DegronMD - Q9Y446(PKP3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S223C	TCGA-BR-8678	STAD	TCGA	ASSSS	DEG_SPOP_SBC_1	219:223	Mutation altering degron motif	0.7541
p.S223C	DO47957	STAD	ICGC	ASSSS	DEG_SPOP_SBC_1	219:223	Mutation altering degron motif	0.7541
p.A205T	TCGA-D7-A6EY	STAD	TCGA	AATST	DEG_SPOP_SBC_1	205:209	Mutation altering degron motif	0.7139
p.A205T	DO50118	STAD	ICGC	AATST	DEG_SPOP_SBC_1	205:209	Mutation altering degron motif	0.7139
p.G227E	TCGA-EE-A2A2	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	219:223	Mutation rewiring degron network	0.2222
p.G227E	DO37583	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	219:223	Mutation rewiring degron network	0.2222
p.G228R	TCGA-FW-A3R5	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	219:223	Mutation rewiring degron network	0.1944
p.G228R	DO37406	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	219:223	Mutation rewiring degron network	0.1944
p.G228R	SIDM00333	Endometrial Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	219:223	Mutation rewiring degron network	0.1944
p.G228R	ACH-000988	Endometrial/Uterine Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	219:223	Mutation rewiring degron network	0.1944
p.G228R	MFE-319	endometrium	COSMIC	ASSSS	DEG_SPOP_SBC_1	219:223	Mutation rewiring degron network	0.1944
p.P204H	TCGA-HR-A2OH	SKCM	TCGA	AATST	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.3056
p.P204H	DO37774	SKCM	ICGC	AATST	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.3056
p.Y195C	TCGA-O2-A52N	LUSC	TCGA	AATST	DEG_SPOP_SBC_1	205:209	Mutation blocking phosphorylation signal	0.5
p.Y195C	DO219217	LUSC	ICGC	AATST	DEG_SPOP_SBC_1	205:209	Mutation blocking phosphorylation signal	0.5
p.R217H	DO228893	LICA	ICGC	AATST	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.1111
p.R217H	DO228893	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	219:223	Mutation rewiring degron network	0.2778
p.A206T	DO220877	MELA	ICGC	AATST	DEG_SPOP_SBC_1	205:209	Mutation altering degron motif	0.6028
p.Q201H	DO229148	THCA	ICGC	AATST	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.2222
p.L202M	DO229221	THCA	ICGC	AATST	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.25
p.E233K	SIDM00318	Kidney Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	219:223	Mutation rewiring degron network	0.0556
p.E233K	SIDM00554	Ovarian Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	219:223	Mutation rewiring degron network	0.0556
p.E233K	ACH-000484	Kidney Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	219:223	Mutation rewiring degron network	0.0556
p.E233K	ACH-000524	Ovarian Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	219:223	Mutation rewiring degron network	0.0556
p.S223F	SIDM00333	Endometrial Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	219:223	Mutation altering degron motif	0.7982
p.S223F	ACH-000988	Endometrial/Uterine Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	219:223	Mutation altering degron motif	0.7982
p.S223F	MFE-319	endometrium	COSMIC	ASSSS	DEG_SPOP_SBC_1	219:223	Mutation altering degron motif	0.7982
p.A206S	SIDM00094	Kidney Carcinoma	GDSC	AATST	DEG_SPOP_SBC_1	205:209	Mutation altering degron motif	0.6477
p.A206S	ACH-002199	Kidney Cancer	CCLE	AATST	DEG_SPOP_SBC_1	205:209	Mutation altering degron motif	0.6477
p.A206S	SN12C	kidney	COSMIC	AATST	DEG_SPOP_SBC_1	205:209	Mutation altering degron motif	0.6477
p.A205V	SIDM00220	Ovarian Carcinoma	GDSC	AATST	DEG_SPOP_SBC_1	205:209	Mutation altering degron motif	0.5825
p.A205V	ACH-000962	Ovarian Cancer	CCLE	AATST	DEG_SPOP_SBC_1	205:209	Mutation altering degron motif	0.5825
p.A205V	ACH-001145	Ovarian Cancer	CCLE	AATST	DEG_SPOP_SBC_1	205:209	Mutation altering degron motif	0.5825
p.A205V	OC-314	ovary	COSMIC	AATST	DEG_SPOP_SBC_1	205:209	Mutation altering degron motif	0.5825
p.G227V	SIDM00823	Colorectal Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	219:223	Mutation rewiring degron network	0.2222
p.G227V	ACH-000253	Colon/Colorectal Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	219:223	Mutation rewiring degron network	0.2222

Kaplan plot for PKP3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PKP3

UniProt ID: Q9Y446

Entrez ID: 11187

Protein name: Plakophilin-3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PKP3 in