DegronMD

Uniprot ID: Q6W2J9

Source protein: BCL-6 corepressor

Source gene: BCOR

Class: DEG_SCF_FBW7_2

Location: 895:902

E3 ligase: FBXW7

DEGRON score: 0.941

ASA_SCORE: 86.5625

COIL: 0.9163

CONS_SCORE: 0.509

DSS_SCORE: 0.5131

HELIX: 0.0361

FCONS_SCORE: 1.0419

RIG_SCORE: 0.7431

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S907N	TCGA-12-0818	GBM	TCGA	PVSTPFLE	DEG_SCF_FBW7_2	0.1944
p.S907N	DO12892	GBM	ICGC	PVSTPFLE	DEG_SCF_FBW7_2	0.1944
p.V912L	TCGA-49-AARO	LUAD	TCGA	PVSTPFLE	DEG_SCF_FBW7_2	0.0556
p.V912L	DO218924	LUAD	ICGC	PVSTPFLE	DEG_SCF_FBW7_2	0.0556
p.S897L	TCGA-DK-A6AW	BLCA	TCGA	PVSTPFLE	DEG_SCF_FBW7_2	0.6556
p.S897L	DO48566	BLCA	ICGC	PVSTPFLE	DEG_SCF_FBW7_2	0.6556
p.D908H	TCGA-OR-A5K6	ACC	TCGA	PVSTPFLE	DEG_SCF_FBW7_2	0.1667
p.D908N	TCGA-Z2-A8RT	SKCM	TCGA	PVSTPFLE	DEG_SCF_FBW7_2	0.1667
p.D908N	DO51301	SKCM	ICGC	PVSTPFLE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6W2J9	BCL-6 corepressor	DEG_SCF_FBW7_2	895:902	PVSTPFLE	FBXW7	0.941	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons