DegronMD

Uniprot ID: O75056

Source protein: Syndecan-3

Source gene: SDC3

Class: DEG_SPOP_SBC_1

Location: 167:171

E3 ligase: SPOP

DEGRON score: 0.9748

ASA_SCORE: 81.42

COIL: 0.9184

CONS_SCORE: 0.4021

DSS_SCORE: 0.5343

HELIX: 0.0286

FCONS_SCORE: 0.9057

RIG_SCORE: 0.6893

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P174L	DO222955	BTCA	ICGC	AATST	DEG_SPOP_SBC_1	0.25
p.P174L	DO228326	MALY	ICGC	AATST	DEG_SPOP_SBC_1	0.25
p.P174L	SIDM00121	T-Lymphoblastic Leukemia	GDSC	AATST	DEG_SPOP_SBC_1	0.25
p.P174L	ACH-001738	Leukemia	CCLE	AATST	DEG_SPOP_SBC_1	0.25
p.A171V	DO38887	STAD	ICGC	AATST	DEG_SPOP_SBC_1	0.6936
p.T178I	SIDM00582	Pancreatic Carcinoma	GDSC	AATST	DEG_SPOP_SBC_1	0.1389
p.T178I	SIDM00338	Acute Myeloid Leukemia	GDSC	AATST	DEG_SPOP_SBC_1	0.1389
p.T178I	SIDM00584	Osteosarcoma	GDSC	AATST	DEG_SPOP_SBC_1	0.1389
p.T178I	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	AATST	DEG_SPOP_SBC_1	0.1389
p.T178I	SIDM00239	Kidney Carcinoma	GDSC	AATST	DEG_SPOP_SBC_1	0.1389
p.T178I	SIDM00018	Acute Myeloid Leukemia	GDSC	AATST	DEG_SPOP_SBC_1	0.1389
p.P180S	SIDM01451	Pancreatic Carcinoma	GDSC	AATST	DEG_SPOP_SBC_1	0.0833
p.P180S	ACH-000933	Pancreatic Cancer	CCLE	AATST	DEG_SPOP_SBC_1	0.0833
p.A164T	ACH-001510	Head and Neck Cancer	CCLE	AATST	DEG_SPOP_SBC_1	0.25
p.T157A	ACH-001610	Brain Cancer	CCLE	AATST	DEG_SPOP_SBC_1	0.0556
p.V180L	BFTC-905	urinary_tract	COSMIC	AATST	DEG_SPOP_SBC_1	0.0833
p.V180L	TE-1	oesophagus	COSMIC	AATST	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75056	Syndecan-3	DEG_SPOP_SBC_1	167:171	AATST	SPOP	0.9748	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	594:598	AATST	SPOP	0.737	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1401:1405	AATST	SPOP	0.9715	More...
Q05209	Tyrosine-protein phosphatase non-receptor type 12	DEG_SPOP_SBC_1	633:637	AATST	SPOP	0.9815	More...
Q4KMQ1	Taperin	DEG_SPOP_SBC_1	289:293	AATST	SPOP	0.9965	More...
Q6W2J9	BCL-6 corepressor	DEG_SPOP_SBC_1	104:108	AATST	SPOP	0.9528	More...
Q86Z02	Homeodomain-interacting protein kinase 1	DEG_SPOP_SBC_1	95:99	AATST	SPOP	0.9812	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11752:11756	AATST	SPOP	0.9954	More...
Q96BD5	PHD finger protein 21A	DEG_SPOP_SBC_1	655:659	AATST	SPOP	0.9845	More...
Q96FS4	Signal-induced proliferation-associated protein 1	DEG_SPOP_SBC_1	82:86	AATST	SPOP	0.9975	More...
Q9BVL2	Nucleoporin p58/p45	DEG_SPOP_SBC_1	206:210	AATST	SPOP	0.9912	More...
Q9NZN1	Interleukin-1 receptor accessory protein-like 1	DEG_SPOP_SBC_1	594:598	AATST	SPOP	0.6429	More...
Q9ULV3	Cip1-interacting zinc finger protein	DEG_SPOP_SBC_1	581:585	AATST	SPOP	0.9621	More...
Q9Y446	Plakophilin-3	DEG_SPOP_SBC_1	205:209	AATST	SPOP	0.9186	More...
Q9Y6Y8	SEC23-interacting protein	DEG_SPOP_SBC_1	718:722	AATST	SPOP	0.6755	More...
Q8N3X1	Formin-binding protein 4	DEG_SPOP_SBC_1	181:185	AATST	SPOP	0.7939	More...
Q86XN7	Proline and serine-rich protein 1	DEG_SPOP_SBC_1	732:736	AATST	SPOP	0.9872	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons