DegronMD

Uniprot ID: Q8TC76

Source protein: Protein FAM110B

Source gene: FAM110B

Class: DEG_SPOP_SBC_1

Location: 216:220

E3 ligase: SPOP

DEGRON score: 0.9592

ASA_SCORE: 82.92

COIL: 0.9386

CONS_SCORE: 0.6493

DSS_SCORE: 0.5012

HELIX: 0.0272

FCONS_SCORE: 1.2167

RIG_SCORE: 0.6507

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V209L	TCGA-21-1070	LUSC	TCGA	PCSSS	DEG_SPOP_SBC_1	0.1389
p.V209L	DO27088	LUSC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.1389
p.P222H	TCGA-39-5016	LUSC	TCGA	PCSSS	DEG_SPOP_SBC_1	0.2778
p.P222H	DO26701	LUSC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.2778
p.S220P	TCGA-A5-A1OF	UCEC	TCGA	PCSSS	DEG_SPOP_SBC_1	0.6752
p.S220P	DO42568	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.6752
p.P211H	TCGA-AP-A054	UCEC	TCGA	PCSSS	DEG_SPOP_SBC_1	0.1944
p.P211H	DO42256	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.1944
p.S208R	TCGA-AX-A1C5	UCEC	TCGA	PCSSS	DEG_SPOP_SBC_1	0.1111
p.S208R	DO41422	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.1111
p.V206A	TCGA-CV-7247	HNSC	TCGA	PCSSS	DEG_SPOP_SBC_1	0.0556
p.V206A	DO14982	HNSC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.S220C	TCGA-NJ-A4YG	LUAD	TCGA	PCSSS	DEG_SPOP_SBC_1	0.7541
p.S220C	DO218941	LUAD	ICGC	PCSSS	DEG_SPOP_SBC_1	0.7541
p.L212F	DO230335	COCA	ICGC	PCSSS	DEG_SPOP_SBC_1	0.2222
p.P228S	DO220862	MELA	ICGC	PCSSS	DEG_SPOP_SBC_1	0.1111
p.V209M	SIDM00280	Gastric Carcinoma	GDSC	PCSSS	DEG_SPOP_SBC_1	0.1389
p.V209M	ACH-000560	Gastric Cancer	CCLE	PCSSS	DEG_SPOP_SBC_1	0.1389
p.V209M	ECC10	stomach	COSMIC	PCSSS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75385	Serine/threonine-protein kinase ULK1	DEG_SPOP_SBC_1	407:411	PCSSS	SPOP	0.9876	More...
Q03167	Transforming growth factor beta receptor type 3	DEG_SPOP_SBC_1	844:848	PCSSS	SPOP	0.998	More...
Q5T749	Keratinocyte proline-rich protein	DEG_SPOP_SBC_1	277:281	PCSSS	SPOP	0.9032	More...
Q6W2J9	BCL-6 corepressor	DEG_SPOP_SBC_1	1435:1439	PCSSS	SPOP	0.935	More...
Q8IYX3	Coiled-coil domain-containing protein 116	DEG_SPOP_SBC_1	403:407	PCSSS	SPOP	0.772	More...
Q8NBR6	Ubiquitin carboxyl-terminal hydrolase MINDY-2	DEG_SPOP_SBC_1	78:82	PCSSS	SPOP	0.992	More...
Q8WZ75	Roundabout homolog 4	DEG_SPOP_SBC_1	617:621	PCSSS	SPOP	0.8344	More...
Q99941	Cyclic AMP-dependent transcription factor ATF-6 beta	DEG_SPOP_SBC_1	94:98	PCSSS	SPOP	0.9963	More...
Q9NWZ8	Gem-associated protein 8	DEG_SPOP_SBC_1	87:91	PCSSS	SPOP	0.9101	More...
Q8TC76	Protein FAM110B	DEG_SPOP_SBC_1	216:220	PCSSS	SPOP	0.9592	More...
Q9BU23	Lipase maturation factor 2	DEG_SPOP_SBC_1	695:699	PCSSS	SPOP	0.9238	More...
Q9Y5P3	Retinoic acid-induced protein 2	DEG_SPOP_SBC_1	145:149	PCSSS	SPOP	0.7764	More...
Q7Z736	Pleckstrin homology domain-containing family H member 3	DEG_SPOP_SBC_1	755:759	PCSSS	SPOP	0.8988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons