DegronMD - Q9NZN1(IL1RAPL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L584V	TCGA-12-0615	GBM	TCGA	AATST	DEG_SPOP_SBC_1	594:598	Mutation rewiring degron network	0.0556
p.L584V	DO11322	GBM	ICGC	AATST	DEG_SPOP_SBC_1	594:598	Mutation rewiring degron network	0.0556
p.A599S	TCGA-37-A5EL	LUSC	TCGA	AATST	DEG_SPOP_SBC_1	594:598	Mutation rewiring degron network	0.3056
p.A599S	DO223718	LUSC	ICGC	AATST	DEG_SPOP_SBC_1	594:598	Mutation rewiring degron network	0.3056
p.H604L	TCGA-56-8626	LUSC	TCGA	AATST	DEG_SPOP_SBC_1	594:598	Mutation rewiring degron network	0.1667
p.H604L	DO45506	LUSC	ICGC	AATST	DEG_SPOP_SBC_1	594:598	Mutation rewiring degron network	0.1667
p.Q585K	TCGA-77-8140	LUSC	TCGA	AATST	DEG_SPOP_SBC_1	594:598	Mutation rewiring degron network	0.0833
p.Q585K	DO26834	LUSC	ICGC	AATST	DEG_SPOP_SBC_1	594:598	Mutation rewiring degron network	0.0833
p.A601T	TCGA-AX-A1C4	UCEC	TCGA	AATST	DEG_SPOP_SBC_1	594:598	Mutation rewiring degron network	0.25
p.A601T	DO42480	UCEC	ICGC	AATST	DEG_SPOP_SBC_1	594:598	Mutation rewiring degron network	0.25
p.R608C	TCGA-B5-A3FC	UCEC	TCGA	AATST	DEG_SPOP_SBC_1	594:598	Mutation rewiring degron network	0.0556
p.R608C	DO41871	UCEC	ICGC	AATST	DEG_SPOP_SBC_1	594:598	Mutation rewiring degron network	0.0556
p.S591Y	DO224847	BRCA	ICGC	AATST	DEG_SPOP_SBC_1	594:598	Mutation rewiring degron network	0.25
p.S591Y	DO227473	BRCA	ICGC	AATST	DEG_SPOP_SBC_1	594:598	Mutation rewiring degron network	0.25
p.R608H	DO227996	COCA	ICGC	AATST	DEG_SPOP_SBC_1	594:598	Mutation rewiring degron network	0.0556
p.R608H	DO50341	ESAD	ICGC	AATST	DEG_SPOP_SBC_1	594:598	Mutation rewiring degron network	0.0556
p.A589D	DO222804	COCA	ICGC	AATST	DEG_SPOP_SBC_1	594:598	Mutation rewiring degron network	0.1944
p.T598K	DO233726	GACA	ICGC	AATST	DEG_SPOP_SBC_1	594:598	Mutation altering degron motif	0.7306
p.R608L	DO230965	LUSC	ICGC	AATST	DEG_SPOP_SBC_1	594:598	Mutation rewiring degron network	0.0556
p.A595S	DO229470	SKCA	ICGC	AATST	DEG_SPOP_SBC_1	594:598	Mutation altering degron motif	0.6477
p.R608S	DO68928	THCA	ICGC	AATST	DEG_SPOP_SBC_1	594:598	Mutation rewiring degron network	0.0556
p.I590T	SIDM00487	Colorectal Carcinoma	GDSC	AATST	DEG_SPOP_SBC_1	594:598	Mutation rewiring degron network	0.2222
p.I590T	ACH-000963	Colon/Colorectal Cancer	CCLE	AATST	DEG_SPOP_SBC_1	594:598	Mutation rewiring degron network	0.2222
p.I590T	CCK-81	large intestine	COSMIC	AATST	DEG_SPOP_SBC_1	594:598	Mutation rewiring degron network	0.2222
p.A594T	SIDM00220	Ovarian Carcinoma	GDSC	AATST	DEG_SPOP_SBC_1	594:598	Mutation altering degron motif	0.7139
p.A594T	ACH-000962	Ovarian Cancer	CCLE	AATST	DEG_SPOP_SBC_1	594:598	Mutation altering degron motif	0.7139
p.A594T	ACH-001145	Ovarian Cancer	CCLE	AATST	DEG_SPOP_SBC_1	594:598	Mutation altering degron motif	0.7139

Kaplan plot for IL1RAPL1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IL1RAPL1

UniProt ID: Q9NZN1

Entrez ID: 11141

Protein name: Interleukin-1 receptor accessory protein-like 1 (IL-1-RAPL-1) (IL-1RAPL-1) (IL1RAPL-1) (EC 3.2.2.6) (Oligophrenin-4) (Three immunoglobulin domain-containing IL-1 receptor-related 2) (TIGIRR-2) (X-linked interleukin-1 receptor accessory protein-like 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IL1RAPL1 in