DegronMD

Uniprot ID: Q6W2J9

Source protein: BCL-6 corepressor

Source gene: BCOR

Class: DEG_SCF_FBW7_1

Location: 267:273

E3 ligase: FBXW7

DEGRON score: 0.9845

ASA_SCORE: 78.2

COIL: 0.9414

CONS_SCORE: 0.664

DSS_SCORE: 0.4224

HELIX: 0.0109

FCONS_SCORE: 0.9889

RIG_SCORE: 0.6262

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A283T	TCGA-BS-A0TC	UCEC	TCGA	LSTPSAS	DEG_SCF_FBW7_1	0.0556
p.A283T	DO42400	UCEC	ICGC	LSTPSAS	DEG_SCF_FBW7_1	0.0556
p.S271L	TCGA-SY-A9G5	BLCA	TCGA	LSTPSAS	DEG_SCF_FBW7_1	0.6556
p.S271L	DO51906	BLCA	ICGC	LSTPSAS	DEG_SCF_FBW7_1	0.6556
p.L279F	DO1076	BRCA	ICGC	LSTPSAS	DEG_SCF_FBW7_1	0.1667
p.R266M	DO27318	LUSC	ICGC	LSTPSAS	DEG_SCF_FBW7_1	0.3056
p.P264S	DO27931	ORCA	ICGC	LSTPSAS	DEG_SCF_FBW7_1	0.25
p.L279H	SIDM02024	Esophageal Carcinoma	GDSC	LSTPSAS	DEG_SCF_FBW7_1	0.1667
p.L279V	SIDM02024	Esophageal Carcinoma	GDSC	LSTPSAS	DEG_SCF_FBW7_1	0.1667
p.T275A	SW756	cervix	COSMIC	LSTPSAS	DEG_SCF_FBW7_1	0.2778
p.R268C	SNU-407	large_intestine	COSMIC	LSTPSAS	DEG_SCF_FBW7_1	0.8301
p.R257H	NCI-H1048	lung	COSMIC	LSTPSAS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6W2J9	BCL-6 corepressor	DEG_SCF_FBW7_1	267:273	LSTPSAS	FBXW7	0.9845	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons