DegronMD

Uniprot ID: Q9Y446

Source protein: Plakophilin-3

Source gene: PKP3

Class: DEG_SPOP_SBC_1

Location: 205:209

E3 ligase: SPOP

DEGRON score: 0.9186

ASA_SCORE: 58.08

COIL: 0.6802

CONS_SCORE: 0.6145

DSS_SCORE: 0.3314

HELIX: 0.2892

FCONS_SCORE: 0.95

RIG_SCORE: 0.7675

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A205T	TCGA-D7-A6EY	STAD	TCGA	AATST	DEG_SPOP_SBC_1	0.7139
p.A205T	DO50118	STAD	ICGC	AATST	DEG_SPOP_SBC_1	0.7139
p.P204H	TCGA-HR-A2OH	SKCM	TCGA	AATST	DEG_SPOP_SBC_1	0.3056
p.P204H	DO37774	SKCM	ICGC	AATST	DEG_SPOP_SBC_1	0.3056
p.Y195C	TCGA-O2-A52N	LUSC	TCGA	AATST	DEG_SPOP_SBC_1	0.5
p.Y195C	DO219217	LUSC	ICGC	AATST	DEG_SPOP_SBC_1	0.5
p.R217H	DO228893	LICA	ICGC	AATST	DEG_SPOP_SBC_1	0.1111
p.A206T	DO220877	MELA	ICGC	AATST	DEG_SPOP_SBC_1	0.6028
p.Q201H	DO229148	THCA	ICGC	AATST	DEG_SPOP_SBC_1	0.2222
p.L202M	DO229221	THCA	ICGC	AATST	DEG_SPOP_SBC_1	0.25
p.A206S	SIDM00094	Kidney Carcinoma	GDSC	AATST	DEG_SPOP_SBC_1	0.6477
p.A206S	ACH-002199	Kidney Cancer	CCLE	AATST	DEG_SPOP_SBC_1	0.6477
p.A206S	SN12C	kidney	COSMIC	AATST	DEG_SPOP_SBC_1	0.6477
p.A205V	SIDM00220	Ovarian Carcinoma	GDSC	AATST	DEG_SPOP_SBC_1	0.5825
p.A205V	ACH-000962	Ovarian Cancer	CCLE	AATST	DEG_SPOP_SBC_1	0.5825
p.A205V	ACH-001145	Ovarian Cancer	CCLE	AATST	DEG_SPOP_SBC_1	0.5825
p.A205V	OC-314	ovary	COSMIC	AATST	DEG_SPOP_SBC_1	0.5825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75056	Syndecan-3	DEG_SPOP_SBC_1	167:171	AATST	SPOP	0.9748	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	594:598	AATST	SPOP	0.737	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1401:1405	AATST	SPOP	0.9715	More...
Q05209	Tyrosine-protein phosphatase non-receptor type 12	DEG_SPOP_SBC_1	633:637	AATST	SPOP	0.9815	More...
Q4KMQ1	Taperin	DEG_SPOP_SBC_1	289:293	AATST	SPOP	0.9965	More...
Q6W2J9	BCL-6 corepressor	DEG_SPOP_SBC_1	104:108	AATST	SPOP	0.9528	More...
Q86Z02	Homeodomain-interacting protein kinase 1	DEG_SPOP_SBC_1	95:99	AATST	SPOP	0.9812	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11752:11756	AATST	SPOP	0.9954	More...
Q96BD5	PHD finger protein 21A	DEG_SPOP_SBC_1	655:659	AATST	SPOP	0.9845	More...
Q96FS4	Signal-induced proliferation-associated protein 1	DEG_SPOP_SBC_1	82:86	AATST	SPOP	0.9975	More...
Q9BVL2	Nucleoporin p58/p45	DEG_SPOP_SBC_1	206:210	AATST	SPOP	0.9912	More...
Q9NZN1	Interleukin-1 receptor accessory protein-like 1	DEG_SPOP_SBC_1	594:598	AATST	SPOP	0.6429	More...
Q9ULV3	Cip1-interacting zinc finger protein	DEG_SPOP_SBC_1	581:585	AATST	SPOP	0.9621	More...
Q9Y446	Plakophilin-3	DEG_SPOP_SBC_1	205:209	AATST	SPOP	0.9186	More...
Q9Y6Y8	SEC23-interacting protein	DEG_SPOP_SBC_1	718:722	AATST	SPOP	0.6755	More...
Q8N3X1	Formin-binding protein 4	DEG_SPOP_SBC_1	181:185	AATST	SPOP	0.7939	More...
Q86XN7	Proline and serine-rich protein 1	DEG_SPOP_SBC_1	732:736	AATST	SPOP	0.9872	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons