DegronMD

Uniprot ID: Q5T749

Source protein: Keratinocyte proline-rich protein

Source gene: KPRP

Class: LIG_APCC_ABBA_1

Location: 370:375

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5785

ASA_SCORE: 112.5833

COIL: 0.9328

CONS_SCORE: 0.7481

DSS_SCORE: 0.388

HELIX: 0.0123

FCONS_SCORE: 0.9521

RIG_SCORE: 0.6393

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P368L	TCGA-43-2581	LUSC	TCGA	LRPHVE	LIG_APCC_ABBA_1	0.2778
p.P368L	DO26602	LUSC	ICGC	LRPHVE	LIG_APCC_ABBA_1	0.2778
p.P372T	TCGA-98-A538	LUSC	TCGA	LRPHVE	LIG_APCC_ABBA_1	0.7031
p.P372T	DO222913	BTCA	ICGC	LRPHVE	LIG_APCC_ABBA_1	0.7031
p.P372T	DO219177	LUSC	ICGC	LRPHVE	LIG_APCC_ABBA_1	0.7031
p.A365T	TCGA-AX-A1CE	UCEC	TCGA	LRPHVE	LIG_APCC_ABBA_1	0.1944
p.A365T	TCGA-G9-6336	PRAD	TCGA	LRPHVE	LIG_APCC_ABBA_1	0.1944
p.A365T	TCGA-IK-8125	LGG	TCGA	LRPHVE	LIG_APCC_ABBA_1	0.1944
p.A365T	DO234209	ESAD	ICGC	LRPHVE	LIG_APCC_ABBA_1	0.1944
p.A365T	DO22379	LGG	ICGC	LRPHVE	LIG_APCC_ABBA_1	0.1944
p.A365T	DO51068	PRAD	ICGC	LRPHVE	LIG_APCC_ABBA_1	0.1944
p.A365T	DO36372	PRAD	ICGC	LRPHVE	LIG_APCC_ABBA_1	0.1944
p.A365T	DO42280	UCEC	ICGC	LRPHVE	LIG_APCC_ABBA_1	0.1944
p.V374I	TCGA-BH-A0BR	BRCA	TCGA	LRPHVE	LIG_APCC_ABBA_1	0.5965
p.V374I	DO2966	BRCA	ICGC	LRPHVE	LIG_APCC_ABBA_1	0.5965
p.R377H	TCGA-D1-A167	UCEC	TCGA	LRPHVE	LIG_APCC_ABBA_1	0.2778
p.R377H	DO229389	BTCA	ICGC	LRPHVE	LIG_APCC_ABBA_1	0.2778
p.R377H	DO40978	UCEC	ICGC	LRPHVE	LIG_APCC_ABBA_1	0.2778
p.S366F	TCGA-DA-A1I1	SKCM	TCGA	LRPHVE	LIG_APCC_ABBA_1	0.2222
p.S366F	DO37966	SKCM	ICGC	LRPHVE	LIG_APCC_ABBA_1	0.2222
p.P384L	TCGA-EE-A2MD	SKCM	TCGA	LRPHVE	LIG_APCC_ABBA_1	0.0833
p.P384L	TCGA-EE-A2ML	SKCM	TCGA	LRPHVE	LIG_APCC_ABBA_1	0.0833
p.P384L	DO222429	MELA	ICGC	LRPHVE	LIG_APCC_ABBA_1	0.0833
p.P384L	DO222434	MELA	ICGC	LRPHVE	LIG_APCC_ABBA_1	0.0833
p.P384L	DO37851	SKCM	ICGC	LRPHVE	LIG_APCC_ABBA_1	0.0833
p.P384L	DO37408	SKCM	ICGC	LRPHVE	LIG_APCC_ABBA_1	0.0833
p.E375Q	TCGA-EW-A1J5	BRCA	TCGA	LRPHVE	LIG_APCC_ABBA_1	0.6744
p.E375Q	DO6144	BRCA	ICGC	LRPHVE	LIG_APCC_ABBA_1	0.6744
p.G364V	TCGA-SW-A7EA	STAD	TCGA	LRPHVE	LIG_APCC_ABBA_1	0.1667
p.G364V	DO51749	STAD	ICGC	LRPHVE	LIG_APCC_ABBA_1	0.1667
p.R371M	DO222817	BTCA	ICGC	LRPHVE	LIG_APCC_ABBA_1	0.7521
p.Q360H	DO229029	LICA	ICGC	LRPHVE	LIG_APCC_ABBA_1	0.0556
p.S381I	DO229038	LICA	ICGC	LRPHVE	LIG_APCC_ABBA_1	0.1667
p.L370M	SIDM02066	Colorectal Carcinoma	GDSC	LRPHVE	LIG_APCC_ABBA_1	0.5999
p.L379F	SIDM00516	Melanoma	GDSC	LRPHVE	LIG_APCC_ABBA_1	0.2222
p.L379F	ACH-002166	Skin Cancer	CCLE	LRPHVE	LIG_APCC_ABBA_1	0.2222
p.L379F	MZ7-mel	skin	COSMIC	LRPHVE	LIG_APCC_ABBA_1	0.2222
p.R377L	SIDM01432	Kidney Carcinoma	GDSC	LRPHVE	LIG_APCC_ABBA_1	0.2778
p.R377L	ACH-000495	Kidney Cancer	CCLE	LRPHVE	LIG_APCC_ABBA_1	0.2778
p.R377C	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	LRPHVE	LIG_APCC_ABBA_1	0.2778
p.R377C	ACH-000726	Esophageal Cancer	CCLE	LRPHVE	LIG_APCC_ABBA_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRPHVE

Degron related mutations and impact score

Drug responses associated with KPRP mutations

All proteins holding degron of LRPHVE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T749	Keratinocyte proline-rich protein	LIG_APCC_ABBA_1	370:375	LRPHVE	APC,CDC20,FZR1	0.5785	More...