DegronMD

Uniprot ID: Q9NZN1

Source protein: Interleukin-1 receptor accessory protein-like 1

Source gene: IL1RAPL1

Class: DEG_SPOP_SBC_1

Location: 594:598

E3 ligase: SPOP

DEGRON score: 0.6429

ASA_SCORE: 70.44

COIL: 0.7512

CONS_SCORE: 0.7898

DSS_SCORE: 0.3163

HELIX: 0.2048

FCONS_SCORE: 1.0249

RIG_SCORE: 0.7351

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L584V	TCGA-12-0615	GBM	TCGA	AATST	DEG_SPOP_SBC_1	0.0556
p.L584V	DO11322	GBM	ICGC	AATST	DEG_SPOP_SBC_1	0.0556
p.A599S	TCGA-37-A5EL	LUSC	TCGA	AATST	DEG_SPOP_SBC_1	0.3056
p.A599S	DO223718	LUSC	ICGC	AATST	DEG_SPOP_SBC_1	0.3056
p.H604L	TCGA-56-8626	LUSC	TCGA	AATST	DEG_SPOP_SBC_1	0.1667
p.H604L	DO45506	LUSC	ICGC	AATST	DEG_SPOP_SBC_1	0.1667
p.Q585K	TCGA-77-8140	LUSC	TCGA	AATST	DEG_SPOP_SBC_1	0.0833
p.Q585K	DO26834	LUSC	ICGC	AATST	DEG_SPOP_SBC_1	0.0833
p.A601T	TCGA-AX-A1C4	UCEC	TCGA	AATST	DEG_SPOP_SBC_1	0.25
p.A601T	DO42480	UCEC	ICGC	AATST	DEG_SPOP_SBC_1	0.25
p.R608C	TCGA-B5-A3FC	UCEC	TCGA	AATST	DEG_SPOP_SBC_1	0.0556
p.R608C	DO41871	UCEC	ICGC	AATST	DEG_SPOP_SBC_1	0.0556
p.S591Y	DO224847	BRCA	ICGC	AATST	DEG_SPOP_SBC_1	0.25
p.S591Y	DO227473	BRCA	ICGC	AATST	DEG_SPOP_SBC_1	0.25
p.R608H	DO227996	COCA	ICGC	AATST	DEG_SPOP_SBC_1	0.0556
p.R608H	DO50341	ESAD	ICGC	AATST	DEG_SPOP_SBC_1	0.0556
p.A589D	DO222804	COCA	ICGC	AATST	DEG_SPOP_SBC_1	0.1944
p.T598K	DO233726	GACA	ICGC	AATST	DEG_SPOP_SBC_1	0.7306
p.R608L	DO230965	LUSC	ICGC	AATST	DEG_SPOP_SBC_1	0.0556
p.A595S	DO229470	SKCA	ICGC	AATST	DEG_SPOP_SBC_1	0.6477
p.R608S	DO68928	THCA	ICGC	AATST	DEG_SPOP_SBC_1	0.0556
p.I590T	SIDM00487	Colorectal Carcinoma	GDSC	AATST	DEG_SPOP_SBC_1	0.2222
p.I590T	ACH-000963	Colon/Colorectal Cancer	CCLE	AATST	DEG_SPOP_SBC_1	0.2222
p.I590T	CCK-81	large_intestine	COSMIC	AATST	DEG_SPOP_SBC_1	0.2222
p.A594T	SIDM00220	Ovarian Carcinoma	GDSC	AATST	DEG_SPOP_SBC_1	0.7139
p.A594T	ACH-000962	Ovarian Cancer	CCLE	AATST	DEG_SPOP_SBC_1	0.7139
p.A594T	ACH-001145	Ovarian Cancer	CCLE	AATST	DEG_SPOP_SBC_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75056	Syndecan-3	DEG_SPOP_SBC_1	167:171	AATST	SPOP	0.9748	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	594:598	AATST	SPOP	0.737	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1401:1405	AATST	SPOP	0.9715	More...
Q05209	Tyrosine-protein phosphatase non-receptor type 12	DEG_SPOP_SBC_1	633:637	AATST	SPOP	0.9815	More...
Q4KMQ1	Taperin	DEG_SPOP_SBC_1	289:293	AATST	SPOP	0.9965	More...
Q6W2J9	BCL-6 corepressor	DEG_SPOP_SBC_1	104:108	AATST	SPOP	0.9528	More...
Q86Z02	Homeodomain-interacting protein kinase 1	DEG_SPOP_SBC_1	95:99	AATST	SPOP	0.9812	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11752:11756	AATST	SPOP	0.9954	More...
Q96BD5	PHD finger protein 21A	DEG_SPOP_SBC_1	655:659	AATST	SPOP	0.9845	More...
Q96FS4	Signal-induced proliferation-associated protein 1	DEG_SPOP_SBC_1	82:86	AATST	SPOP	0.9975	More...
Q9BVL2	Nucleoporin p58/p45	DEG_SPOP_SBC_1	206:210	AATST	SPOP	0.9912	More...
Q9NZN1	Interleukin-1 receptor accessory protein-like 1	DEG_SPOP_SBC_1	594:598	AATST	SPOP	0.6429	More...
Q9ULV3	Cip1-interacting zinc finger protein	DEG_SPOP_SBC_1	581:585	AATST	SPOP	0.9621	More...
Q9Y446	Plakophilin-3	DEG_SPOP_SBC_1	205:209	AATST	SPOP	0.9186	More...
Q9Y6Y8	SEC23-interacting protein	DEG_SPOP_SBC_1	718:722	AATST	SPOP	0.6755	More...
Q8N3X1	Formin-binding protein 4	DEG_SPOP_SBC_1	181:185	AATST	SPOP	0.7939	More...
Q86XN7	Proline and serine-rich protein 1	DEG_SPOP_SBC_1	732:736	AATST	SPOP	0.9872	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons