DegronMD - O75056(SDC3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S131C	TCGA-55-A48Y	LUAD	TCGA	PVGTPFEE	DEG_SCF_FBW7_2	121:128	Mutation rewiring degron network	0.25
p.R133H	TCGA-A5-A0GA	UCEC	TCGA	PVGTPFEE	DEG_SCF_FBW7_2	121:128	Mutation rewiring degron network	0.1944
p.G123C	TCGA-EE-A29X	SKCM	TCGA	PVGTPFEE	DEG_SCF_FBW7_2	121:128	Mutation altering degron motif	0.6489
p.T129I	DO51926	BLCA	ICGC	PVGTPFEE	DEG_SCF_FBW7_2	121:128	Mutation rewiring degron network	0.3056
p.P174L	DO222955	BTCA	ICGC	AATST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.25
p.P174L	DO228326	MALY	ICGC	AATST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.25
p.P174L	SIDM00121	T-Lymphoblastic Leukemia	GDSC	AATST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.25
p.P174L	ACH-001738	Leukemia	CCLE	AATST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.25
p.T120I	DO229005	COCA	ICGC	PVGTPFEE	DEG_SCF_FBW7_2	121:128	Mutation rewiring degron network	0.3056
p.A123V	DO233634	GACA	ICGC	PVGTPFEE	DEG_SCF_FBW7_2	121:128	Mutation altering degron motif	0.6936
p.T135I	DO220885	MELA	ICGC	PVGTPFEE	DEG_SCF_FBW7_2	121:128	Mutation rewiring degron network	0.1389
p.P137L	DO220906	MELA	ICGC	PVGTPFEE	DEG_SCF_FBW7_2	121:128	Mutation rewiring degron network	0.0833
p.A171V	DO38887	STAD	ICGC	AATST	DEG_SPOP_SBC_1	167:171	Mutation altering degron motif	0.6936
p.A128T	DO39288	THCA	ICGC	PVGTPFEE	DEG_SCF_FBW7_2	121:128	Mutation altering degron motif	0.7139
p.T178I	SIDM00582	Pancreatic Carcinoma	GDSC	AATST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1389
p.T178I	SIDM00338	Acute Myeloid Leukemia	GDSC	AATST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1389
p.T178I	SIDM00584	Osteosarcoma	GDSC	AATST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1389
p.T178I	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	AATST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1389
p.T178I	SIDM00239	Kidney Carcinoma	GDSC	AATST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1389
p.T178I	SIDM00018	Acute Myeloid Leukemia	GDSC	AATST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1389
p.T117M	SIDM00683	Prostate Carcinoma	GDSC	PVGTPFEE	DEG_SCF_FBW7_2	121:128	Mutation rewiring degron network	0.2222
p.S131T	SIDM00789	Colorectal Carcinoma	GDSC	PVGTPFEE	DEG_SCF_FBW7_2	121:128	Mutation rewiring degron network	0.25
p.S131T	ACH-000997	Colon/Colorectal Cancer	CCLE	PVGTPFEE	DEG_SCF_FBW7_2	121:128	Mutation rewiring degron network	0.25
p.S131T	ACH-001061	Colon/Colorectal Cancer	CCLE	PVGTPFEE	DEG_SCF_FBW7_2	121:128	Mutation rewiring degron network	0.25
p.R133C	SIDM00217	Colorectal Carcinoma	GDSC	PVGTPFEE	DEG_SCF_FBW7_2	121:128	Mutation rewiring degron network	0.1944
p.R133C	ACH-000999	Colon/Colorectal Cancer	CCLE	PVGTPFEE	DEG_SCF_FBW7_2	121:128	Mutation rewiring degron network	0.1944
p.R133C	SNU-1040	large intestine	COSMIC	PVGTPFEE	DEG_SCF_FBW7_2	121:128	Mutation rewiring degron network	0.1944
p.G123D	SIDM01679	Small Cell Lung Carcinoma	GDSC	PVGTPFEE	DEG_SCF_FBW7_2	121:128	Mutation altering degron motif	0.6087
p.G123D	ACH-000523	Lung Cancer	CCLE	PVGTPFEE	DEG_SCF_FBW7_2	121:128	Mutation altering degron motif	0.6087
p.P180S	SIDM01451	Pancreatic Carcinoma	GDSC	AATST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.0833
p.P180S	ACH-000933	Pancreatic Cancer	CCLE	AATST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.0833
p.A164T	ACH-001510	Head and Neck Cancer	CCLE	AATST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.25
p.T157A	ACH-001610	Brain Cancer	CCLE	AATST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.0556
p.V180L	BFTC-905	urinary tract	COSMIC	AATST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.0833
p.V180L	TE-1	oesophagus	COSMIC	AATST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.0833

Kaplan plot for SDC3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SDC3

UniProt ID: O75056

Entrez ID: 9672

Protein name: Syndecan-3 (SYND3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SDC3 in