DegronMD - Q5T749(KPRP)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P368L	TCGA-43-2581	LUSC	TCGA	LRPHVE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.2778
p.P368L	DO26602	LUSC	ICGC	LRPHVE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.2778
p.E276D	TCGA-43-5668	LUSC	TCGA	PCSSS	DEG_SPOP_SBC_1	277:281	Mutation rewiring degron network	0.3056
p.E276D	DO26608	LUSC	ICGC	PCSSS	DEG_SPOP_SBC_1	277:281	Mutation rewiring degron network	0.3056
p.R267C	TCGA-44-8117	LUAD	TCGA	PCSSS	DEG_SPOP_SBC_1	277:281	Mutation rewiring degron network	0.0556
p.R267C	DO24028	LUAD	ICGC	PCSSS	DEG_SPOP_SBC_1	277:281	Mutation rewiring degron network	0.0556
p.L283M	TCGA-91-6829	LUAD	TCGA	PCSSS	DEG_SPOP_SBC_1	277:281	Mutation rewiring degron network	0.2778
p.L283M	DO23564	LUAD	ICGC	PCSSS	DEG_SPOP_SBC_1	277:281	Mutation rewiring degron network	0.2778
p.P372T	TCGA-98-A538	LUSC	TCGA	LRPHVE	LIG_APCC_ABBA_1	370:375	Mutation altering degron motif	0.7031
p.P372T	DO222913	BTCA	ICGC	LRPHVE	LIG_APCC_ABBA_1	370:375	Mutation altering degron motif	0.7031
p.P372T	DO219177	LUSC	ICGC	LRPHVE	LIG_APCC_ABBA_1	370:375	Mutation altering degron motif	0.7031
p.G290C	TCGA-A5-A0G2	UCEC	TCGA	PCSSS	DEG_SPOP_SBC_1	277:281	Mutation rewiring degron network	0.0833
p.G290C	DO41235	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	277:281	Mutation rewiring degron network	0.0833
p.R267H	TCGA-A5-A0GP	UCEC	TCGA	PCSSS	DEG_SPOP_SBC_1	277:281	Mutation rewiring degron network	0.0556
p.R267H	DO41109	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	277:281	Mutation rewiring degron network	0.0556
p.R267H	SIDM00660	Colorectal Carcinoma	GDSC	PCSSS	DEG_SPOP_SBC_1	277:281	Mutation rewiring degron network	0.0556
p.R267H	ACH-000985	Colon/Colorectal Cancer	CCLE	PCSSS	DEG_SPOP_SBC_1	277:281	Mutation rewiring degron network	0.0556
p.R267H	ACH-001609	Brain Cancer	CCLE	PCSSS	DEG_SPOP_SBC_1	277:281	Mutation rewiring degron network	0.0556
p.R267H	LS-411N	large intestine	COSMIC	PCSSS	DEG_SPOP_SBC_1	277:281	Mutation rewiring degron network	0.0556
p.P271Q	TCGA-A7-A4SE	BRCA	TCGA	PCSSS	DEG_SPOP_SBC_1	277:281	Mutation rewiring degron network	0.1667
p.P271Q	DO44141	BRCA	ICGC	PCSSS	DEG_SPOP_SBC_1	277:281	Mutation rewiring degron network	0.1667
p.P271Q	SIDM00143	Small Cell Lung Carcinoma	GDSC	PCSSS	DEG_SPOP_SBC_1	277:281	Mutation rewiring degron network	0.1667
p.P271Q	ACH-000803	Lung Cancer	CCLE	PCSSS	DEG_SPOP_SBC_1	277:281	Mutation rewiring degron network	0.1667
p.P271Q	COLO-668	lung	COSMIC	PCSSS	DEG_SPOP_SBC_1	277:281	Mutation rewiring degron network	0.1667
p.R267G	TCGA-AC-A8OP	BRCA	TCGA	PCSSS	DEG_SPOP_SBC_1	277:281	Mutation rewiring degron network	0.0556
p.R267G	DO50032	BRCA	ICGC	PCSSS	DEG_SPOP_SBC_1	277:281	Mutation rewiring degron network	0.0556
p.A365T	TCGA-AX-A1CE	UCEC	TCGA	LRPHVE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.1944
p.A365T	TCGA-G9-6336	PRAD	TCGA	LRPHVE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.1944
p.A365T	TCGA-IK-8125	LGG	TCGA	LRPHVE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.1944
p.A365T	DO234209	ESAD	ICGC	LRPHVE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.1944
p.A365T	DO22379	LGG	ICGC	LRPHVE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.1944
p.A365T	DO51068	PRAD	ICGC	LRPHVE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.1944
p.A365T	DO36372	PRAD	ICGC	LRPHVE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.1944
p.A365T	DO42280	UCEC	ICGC	LRPHVE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.1944
p.V374I	TCGA-BH-A0BR	BRCA	TCGA	LRPHVE	LIG_APCC_ABBA_1	370:375	Mutation altering degron motif	0.5965
p.V374I	DO2966	BRCA	ICGC	LRPHVE	LIG_APCC_ABBA_1	370:375	Mutation altering degron motif	0.5965
p.R377H	TCGA-D1-A167	UCEC	TCGA	LRPHVE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.2778
p.R377H	DO229389	BTCA	ICGC	LRPHVE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.2778
p.R377H	DO40978	UCEC	ICGC	LRPHVE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.2778
p.R274C	TCGA-D1-A16E	UCEC	TCGA	PCSSS	DEG_SPOP_SBC_1	277:281	Mutation rewiring degron network	0.25
p.R274C	TCGA-N5-A4RO	UCS	TCGA	PCSSS	DEG_SPOP_SBC_1	277:281	Mutation rewiring degron network	0.25
p.R274C	DO41002	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	277:281	Mutation rewiring degron network	0.25
p.S366F	TCGA-DA-A1I1	SKCM	TCGA	LRPHVE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.2222
p.S366F	DO37966	SKCM	ICGC	LRPHVE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.2222
p.P384L	TCGA-EE-A2MD	SKCM	TCGA	LRPHVE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.0833
p.P384L	TCGA-EE-A2ML	SKCM	TCGA	LRPHVE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.0833
p.P384L	DO222429	MELA	ICGC	LRPHVE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.0833
p.P384L	DO222434	MELA	ICGC	LRPHVE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.0833
p.P384L	DO37851	SKCM	ICGC	LRPHVE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.0833
p.P384L	DO37408	SKCM	ICGC	LRPHVE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.0833
p.E375Q	TCGA-EW-A1J5	BRCA	TCGA	LRPHVE	LIG_APCC_ABBA_1	370:375	Mutation altering degron motif	0.6744
p.E375Q	DO6144	BRCA	ICGC	LRPHVE	LIG_APCC_ABBA_1	370:375	Mutation altering degron motif	0.6744
p.G364V	TCGA-SW-A7EA	STAD	TCGA	LRPHVE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.1667
p.G364V	DO51749	STAD	ICGC	LRPHVE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.1667
p.R371M	DO222817	BTCA	ICGC	LRPHVE	LIG_APCC_ABBA_1	370:375	Mutation altering degron motif	0.7521
p.C269R	DO228203	LICA	ICGC	PCSSS	DEG_SPOP_SBC_1	277:281	Mutation rewiring degron network	0.1111
p.Q360H	DO229029	LICA	ICGC	LRPHVE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.0556
p.C269F	DO229028	LICA	ICGC	PCSSS	DEG_SPOP_SBC_1	277:281	Mutation rewiring degron network	0.1111
p.R274L	DO229025	LICA	ICGC	PCSSS	DEG_SPOP_SBC_1	277:281	Mutation rewiring degron network	0.25
p.S381I	DO229038	LICA	ICGC	LRPHVE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.1667
p.L370M	SIDM02066	Colorectal Carcinoma	GDSC	LRPHVE	LIG_APCC_ABBA_1	370:375	Mutation altering degron motif	0.5999
p.P271L	SIDM00251	Gastric Carcinoma	GDSC	PCSSS	DEG_SPOP_SBC_1	277:281	Mutation rewiring degron network	0.1667
p.P271L	SIDM00024	Non-Cancerous	GDSC	PCSSS	DEG_SPOP_SBC_1	277:281	Mutation rewiring degron network	0.1667
p.P271L	TGBC11TKB	stomach	COSMIC	PCSSS	DEG_SPOP_SBC_1	277:281	Mutation rewiring degron network	0.1667
p.L379F	SIDM00516	Melanoma	GDSC	LRPHVE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.2222
p.L379F	ACH-002166	Skin Cancer	CCLE	LRPHVE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.2222
p.L379F	MZ7-mel	skin	COSMIC	LRPHVE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.2222
p.S279Y	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	PCSSS	DEG_SPOP_SBC_1	277:281	Mutation altering degron motif	0.712
p.S279Y	ACH-000900	Lung Cancer	CCLE	PCSSS	DEG_SPOP_SBC_1	277:281	Mutation altering degron motif	0.712
p.S279Y	NCI-H23	lung	COSMIC	PCSSS	DEG_SPOP_SBC_1	277:281	Mutation altering degron motif	0.712
p.R377L	SIDM01432	Kidney Carcinoma	GDSC	LRPHVE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.2778
p.R377L	ACH-000495	Kidney Cancer	CCLE	LRPHVE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.2778
p.R377C	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	LRPHVE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.2778
p.R377C	ACH-000726	Esophageal Cancer	CCLE	LRPHVE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KPRP

UniProt ID: Q5T749

Entrez ID: 448834

Protein name: Keratinocyte proline-rich protein (hKPRP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KPRP in