DegronMD

Uniprot ID: Q6W2J9

Source protein: BCL-6 corepressor

Source gene: BCOR

Class: DEG_SPOP_SBC_1

Location: 1435:1439

E3 ligase: SPOP

DEGRON score: 0.935

ASA_SCORE: 80.04

COIL: 0.9236

CONS_SCORE: 0.4602

DSS_SCORE: 0.7674

HELIX: 0.0492

FCONS_SCORE: 0.909

RIG_SCORE: 0.5753

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1447H	TCGA-AX-A06H	UCEC	TCGA	PCSSS	DEG_SPOP_SBC_1	0.1111
p.N1425S	DO223879	AML	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.N1425S	DO234452	BPLL	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.N1425S	DO233964	BPLL	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.N1425S	DO51604	CESC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.N1425S	DO219888	DLBC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.N1425S	DO218941	LUAD	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.N1425S	DO25068	LUAD	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.N1425S	DO23976	LUAD	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.N1425S	DO52658	MALY	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.N1425S	DO33680	PACA	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.N1425S	DO219775	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.N1425S	DO219774	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.N1425S	DO219768	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.N1425S	DO219765	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.N1425S	DO48172	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.N1425S	DO40843	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.N1425S	DO50081	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.N1425S	DO40924	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.N1425S	DO42177	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.N1425S	DO42023	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.N1425S	DO41002	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.N1425S	DO42304	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.N1425S	DO43001	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.N1425S	DO43170	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.N1425S	DO52419	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.N1425S	DO41704	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.N1425S	DO41686	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.N1425S	DO41590	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.N1425S	DO41879	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.N1425S	DO41823	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.N1425S	DO43915	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.N1425S	DO41205	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.N1425S	DO42592	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.N1425S	DO42432	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.N1425S	DO42841	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.N1425S	DO41446	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.N1425S	DO42721	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.N1425S	DO42681	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.N1425S	DO229086	UTCA	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.L1425M	DO229022	LICA	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75385	Serine/threonine-protein kinase ULK1	DEG_SPOP_SBC_1	407:411	PCSSS	SPOP	0.9876	More...
Q03167	Transforming growth factor beta receptor type 3	DEG_SPOP_SBC_1	844:848	PCSSS	SPOP	0.998	More...
Q5T749	Keratinocyte proline-rich protein	DEG_SPOP_SBC_1	277:281	PCSSS	SPOP	0.9032	More...
Q6W2J9	BCL-6 corepressor	DEG_SPOP_SBC_1	1435:1439	PCSSS	SPOP	0.935	More...
Q8IYX3	Coiled-coil domain-containing protein 116	DEG_SPOP_SBC_1	403:407	PCSSS	SPOP	0.772	More...
Q8NBR6	Ubiquitin carboxyl-terminal hydrolase MINDY-2	DEG_SPOP_SBC_1	78:82	PCSSS	SPOP	0.992	More...
Q8WZ75	Roundabout homolog 4	DEG_SPOP_SBC_1	617:621	PCSSS	SPOP	0.8344	More...
Q99941	Cyclic AMP-dependent transcription factor ATF-6 beta	DEG_SPOP_SBC_1	94:98	PCSSS	SPOP	0.9963	More...
Q9NWZ8	Gem-associated protein 8	DEG_SPOP_SBC_1	87:91	PCSSS	SPOP	0.9101	More...
Q8TC76	Protein FAM110B	DEG_SPOP_SBC_1	216:220	PCSSS	SPOP	0.9592	More...
Q9BU23	Lipase maturation factor 2	DEG_SPOP_SBC_1	695:699	PCSSS	SPOP	0.9238	More...
Q9Y5P3	Retinoic acid-induced protein 2	DEG_SPOP_SBC_1	145:149	PCSSS	SPOP	0.7764	More...
Q7Z736	Pleckstrin homology domain-containing family H member 3	DEG_SPOP_SBC_1	755:759	PCSSS	SPOP	0.8988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PCSSS

Degron related mutations and impact score

Drug responses associated with BCOR mutations

All proteins holding degron of PCSSS