DegronMD

Uniprot ID: Q4KMQ1

Source protein: Taperin

Source gene: TPRN

Class: DEG_SCF_FBW7_1

Location: 265:271

E3 ligase: FBXW7

DEGRON score: 0.9804

ASA_SCORE: 85.8286

COIL: 0.9704

CONS_SCORE: 0.3888

DSS_SCORE: 0.8158

HELIX: 0.0126

FCONS_SCORE: 0.9591

RIG_SCORE: 0.4639

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A264G	DO10582	COAD	ICGC	PGTPSAT	DEG_SCF_FBW7_1	0.75
p.A278D	DO229028	LICA	ICGC	PGTPSAT	DEG_SCF_FBW7_1	0.5833
p.S276R	DO229041	LICA	ICGC	PGTPSAT	DEG_SCF_FBW7_1	0.1944
p.S269Y	DO232761	PBCA	ICGC	PGTPSAT	DEG_SCF_FBW7_1	0.6009
p.N268D	DO229253	THCA	ICGC	PGTPSAT	DEG_SCF_FBW7_1	0.6932
p.L259P	DO229275	THCA	ICGC	PGTPSAT	DEG_SCF_FBW7_1	0.1667
p.L259P	DO229234	THCA	ICGC	PGTPSAT	DEG_SCF_FBW7_1	0.1667
p.L259P	DO229250	THCA	ICGC	PGTPSAT	DEG_SCF_FBW7_1	0.1667
p.G266R	DO229218	THCA	ICGC	PGTPSAT	DEG_SCF_FBW7_1	0.6457
p.G266R	DO229213	THCA	ICGC	PGTPSAT	DEG_SCF_FBW7_1	0.6457
p.G266R	ACH-000272	Kidney Cancer	CCLE	PGTPSAT	DEG_SCF_FBW7_1	0.6457
p.G266R	ACH-001511	Head and Neck Cancer	CCLE	PGTPSAT	DEG_SCF_FBW7_1	0.6457
p.S264R	DO229213	THCA	ICGC	PGTPSAT	DEG_SCF_FBW7_1	0.75
p.P262H	ACH-000390	Lung Cancer	CCLE	PGTPSAT	DEG_SCF_FBW7_1	0.25
p.H260P	ACH-000749	Lung Cancer	CCLE	PGTPSAT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4KMQ1	Taperin	DEG_SCF_FBW7_1	265:271	PGTPSAT	FBXW7	0.9804	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons