DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 11752:11756

E3 ligase: SPOP

DEGRON score: 0.9954

ASA_SCORE: 81.48

COIL: 0.8358

CONS_SCORE: 0

DSS_SCORE: 0.587

HELIX: 0.017

FCONS_SCORE: 0

RIG_SCORE: 0.6337

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V11743M	TCGA-05-4398	LUAD	TCGA	AATST	DEG_SPOP_SBC_1	0.0833
p.V11743M	TCGA-06-0875	GBM	TCGA	AATST	DEG_SPOP_SBC_1	0.0833
p.V11743M	DO11830	GBM	ICGC	AATST	DEG_SPOP_SBC_1	0.0833
p.V11743M	DO25847	LUAD	ICGC	AATST	DEG_SPOP_SBC_1	0.0833
p.A11752T	TCGA-06-5416	GBM	TCGA	AATST	DEG_SPOP_SBC_1	0.7139
p.A11752T	DO10880	GBM	ICGC	AATST	DEG_SPOP_SBC_1	0.7139
p.S11764F	TCGA-AG-A002	READ	TCGA	AATST	DEG_SPOP_SBC_1	0.5556
p.P11765S	TCGA-D3-A51G	SKCM	TCGA	AATST	DEG_SPOP_SBC_1	0.0833
p.P11765S	TCGA-D3-A8GC	SKCM	TCGA	AATST	DEG_SPOP_SBC_1	0.0833
p.P11765S	DO50281	SKCM	ICGC	AATST	DEG_SPOP_SBC_1	0.0833
p.P11765S	DO47700	SKCM	ICGC	AATST	DEG_SPOP_SBC_1	0.0833
p.T11744N	DO224668	COCA	ICGC	AATST	DEG_SPOP_SBC_1	0.1111
p.T11744P	DO232761	PBCA	ICGC	AATST	DEG_SPOP_SBC_1	0.1111
p.V11743E	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	AATST	DEG_SPOP_SBC_1	0.0833
p.S11745L	SIDM00146	Breast Carcinoma	GDSC	AATST	DEG_SPOP_SBC_1	0.5833
p.S11745L	ACH-000768	Breast Cancer	CCLE	AATST	DEG_SPOP_SBC_1	0.5833
p.S11745L	MDA-MB-231	breast	COSMIC	AATST	DEG_SPOP_SBC_1	0.5833
p.Q11746E	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	AATST	DEG_SPOP_SBC_1	0.1667
p.Q11746E	KYSE-450	oesophagus	COSMIC	AATST	DEG_SPOP_SBC_1	0.1667
p.S11755N	SIDM01128	Small Cell Lung Carcinoma	GDSC	AATST	DEG_SPOP_SBC_1	0.7069
p.S11755N	ACH-000767	Lung Cancer	CCLE	AATST	DEG_SPOP_SBC_1	0.7069
p.S11755N	NCI-H526	lung	COSMIC	AATST	DEG_SPOP_SBC_1	0.7069
p.M11742I	SIDM01228	Melanoma	GDSC	AATST	DEG_SPOP_SBC_1	0.0556
p.M11742I	ACH-000931	Skin Cancer	CCLE	AATST	DEG_SPOP_SBC_1	0.0556
p.M11742I	ACH-001024	Skin Cancer	CCLE	AATST	DEG_SPOP_SBC_1	0.0556
p.M11742I	CHL-1	skin	COSMIC	AATST	DEG_SPOP_SBC_1	0.0556
p.A11753E	ACH-001030	Bone Cancer	CCLE	AATST	DEG_SPOP_SBC_1	0.659
p.S11749R	ACH-001030	Bone Cancer	CCLE	AATST	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75056	Syndecan-3	DEG_SPOP_SBC_1	167:171	AATST	SPOP	0.9748	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	594:598	AATST	SPOP	0.737	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1401:1405	AATST	SPOP	0.9715	More...
Q05209	Tyrosine-protein phosphatase non-receptor type 12	DEG_SPOP_SBC_1	633:637	AATST	SPOP	0.9815	More...
Q4KMQ1	Taperin	DEG_SPOP_SBC_1	289:293	AATST	SPOP	0.9965	More...
Q6W2J9	BCL-6 corepressor	DEG_SPOP_SBC_1	104:108	AATST	SPOP	0.9528	More...
Q86Z02	Homeodomain-interacting protein kinase 1	DEG_SPOP_SBC_1	95:99	AATST	SPOP	0.9812	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11752:11756	AATST	SPOP	0.9954	More...
Q96BD5	PHD finger protein 21A	DEG_SPOP_SBC_1	655:659	AATST	SPOP	0.9845	More...
Q96FS4	Signal-induced proliferation-associated protein 1	DEG_SPOP_SBC_1	82:86	AATST	SPOP	0.9975	More...
Q9BVL2	Nucleoporin p58/p45	DEG_SPOP_SBC_1	206:210	AATST	SPOP	0.9912	More...
Q9NZN1	Interleukin-1 receptor accessory protein-like 1	DEG_SPOP_SBC_1	594:598	AATST	SPOP	0.6429	More...
Q9ULV3	Cip1-interacting zinc finger protein	DEG_SPOP_SBC_1	581:585	AATST	SPOP	0.9621	More...
Q9Y446	Plakophilin-3	DEG_SPOP_SBC_1	205:209	AATST	SPOP	0.9186	More...
Q9Y6Y8	SEC23-interacting protein	DEG_SPOP_SBC_1	718:722	AATST	SPOP	0.6755	More...
Q8N3X1	Formin-binding protein 4	DEG_SPOP_SBC_1	181:185	AATST	SPOP	0.7939	More...
Q86XN7	Proline and serine-rich protein 1	DEG_SPOP_SBC_1	732:736	AATST	SPOP	0.9872	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AATST

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of AATST