DegronMD - Q6W2J9(BCOR)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G95V	TCGA-05-4427	LUAD	TCGA	AATST	DEG_SPOP_SBC_1	104:108	Mutation rewiring degron network	0.0833
p.G95V	DO23666	LUAD	ICGC	AATST	DEG_SPOP_SBC_1	104:108	Mutation rewiring degron network	0.0833
p.S907N	TCGA-12-0818	GBM	TCGA	PVSTPFLE	DEG_SCF_FBW7_2	895:902	Mutation rewiring degron network	0.1944
p.S907N	DO12892	GBM	ICGC	PVSTPFLE	DEG_SCF_FBW7_2	895:902	Mutation rewiring degron network	0.1944
p.V912L	TCGA-49-AARO	LUAD	TCGA	PVSTPFLE	DEG_SCF_FBW7_2	895:902	Mutation rewiring degron network	0.0556
p.V912L	DO218924	LUAD	ICGC	PVSTPFLE	DEG_SCF_FBW7_2	895:902	Mutation rewiring degron network	0.0556
p.E117V	TCGA-55-6985	LUAD	TCGA	AATST	DEG_SPOP_SBC_1	104:108	Mutation rewiring degron network	0.0833
p.E117V	DO25659	LUAD	ICGC	AATST	DEG_SPOP_SBC_1	104:108	Mutation rewiring degron network	0.0833
p.R243C	TCGA-A5-A0G2	UCEC	TCGA	PPHY	ITCH	249:252	Mutation rewiring degron network	0.1667
p.R243C	DO41235	UCEC	ICGC	PPHY	ITCH	249:252	Mutation rewiring degron network	0.1667
p.S116L	TCGA-AN-A046	BRCA	TCGA	AATST	DEG_SPOP_SBC_1	104:108	Mutation blocking phosphorylation signal	0.5556
p.S116L	TCGA-AP-A056	UCEC	TCGA	AATST	DEG_SPOP_SBC_1	104:108	Mutation blocking phosphorylation signal	0.5556
p.S116L	DO1285	BRCA	ICGC	AATST	DEG_SPOP_SBC_1	104:108	Mutation blocking phosphorylation signal	0.5556
p.S116L	DO43971	UCEC	ICGC	AATST	DEG_SPOP_SBC_1	104:108	Mutation blocking phosphorylation signal	0.5556
p.R1447H	TCGA-AX-A06H	UCEC	TCGA	PCSSS	DEG_SPOP_SBC_1	1435:1439	Mutation rewiring degron network	0.1111
p.S1315Y	TCGA-B5-A3FA	UCEC	TCGA	IKENQ	DEG_APCC_KENBOX_2	1324:1328	Mutation rewiring degron network	0.0833
p.S1315Y	DO52402	UCEC	ICGC	IKENQ	DEG_APCC_KENBOX_2	1324:1328	Mutation rewiring degron network	0.0833
p.K889N	TCGA-BF-AAOU	SKCM	TCGA	NKENL	DEG_APCC_KENBOX_2	888:892	Mutation altering degron motif	0.6918
p.K889N	DO219460	SKCM	ICGC	NKENL	DEG_APCC_KENBOX_2	888:892	Mutation altering degron motif	0.6918
p.A283T	TCGA-BS-A0TC	UCEC	TCGA	LSTPSAS	DEG_SCF_FBW7_1	267:273	Mutation rewiring degron network	0.0556
p.A283T	DO42400	UCEC	ICGC	LSTPSAS	DEG_SCF_FBW7_1	267:273	Mutation rewiring degron network	0.0556
p.K1329R	TCGA-D1-A103	UCEC	TCGA	IKENQ	DEG_APCC_KENBOX_2	1324:1328	Mutation blocking ubiquitination signal	0.75
p.K1329R	DO42312	UCEC	ICGC	IKENQ	DEG_APCC_KENBOX_2	1324:1328	Mutation blocking ubiquitination signal	0.75
p.S897L	TCGA-DK-A6AW	BLCA	TCGA	PVSTPFLE	DEG_SCF_FBW7_2	895:902	Mutation altering degron motif	0.6556
p.S897L	DO48566	BLCA	ICGC	PVSTPFLE	DEG_SCF_FBW7_2	895:902	Mutation altering degron motif	0.6556
p.V253I	TCGA-DU-6403	LGG	TCGA	PPHY	ITCH	249:252	Mutation rewiring degron network	0.3056
p.V253I	DO22586	LGG	ICGC	PPHY	ITCH	249:252	Mutation rewiring degron network	0.3056
p.R243H	TCGA-F4-6805	COAD	TCGA	PPHY	ITCH	249:252	Mutation rewiring degron network	0.1667
p.R243H	DO8554	COAD	ICGC	PPHY	ITCH	249:252	Mutation rewiring degron network	0.1667
p.R102L	TCGA-FS-A1ZN	SKCM	TCGA	AATST	DEG_SPOP_SBC_1	104:108	Mutation rewiring degron network	0.2778
p.R102L	DO38165	SKCM	ICGC	AATST	DEG_SPOP_SBC_1	104:108	Mutation rewiring degron network	0.2778
p.P248Q	TCGA-GN-A267	SKCM	TCGA	PPHY	ITCH	249:252	Mutation rewiring degron network	0.3056
p.P248Q	DO38147	SKCM	ICGC	PPHY	ITCH	249:252	Mutation rewiring degron network	0.3056
p.S928I	TCGA-L9-A7SV	LUAD	TCGA	VDVTPTYT	DEG_SCF_FBW7_1	933:940	Mutation blocking phosphorylation signal	0.6389
p.S928I	DO49875	LUAD	ICGC	VDVTPTYT	DEG_SCF_FBW7_1	933:940	Mutation blocking phosphorylation signal	0.6389
p.D908H	TCGA-OR-A5K6	ACC	TCGA	PVSTPFLE	DEG_SCF_FBW7_2	895:902	Mutation rewiring degron network	0.1667
p.S271L	TCGA-SY-A9G5	BLCA	TCGA	LSTPSAS	DEG_SCF_FBW7_1	267:273	Mutation altering degron motif	0.6556
p.S271L	DO51906	BLCA	ICGC	LSTPSAS	DEG_SCF_FBW7_1	267:273	Mutation altering degron motif	0.6556
p.E1337K	TCGA-YY-A8LH	PAAD	TCGA	IKENQ	DEG_APCC_KENBOX_2	1324:1328	Mutation rewiring degron network	0.0833
p.D908N	TCGA-Z2-A8RT	SKCM	TCGA	PVSTPFLE	DEG_SCF_FBW7_2	895:902	Mutation rewiring degron network	0.1667
p.D908N	DO51301	SKCM	ICGC	PVSTPFLE	DEG_SCF_FBW7_2	895:902	Mutation rewiring degron network	0.1667
p.N1425S	DO223879	AML	ICGC	PCSSS	DEG_SPOP_SBC_1	1435:1439	Mutation rewiring degron network	0.0556
p.N1425S	DO234452	BPLL	ICGC	PCSSS	DEG_SPOP_SBC_1	1435:1439	Mutation rewiring degron network	0.0556
p.N1425S	DO233964	BPLL	ICGC	PCSSS	DEG_SPOP_SBC_1	1435:1439	Mutation rewiring degron network	0.0556
p.N1425S	DO51604	CESC	ICGC	PCSSS	DEG_SPOP_SBC_1	1435:1439	Mutation rewiring degron network	0.0556
p.N1425S	DO219888	DLBC	ICGC	PCSSS	DEG_SPOP_SBC_1	1435:1439	Mutation rewiring degron network	0.0556
p.N1425S	DO218941	LUAD	ICGC	PCSSS	DEG_SPOP_SBC_1	1435:1439	Mutation rewiring degron network	0.0556
p.N1425S	DO25068	LUAD	ICGC	PCSSS	DEG_SPOP_SBC_1	1435:1439	Mutation rewiring degron network	0.0556
p.N1425S	DO23976	LUAD	ICGC	PCSSS	DEG_SPOP_SBC_1	1435:1439	Mutation rewiring degron network	0.0556
p.N1425S	DO52658	MALY	ICGC	PCSSS	DEG_SPOP_SBC_1	1435:1439	Mutation rewiring degron network	0.0556
p.N1425S	DO33680	PACA	ICGC	PCSSS	DEG_SPOP_SBC_1	1435:1439	Mutation rewiring degron network	0.0556
p.N1425S	DO219775	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	1435:1439	Mutation rewiring degron network	0.0556
p.N1425S	DO219774	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	1435:1439	Mutation rewiring degron network	0.0556
p.N1425S	DO219768	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	1435:1439	Mutation rewiring degron network	0.0556
p.N1425S	DO219765	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	1435:1439	Mutation rewiring degron network	0.0556
p.N1425S	DO48172	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	1435:1439	Mutation rewiring degron network	0.0556
p.N1425S	DO40843	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	1435:1439	Mutation rewiring degron network	0.0556
p.N1425S	DO50081	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	1435:1439	Mutation rewiring degron network	0.0556
p.N1425S	DO40924	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	1435:1439	Mutation rewiring degron network	0.0556
p.N1425S	DO42177	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	1435:1439	Mutation rewiring degron network	0.0556
p.N1425S	DO42023	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	1435:1439	Mutation rewiring degron network	0.0556
p.N1425S	DO41002	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	1435:1439	Mutation rewiring degron network	0.0556
p.N1425S	DO42304	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	1435:1439	Mutation rewiring degron network	0.0556
p.N1425S	DO43001	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	1435:1439	Mutation rewiring degron network	0.0556
p.N1425S	DO43170	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	1435:1439	Mutation rewiring degron network	0.0556
p.N1425S	DO52419	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	1435:1439	Mutation rewiring degron network	0.0556
p.N1425S	DO41704	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	1435:1439	Mutation rewiring degron network	0.0556
p.N1425S	DO41686	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	1435:1439	Mutation rewiring degron network	0.0556
p.N1425S	DO41590	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	1435:1439	Mutation rewiring degron network	0.0556
p.N1425S	DO41879	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	1435:1439	Mutation rewiring degron network	0.0556
p.N1425S	DO41823	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	1435:1439	Mutation rewiring degron network	0.0556
p.N1425S	DO43915	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	1435:1439	Mutation rewiring degron network	0.0556
p.N1425S	DO41205	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	1435:1439	Mutation rewiring degron network	0.0556
p.N1425S	DO42592	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	1435:1439	Mutation rewiring degron network	0.0556
p.N1425S	DO42432	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	1435:1439	Mutation rewiring degron network	0.0556
p.N1425S	DO42841	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	1435:1439	Mutation rewiring degron network	0.0556
p.N1425S	DO41446	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	1435:1439	Mutation rewiring degron network	0.0556
p.N1425S	DO42721	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	1435:1439	Mutation rewiring degron network	0.0556
p.N1425S	DO42681	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	1435:1439	Mutation rewiring degron network	0.0556
p.N1425S	DO229086	UTCA	ICGC	PCSSS	DEG_SPOP_SBC_1	1435:1439	Mutation rewiring degron network	0.0556
p.F924C	DO234458	BPLL	ICGC	VDVTPTYT	DEG_SCF_FBW7_1	933:940	Mutation rewiring degron network	0.0833
p.L279F	DO1076	BRCA	ICGC	LSTPSAS	DEG_SCF_FBW7_1	267:273	Mutation rewiring degron network	0.1667
p.R102W	DO233156	GACA	ICGC	AATST	DEG_SPOP_SBC_1	104:108	Mutation rewiring degron network	0.2778
p.L1425M	DO229022	LICA	ICGC	PCSSS	DEG_SPOP_SBC_1	1435:1439	Mutation rewiring degron network	0.0556
p.L884M	DO229045	LICA	ICGC	NKENL	DEG_APCC_KENBOX_2	888:892	Mutation rewiring degron network	0.2222
p.Y1316F	DO44886	LIHC	ICGC	IKENQ	DEG_APCC_KENBOX_2	1324:1328	Mutation rewiring degron network	0.1111
p.R266M	DO27318	LUSC	ICGC	LSTPSAS	DEG_SCF_FBW7_1	267:273	Mutation rewiring degron network	0.3056
p.R243L	DO228349	MALY	ICGC	PPHY	ITCH	249:252	Mutation rewiring degron network	0.1667
p.R243L	SIDM00656	Burkitt's Lymphoma	GDSC	PPHY	ITCH	249:252	Mutation rewiring degron network	0.1667
p.R243L	SIDM00641	Burkitt's Lymphoma	GDSC	PPHY	ITCH	249:252	Mutation rewiring degron network	0.1667
p.R243L	ACH-000944	Lymphoma	CCLE	PPHY	ITCH	249:252	Mutation rewiring degron network	0.1667
p.R243L	NAMALWA	haematopoietic and lymphoid tissue	COSMIC	PPHY	ITCH	249:252	Mutation rewiring degron network	0.1667
p.P264S	DO27931	ORCA	ICGC	LSTPSAS	DEG_SCF_FBW7_1	267:273	Mutation rewiring degron network	0.25
p.S1320G	DO42033	UCEC	ICGC	IKENQ	DEG_APCC_KENBOX_2	1324:1328	Mutation substituting flanking lysine	0.3333
p.L279H	SIDM02024	Esophageal Carcinoma	GDSC	LSTPSAS	DEG_SCF_FBW7_1	267:273	Mutation rewiring degron network	0.1667
p.L279V	SIDM02024	Esophageal Carcinoma	GDSC	LSTPSAS	DEG_SCF_FBW7_1	267:273	Mutation rewiring degron network	0.1667
p.V878A	SIDM00321	Ovarian Carcinoma	GDSC	NKENL	DEG_APCC_KENBOX_2	888:892	Mutation rewiring degron network	0.0556
p.V878A	SIDM01004	Chronic Myelogenous Leukemia	GDSC	NKENL	DEG_APCC_KENBOX_2	888:892	Mutation rewiring degron network	0.0556
p.V878A	SIDM00167	Head and Neck Carcinoma	GDSC	NKENL	DEG_APCC_KENBOX_2	888:892	Mutation rewiring degron network	0.0556
p.V878A	TYK-nu	ovary	COSMIC	NKENL	DEG_APCC_KENBOX_2	888:892	Mutation rewiring degron network	0.0556
p.V878A	KCL-22	haematopoietic and lymphoid tissue	COSMIC	NKENL	DEG_APCC_KENBOX_2	888:892	Mutation rewiring degron network	0.0556
p.P255R	SIDM01141	Ovarian Carcinoma	GDSC	PPHY	ITCH	249:252	Mutation rewiring degron network	0.25
p.P255R	ACH-000291	Ovarian Cancer	CCLE	PPHY	ITCH	249:252	Mutation rewiring degron network	0.25
p.P255R	OV-90	ovary	COSMIC	PPHY	ITCH	249:252	Mutation rewiring degron network	0.25
p.R1316M	SIDM00007	Other Solid Cancers	GDSC	IKENQ	DEG_APCC_KENBOX_2	1324:1328	Mutation rewiring degron network	0.1111
p.G254D	SIDM00007	Other Solid Cancers	GDSC	PPHY	ITCH	249:252	Mutation rewiring degron network	0.2778
p.G254D	ACH-001550	Skin Cancer	CCLE	PPHY	ITCH	249:252	Mutation rewiring degron network	0.2778
p.G254D	MCC13	skin	COSMIC	PPHY	ITCH	249:252	Mutation rewiring degron network	0.2778
p.G254S	SIDM00007	Other Solid Cancers	GDSC	PPHY	ITCH	249:252	Mutation rewiring degron network	0.2778
p.G254S	ACH-001550	Skin Cancer	CCLE	PPHY	ITCH	249:252	Mutation rewiring degron network	0.2778
p.G254S	MCC13	skin	COSMIC	PPHY	ITCH	249:252	Mutation rewiring degron network	0.2778
p.H256Q	SIDM00507	Other Solid Cancers	GDSC	PPHY	ITCH	249:252	Mutation rewiring degron network	0.2222
p.H256Q	ACH-001490	Lung Cancer	CCLE	PPHY	ITCH	249:252	Mutation rewiring degron network	0.2222
p.H256Q	COR-L321	NS	COSMIC	PPHY	ITCH	249:252	Mutation rewiring degron network	0.2222
p.T936N	SIDM00934	Pancreatic Carcinoma	GDSC	VDVTPTYT	DEG_SCF_FBW7_1	933:940	Mutation altering degron motif	0.8166
p.T936N	CAPAN-1	pancreas	COSMIC	VDVTPTYT	DEG_SCF_FBW7_1	933:940	Mutation altering degron motif	0.8166
p.K1325R	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	IKENQ	DEG_APCC_KENBOX_2	1324:1328	Mutation altering degron motif	0.7237
p.E946K	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	VDVTPTYT	DEG_SCF_FBW7_1	933:940	Mutation rewiring degron network	0.1667
p.E946K	ACH-002253	Lymphoma	CCLE	VDVTPTYT	DEG_SCF_FBW7_1	933:940	Mutation rewiring degron network	0.1667
p.E946K	JSC-1	haematopoietic and lymphoid tissue	COSMIC	VDVTPTYT	DEG_SCF_FBW7_1	933:940	Mutation rewiring degron network	0.1667
p.C94Y	SIDM00783	Colorectal Carcinoma	GDSC	AATST	DEG_SPOP_SBC_1	104:108	Mutation rewiring degron network	0.0556
p.C94Y	ACH-000971	Colon/Colorectal Cancer	CCLE	AATST	DEG_SPOP_SBC_1	104:108	Mutation rewiring degron network	0.0556
p.C94Y	HCT-116	large intestine	COSMIC	AATST	DEG_SPOP_SBC_1	104:108	Mutation rewiring degron network	0.0556
p.G111R	SIDM01446	Glioblastoma	GDSC	AATST	DEG_SPOP_SBC_1	104:108	Mutation rewiring degron network	0.25
p.G111R	ACH-000543	Brain Cancer	CCLE	AATST	DEG_SPOP_SBC_1	104:108	Mutation rewiring degron network	0.25
p.Y246S	ACH-000008	Skin Cancer	CCLE	PPHY	ITCH	249:252	Mutation rewiring degron network	0.25
p.Y246S	ACH-000248	Breast Cancer	CCLE	PPHY	ITCH	249:252	Mutation rewiring degron network	0.25
p.A242V	IGROV-1	ovary	COSMIC	PPHY	ITCH	249:252	Mutation rewiring degron network	0.1389
p.T275A	SW756	cervix	COSMIC	LSTPSAS	DEG_SCF_FBW7_1	267:273	Mutation rewiring degron network	0.2778
p.P100L	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	AATST	DEG_SPOP_SBC_1	104:108	Mutation blocking ubiquitination signal	0.6667
p.R268C	SNU-407	large intestine	COSMIC	LSTPSAS	DEG_SCF_FBW7_1	267:273	Mutation altering degron motif	0.8301
p.R257H	NCI-H1048	lung	COSMIC	LSTPSAS	DEG_SCF_FBW7_1	267:273	Mutation rewiring degron network	0.0556
p.R257H	NCI-H1048	lung	COSMIC	PPHY	ITCH	249:252	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BCOR

UniProt ID: Q6W2J9

Entrez ID: 54880

Protein name: BCL-6 corepressor (BCoR)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for BCOR in