 | 254:258 | ASSSS | SPOP | 0.9555 | More... |
| Q7Z5J4 | Retinoic acid-induced protein 1 | DEG_SPOP_SBC_1 | 1631:1635 | ASSSS | SPOP | 0.9194 | More... |
| Q8IVL1 | Neuron navigator 2 | DEG_SPOP_SBC_1 | 1411:1415 | ASSSS | SPOP | 0.9427 | More... |
| Q8IVW6 | AT-rich interactive domain-containing protein 3B | DEG_SPOP_SBC_1 | 532:536 | ASSSS | SPOP | 0.9828 | More... |
| Q8IXF0 | Neuronal PAS domain-containing protein 3 | DEG_SPOP_SBC_1 | 233:237 | ASSSS | SPOP | 0.8805 | More... |
| Q8IXK0 | Polyhomeotic-like protein 2 | DEG_SPOP_SBC_1 | 23:27 | ASSSS | SPOP | 0.9155 | More... |
| Q8IXZ2 | Zinc finger CCCH domain-containing protein 3 | DEG_SPOP_SBC_1 | 386:390 | ASSSS | SPOP | 0.9761 | More... |
| Q8IXZ2 | Zinc finger CCCH domain-containing protein 3 | DEG_SPOP_SBC_1 | 872:876 | ASSSS | SPOP | 0.9634 | More... |
| Q8IY26 | Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6 | DEG_SPOP_SBC_1 | 17:21 | ASSSS | SPOP | 0.9988 | More... |
| Q8N6K0 | Testis-expressed protein 29 | DEG_SPOP_SBC_1 | 108:112 | ASSSS | SPOP | 0.9978 | More... |
| Q8TCU4 | Alstrom syndrome protein 1 | DEG_SPOP_SBC_1 | 1891:1895 | ASSSS | SPOP | 0.9753 | More... |
| Q8TCU4 | Alstrom syndrome protein 1 | DEG_SPOP_SBC_1 | 3245:3249 | ASSSS | SPOP | 0.9886 | More... |
| Q8WWN9 | Interactor protein for cytohesin exchange factors 1 | DEG_SPOP_SBC_1 | 183:187 | ASSSS | SPOP | 0.996 | More... |
| Q8WWX8 | Sodium/myo-inositol cotransporter 2 | DEG_SPOP_SBC_1 | 587:591 | ASSSS | SPOP | 0.9469 | More... |
| Q8WXH0 | Nesprin-2 | DEG_SPOP_SBC_1 | 4155:4159 | ASSSS | SPOP | 0.9945 | More... |
| Q92734 | Protein TFG | DEG_SPOP_SBC_1 | 211:215 | ASSSS | SPOP | 0.9523 | More... |
| Q92794 | Histone acetyltransferase KAT6A | DEG_SPOP_SBC_1 | 375:379 | ASSSS | SPOP | 0.9985 | More... |
| Q92800 | Histone-lysine N-methyltransferase EZH1 | DEG_SPOP_SBC_1 | 397:401 | ASSSS | SPOP | 0.9923 | More... |
| Q92833 | Protein Jumonji | DEG_SPOP_SBC_1 | 1235:1239 | ASSSS | SPOP | 0.9876 | More... |
| Q92833 | Protein Jumonji | DEG_SPOP_SBC_1 | 1242:1246 | ASSSS | SPOP | 0.8412 | More... |
| Q969Z3 | Mitochondrial amidoxime reducing component 2 | DEG_SPOP_SBC_1 | 3:7 | ASSSS | SPOP | 0.7836 | More... |
| Q96L96 | Alpha-protein kinase 3 | DEG_SPOP_SBC_1 | 767:771 | ASSSS | SPOP | 0.9904 | More... |
| Q96QT6 | PHD finger protein 12 | DEG_SPOP_SBC_1 | 928:932 | ASSSS | SPOP | 0.8699 | More... |
| Q9BZS1 | Forkhead box protein P3 | DEG_SPOP_SBC_1 | 56:60 | ASSSS | SPOP | 0.8871 | More... |
| Q9C0D6 | FH2 domain-containing protein 1 | DEG_SPOP_SBC_1 | 719:723 | ASSSS | SPOP | 0.867 | More... |
| Q9H7S9 | Zinc finger protein 703 | DEG_SPOP_SBC_1 | 211:215 | ASSSS | SPOP | 0.9972 | More... |
| Q9HCG8 | Pre-mRNA-splicing factor CWC22 homolog | DEG_SPOP_SBC_1 | 674:678 | ASSSS | SPOP | 0.9842 | More... |
| Q9HDB5 | Neurexin-3-beta | DEG_SPOP_SBC_1 | 480:484 | ASSSS | SPOP | 0.9795 | More... |
| Q9NPF5 | DNA methyltransferase 1-associated protein 1 | DEG_SPOP_SBC_1 | 455:459 | ASSSS | SPOP | 0.7946 | More... |
| Q9NPG3 | Ubinuclein-1 | DEG_SPOP_SBC_1 | 867:871 | ASSSS | SPOP | 0.9938 | More... |
| Q9NSI6 | Bromodomain and WD repeat-containing protein 1 | DEG_SPOP_SBC_1 | 1544:1548 | ASSSS | SPOP | 0.9686 | More... |
| Q9NTI5 | Sister chromatid cohesion protein PDS5 homolog B | DEG_SPOP_SBC_1 | 1158:1162 | ASSSS | SPOP | 0.9447 | More... |
| Q9NY27 | Serine/threonine-protein phosphatase 4 regulatory subunit 2 | DEG_SPOP_SBC_1 | 278:282 | ASSSS | SPOP | 0.9992 | More... |
| Q9P1Z0 | Zinc finger and BTB domain-containing protein 4 | DEG_SPOP_SBC_1 | 101:105 | ASSSS | SPOP | 0.9956 | More... |
| Q9P286 | Serine/threonine-protein kinase PAK 5 | DEG_SPOP_SBC_1 | 222:226 | ASSSS | SPOP | 0.7523 | More... |
| Q9UBN1 | Voltage-dependent calcium channel gamma-4 subunit | DEG_SPOP_SBC_1 | 224:228 | ASSSS | SPOP | 0.7395 | More... |
| Q9UFE4 | Coiled-coil domain-containing protein 39 | DEG_SPOP_SBC_1 | 927:931 | ASSSS | SPOP | 0.9527 | More... |
| Q9UGU0 | Transcription factor 20 | DEG_SPOP_SBC_1 | 239:243 | ASSSS | SPOP | 0.9888 | More... |
| Q9UJ98 | Cohesin subunit SA-3 | DEG_SPOP_SBC_1 | 18:22 | ASSSS | SPOP | 0.9571 | More... |
| Q9UKB5 | Adherens junction-associated protein 1 | DEG_SPOP_SBC_1 | 131:135 | ASSSS | SPOP | 0.9942 | More... |
| Q9ULI2 | Beta-citrylglutamate synthase B | DEG_SPOP_SBC_1 | 346:350 | ASSSS | SPOP | 0.9949 | More... |
| Q9UPA5 | Protein bassoon | DEG_SPOP_SBC_1 | 2649:2653 | ASSSS | SPOP | 0.9177 | More... |
| Q9UPS6 | Histone-lysine N-methyltransferase SETD1B | DEG_SPOP_SBC_1 | 1049:1053 | ASSSS | SPOP | 0.9758 | More... |
| Q9Y446 | Plakophilin-3 | DEG_SPOP_SBC_1 | 219:223 | ASSSS | SPOP | 0.9994 | More... |
| Q9Y467 | Sal-like protein 2 | DEG_SPOP_SBC_1 | 255:259 | ASSSS | SPOP | 0.9956 | More... |
| Q9Y4C0 | Neurexin-3 | DEG_SPOP_SBC_1 | 1486:1490 | ASSSS | SPOP | 0.9784 | More... |
| Q9Y4X4 | Krueppel-like factor 12 | DEG_SPOP_SBC_1 | 136:140 | ASSSS | SPOP | 0.9685 | More... |
| Q9Y566 | SH3 and multiple ankyrin repeat domains protein 1 | DEG_SPOP_SBC_1 | 1973:1977 | ASSSS | SPOP | 0.9913 | More... |
| Q9Y5X1 | Sorting nexin-9 | DEG_SPOP_SBC_1 | 196:200 | ASSSS | SPOP | 0.9833 | More... |
| A1L020 | RNA-binding protein MEX3A | DEG_SPOP_SBC_1 | 408:412 | ASSSS | SPOP | 0.9395 | More... |
| Q2KJY2 | Kinesin-like protein KIF26B | DEG_SPOP_SBC_1 | 1648:1652 | ASSSS | SPOP | 0.861 | More... |
| Q6T4P5 | Phospholipid phosphatase-related protein type 3 | DEG_SPOP_SBC_1 | 557:561 | ASSSS | SPOP | 0.9987 | More... |
| Q86UZ6 | Zinc finger and BTB domain-containing protein 46 | DEG_SPOP_SBC_1 | 148:152 | ASSSS | SPOP | 0.8507 | More... |
| Q8N143 | B-cell CLL/lymphoma 6 member B protein | DEG_SPOP_SBC_1 | 233:237 | ASSSS | SPOP | 0.8845 | More... |
| Q9ULI4 | Kinesin-like protein KIF26A | DEG_SPOP_SBC_1 | 733:737 | ASSSS | SPOP | 0.9903 | More... |
| Q6NT52 | Choriogonadotropin subunit beta variant 2 | DEG_SPOP_SBC_1 | 135:139 | ASSSS | SPOP | 0.9986 | More... |
| Q9P227 | Rho GTPase-activating protein 23 | DEG_SPOP_SBC_1 | 1347:1351 | ASSSS | SPOP | 0.9739 | More... |
| A6NNC1 | Putative POM121-like protein 1-like | DEG_SPOP_SBC_1 | 392:396 | ASSSS | SPOP | 0.9991 | More... |
| A6NNC1 | Putative POM121-like protein 1-like | DEG_SPOP_SBC_1 | 666:670 | ASSSS | SPOP | 0.9988 | More... |
| O15480 | Melanoma-associated antigen B3 | DEG_SPOP_SBC_1 | 340:344 | ASSSS | SPOP | 0.9907 | More... |
| Q69YW2 | Protein stum homolog | DEG_SPOP_SBC_1 | 25:29 | ASSSS | SPOP | 0.8246 | More... |
| Q6PEV8 | Protein FAM199X | DEG_SPOP_SBC_1 | 282:286 | ASSSS | SPOP | 0.9905 | More... |
| Q86VQ1 | Glucocorticoid-induced transcript 1 protein | DEG_SPOP_SBC_1 | 4:8 | ASSSS | SPOP | 0.8704 | More... |
| Q9NQR7 | Coiled-coil domain-containing protein 177 | DEG_SPOP_SBC_1 | 250:254 | ASSSS | SPOP | 0.9585 | More... |
| Q9NUC0 | SERTA domain-containing protein 4 | DEG_SPOP_SBC_1 | 222:226 | ASSSS | SPOP | 0.8625 | More... |
| Q9NX31 | Oxidative stress-responsive serine-rich protein 1 | DEG_SPOP_SBC_1 | 99:103 | ASSSS | SPOP | 0.9942 | More... |
| A8MZG2 | Uncharacterized protein C16orf90 | DEG_SPOP_SBC_1 | 134:138 | ASSSS | SPOP | 0.7432 | More... |