DegronMD

Uniprot ID: O75056

Source protein: Syndecan-3

Source gene: SDC3

Class: DEG_SCF_FBW7_2

Location: 121:128

E3 ligase: FBXW7

DEGRON score: 0.9197

ASA_SCORE: 90.1625

COIL: 0.9203

CONS_SCORE: 0.4742

DSS_SCORE: 0.6065

HELIX: 0.0225

FCONS_SCORE: 1.0347

RIG_SCORE: 0.7188

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S131C	TCGA-55-A48Y	LUAD	TCGA	PVGTPFEE	DEG_SCF_FBW7_2	0.25
p.R133H	TCGA-A5-A0GA	UCEC	TCGA	PVGTPFEE	DEG_SCF_FBW7_2	0.1944
p.G123C	TCGA-EE-A29X	SKCM	TCGA	PVGTPFEE	DEG_SCF_FBW7_2	0.6489
p.T129I	DO51926	BLCA	ICGC	PVGTPFEE	DEG_SCF_FBW7_2	0.3056
p.T120I	DO229005	COCA	ICGC	PVGTPFEE	DEG_SCF_FBW7_2	0.3056
p.A123V	DO233634	GACA	ICGC	PVGTPFEE	DEG_SCF_FBW7_2	0.6936
p.T135I	DO220885	MELA	ICGC	PVGTPFEE	DEG_SCF_FBW7_2	0.1389
p.P137L	DO220906	MELA	ICGC	PVGTPFEE	DEG_SCF_FBW7_2	0.0833
p.A128T	DO39288	THCA	ICGC	PVGTPFEE	DEG_SCF_FBW7_2	0.7139
p.T117M	SIDM00683	Prostate Carcinoma	GDSC	PVGTPFEE	DEG_SCF_FBW7_2	0.2222
p.S131T	SIDM00789	Colorectal Carcinoma	GDSC	PVGTPFEE	DEG_SCF_FBW7_2	0.25
p.S131T	ACH-000997	Colon/Colorectal Cancer	CCLE	PVGTPFEE	DEG_SCF_FBW7_2	0.25
p.S131T	ACH-001061	Colon/Colorectal Cancer	CCLE	PVGTPFEE	DEG_SCF_FBW7_2	0.25
p.R133C	SIDM00217	Colorectal Carcinoma	GDSC	PVGTPFEE	DEG_SCF_FBW7_2	0.1944
p.R133C	ACH-000999	Colon/Colorectal Cancer	CCLE	PVGTPFEE	DEG_SCF_FBW7_2	0.1944
p.R133C	SNU-1040	large_intestine	COSMIC	PVGTPFEE	DEG_SCF_FBW7_2	0.1944
p.G123D	SIDM01679	Small Cell Lung Carcinoma	GDSC	PVGTPFEE	DEG_SCF_FBW7_2	0.6087
p.G123D	ACH-000523	Lung Cancer	CCLE	PVGTPFEE	DEG_SCF_FBW7_2	0.6087

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75056	Syndecan-3	DEG_SCF_FBW7_2	121:128	PVGTPFEE	FBXW7	0.9197	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons