DegronMD - Q4KMQ1(TPRN)

GO - Biological processes (BP): auditory receptor cell stereocilium organization [GO:0060088]; sensory perception of sound [GO:0007605]; stereocilium maintenance [GO:0120045]

GO - Molecular function (MF): phosphatase binding [GO:0019902]

GO - Cellular component (CC): stereocilium [GO:0032420]; stereocilium base [GO:0120044]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
PGTPSAT	DEG_SCF_FBW7_1	FBXW7	Taperin	265:271	More..
AATST	DEG_SPOP_SBC_1	SPOP	Taperin	289:293	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A264G	DO10582	COAD	ICGC	PGTPSAT	DEG_SCF_FBW7_1	265:271	Mutation blocking phosphorylation signal	0.75
p.S264R	DO229213	THCA	ICGC	PGTPSAT	DEG_SCF_FBW7_1	265:271	Mutation blocking phosphorylation signal	0.75
p.N268D	DO229253	THCA	ICGC	PGTPSAT	DEG_SCF_FBW7_1	265:271	Mutation altering degron motif	0.6932
p.G266R	DO229218	THCA	ICGC	PGTPSAT	DEG_SCF_FBW7_1	265:271	Mutation altering degron motif	0.6457
p.G266R	DO229213	THCA	ICGC	PGTPSAT	DEG_SCF_FBW7_1	265:271	Mutation altering degron motif	0.6457
p.G266R	ACH-000272	Kidney Cancer	CCLE	PGTPSAT	DEG_SCF_FBW7_1	265:271	Mutation altering degron motif	0.6457
p.G266R	ACH-001511	Head and Neck Cancer	CCLE	PGTPSAT	DEG_SCF_FBW7_1	265:271	Mutation altering degron motif	0.6457
p.S269Y	DO232761	PBCA	ICGC	PGTPSAT	DEG_SCF_FBW7_1	265:271	Mutation altering degron motif	0.6009
p.A278D	DO229028	LICA	ICGC	PGTPSAT	DEG_SCF_FBW7_1	265:271	Mutation blocking phosphorylation signal	0.5833
p.S288F	TCGA-VS-A950	CESC	TCGA	AATST	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.3056
p.S288F	DO51635	CESC	ICGC	AATST	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.3056
p.P262H	ACH-000390	Lung Cancer	CCLE	PGTPSAT	DEG_SCF_FBW7_1	265:271	Mutation rewiring degron network	0.25
p.Q285R	TCGA-AP-A1DK	UCEC	TCGA	AATST	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.2222
p.F297L	SIDM01126	Small Cell Lung Carcinoma	GDSC	AATST	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.2222
p.F297L	SIDM00654	Small Cell Lung Carcinoma	GDSC	AATST	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.2222
p.F297L	SIDM00690	Head and Neck Carcinoma	GDSC	AATST	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.2222
p.S276R	DO229041	LICA	ICGC	PGTPSAT	DEG_SCF_FBW7_1	265:271	Mutation rewiring degron network	0.1944
p.R284H	SIDM00981	B-Cell Non-Hodgkin's Lymphoma	GDSC	AATST	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.1944
p.H260P	ACH-000749	Lung Cancer	CCLE	PGTPSAT	DEG_SCF_FBW7_1	265:271	Mutation rewiring degron network	0.1944
p.L259P	DO229275	THCA	ICGC	PGTPSAT	DEG_SCF_FBW7_1	265:271	Mutation rewiring degron network	0.1667

Showing 1 to 20 of 26 entries

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No resistance data available for this Degron.

Kaplan plot for TPRN in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TPRN

UniProt ID: Q4KMQ1

Entrez ID: 286262

Protein name: Taperin

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for TPRN in