DegronMD - Q4KMQ1(TPRN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q285R	TCGA-AP-A1DK	UCEC	TCGA	AATST	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.2222
p.S288F	TCGA-VS-A950	CESC	TCGA	AATST	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.3056
p.S288F	DO51635	CESC	ICGC	AATST	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.3056
p.A264G	DO10582	COAD	ICGC	PGTPSAT	DEG_SCF_FBW7_1	265:271	Mutation blocking phosphorylation signal	0.75
p.A278D	DO229028	LICA	ICGC	PGTPSAT	DEG_SCF_FBW7_1	265:271	Mutation blocking phosphorylation signal	0.5833
p.P302T	DO229026	LICA	ICGC	AATST	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.0833
p.S276R	DO229041	LICA	ICGC	PGTPSAT	DEG_SCF_FBW7_1	265:271	Mutation rewiring degron network	0.1944
p.S269Y	DO232761	PBCA	ICGC	PGTPSAT	DEG_SCF_FBW7_1	265:271	Mutation altering degron motif	0.6009
p.N268D	DO229253	THCA	ICGC	PGTPSAT	DEG_SCF_FBW7_1	265:271	Mutation altering degron motif	0.6932
p.L259P	DO229275	THCA	ICGC	PGTPSAT	DEG_SCF_FBW7_1	265:271	Mutation rewiring degron network	0.1667
p.L259P	DO229234	THCA	ICGC	PGTPSAT	DEG_SCF_FBW7_1	265:271	Mutation rewiring degron network	0.1667
p.L259P	DO229250	THCA	ICGC	PGTPSAT	DEG_SCF_FBW7_1	265:271	Mutation rewiring degron network	0.1667
p.G266R	DO229218	THCA	ICGC	PGTPSAT	DEG_SCF_FBW7_1	265:271	Mutation altering degron motif	0.6457
p.G266R	DO229213	THCA	ICGC	PGTPSAT	DEG_SCF_FBW7_1	265:271	Mutation altering degron motif	0.6457
p.G266R	ACH-000272	Kidney Cancer	CCLE	PGTPSAT	DEG_SCF_FBW7_1	265:271	Mutation altering degron motif	0.6457
p.G266R	ACH-001511	Head and Neck Cancer	CCLE	PGTPSAT	DEG_SCF_FBW7_1	265:271	Mutation altering degron motif	0.6457
p.S264R	DO229213	THCA	ICGC	PGTPSAT	DEG_SCF_FBW7_1	265:271	Mutation blocking phosphorylation signal	0.75
p.F297L	SIDM01126	Small Cell Lung Carcinoma	GDSC	AATST	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.2222
p.F297L	SIDM00654	Small Cell Lung Carcinoma	GDSC	AATST	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.2222
p.F297L	SIDM00690	Head and Neck Carcinoma	GDSC	AATST	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.2222
p.R284H	SIDM00981	B-Cell Non-Hodgkin's Lymphoma	GDSC	AATST	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.1944
p.A302G	SIDM00832	Colorectal Carcinoma	GDSC	AATST	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.0833
p.I299T	SIDM00487	Colorectal Carcinoma	GDSC	AATST	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.1667
p.I299T	ACH-000963	Colon/Colorectal Cancer	CCLE	AATST	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.1667
p.P262H	ACH-000390	Lung Cancer	CCLE	PGTPSAT	DEG_SCF_FBW7_1	265:271	Mutation rewiring degron network	0.25
p.H260P	ACH-000749	Lung Cancer	CCLE	PGTPSAT	DEG_SCF_FBW7_1	265:271	Mutation rewiring degron network	0.1944

Kaplan plot for TPRN in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TPRN

UniProt ID: Q4KMQ1

Entrez ID: 286262

Protein name: Taperin

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TPRN in