DegronMD - Q6W2J9(BCOR)

FUNCTION: Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepr... View more >>

GO - Biological processes (BP): blastocyst hatching [GO:0001835]; chromatin organization [GO:0006325]; heart development [GO:0007507]; histone H2A monoubiquitination [GO:0035518]; negative regulation of bone mineralization [GO:0030502]; negative regulation of histone H3-K36 methylation [GO:0000415]; negative regulation of histone ... View more >>

GO - Molecular function (MF): DNA-binding transcription factor binding [GO:0140297]; heat shock protein binding [GO:0031072]; histone deacetylase binding [GO:0042826]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]; transcript... View more >>

GO - Cellular component (CC): BCOR complex [GO:0140261]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R268C	SNU-407	large intestine	COSMIC	LSTPSAS	DEG_SCF_FBW7_1	267:273	Mutation altering degron motif	0.8301
p.T936N	SIDM00934	Pancreatic Carcinoma	GDSC	VDVTPTYT	DEG_SCF_FBW7_1	933:940	Mutation altering degron motif	0.8166
p.T936N	CAPAN-1	pancreas	COSMIC	VDVTPTYT	DEG_SCF_FBW7_1	933:940	Mutation altering degron motif	0.8166
p.K1329R	TCGA-D1-A103	UCEC	TCGA	IKENQ	DEG_APCC_KENBOX_2	1324:1328	Mutation blocking ubiquitination signal	0.75
p.K1329R	DO42312	UCEC	ICGC	IKENQ	DEG_APCC_KENBOX_2	1324:1328	Mutation blocking ubiquitination signal	0.75
p.K1325R	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	IKENQ	DEG_APCC_KENBOX_2	1324:1328	Mutation altering degron motif	0.7237
p.K889N	TCGA-BF-AAOU	SKCM	TCGA	NKENL	DEG_APCC_KENBOX_2	888:892	Mutation altering degron motif	0.6918
p.K889N	DO219460	SKCM	ICGC	NKENL	DEG_APCC_KENBOX_2	888:892	Mutation altering degron motif	0.6918
p.P100L	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	AATST	DEG_SPOP_SBC_1	104:108	Mutation blocking ubiquitination signal	0.6667
p.S897L	TCGA-DK-A6AW	BLCA	TCGA	PVSTPFLE	DEG_SCF_FBW7_2	895:902	Mutation altering degron motif	0.6556
p.S897L	DO48566	BLCA	ICGC	PVSTPFLE	DEG_SCF_FBW7_2	895:902	Mutation altering degron motif	0.6556
p.S271L	TCGA-SY-A9G5	BLCA	TCGA	LSTPSAS	DEG_SCF_FBW7_1	267:273	Mutation altering degron motif	0.6556
p.S271L	DO51906	BLCA	ICGC	LSTPSAS	DEG_SCF_FBW7_1	267:273	Mutation altering degron motif	0.6556
p.S928I	TCGA-L9-A7SV	LUAD	TCGA	VDVTPTYT	DEG_SCF_FBW7_1	933:940	Mutation blocking phosphorylation signal	0.6389
p.S928I	DO49875	LUAD	ICGC	VDVTPTYT	DEG_SCF_FBW7_1	933:940	Mutation blocking phosphorylation signal	0.6389
p.S116L	TCGA-AN-A046	BRCA	TCGA	AATST	DEG_SPOP_SBC_1	104:108	Mutation blocking phosphorylation signal	0.5556
p.S116L	TCGA-AP-A056	UCEC	TCGA	AATST	DEG_SPOP_SBC_1	104:108	Mutation blocking phosphorylation signal	0.5556
p.S116L	DO1285	BRCA	ICGC	AATST	DEG_SPOP_SBC_1	104:108	Mutation blocking phosphorylation signal	0.5556
p.S116L	DO43971	UCEC	ICGC	AATST	DEG_SPOP_SBC_1	104:108	Mutation blocking phosphorylation signal	0.5556
p.S1320G	DO42033	UCEC	ICGC	IKENQ	DEG_APCC_KENBOX_2	1324:1328	Mutation substituting flanking lysine	0.3333

Showing 1 to 20 of 133 entries

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Kaplan plot for BCOR in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BCOR

UniProt ID: Q6W2J9

Entrez ID: 54880

Protein name: BCL-6 corepressor (BCoR)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BCOR in