DegronMD

Uniprot ID: Q5T749

Source protein: Keratinocyte proline-rich protein

Source gene: KPRP

Class: DEG_SPOP_SBC_1

Location: 277:281

E3 ligase: SPOP

DEGRON score: 0.9032

ASA_SCORE: 84.18

COIL: 0.9564

CONS_SCORE: 0.7291

DSS_SCORE: 0.4018

HELIX: 0.03

FCONS_SCORE: 0.8649

RIG_SCORE: 0.6615

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E276D	TCGA-43-5668	LUSC	TCGA	PCSSS	DEG_SPOP_SBC_1	0.3056
p.E276D	DO26608	LUSC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.3056
p.R267C	TCGA-44-8117	LUAD	TCGA	PCSSS	DEG_SPOP_SBC_1	0.0556
p.R267C	DO24028	LUAD	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.L283M	TCGA-91-6829	LUAD	TCGA	PCSSS	DEG_SPOP_SBC_1	0.2778
p.L283M	DO23564	LUAD	ICGC	PCSSS	DEG_SPOP_SBC_1	0.2778
p.G290C	TCGA-A5-A0G2	UCEC	TCGA	PCSSS	DEG_SPOP_SBC_1	0.0833
p.G290C	DO41235	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0833
p.R267H	TCGA-A5-A0GP	UCEC	TCGA	PCSSS	DEG_SPOP_SBC_1	0.0556
p.R267H	DO41109	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.R267H	SIDM00660	Colorectal Carcinoma	GDSC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.R267H	ACH-000985	Colon/Colorectal Cancer	CCLE	PCSSS	DEG_SPOP_SBC_1	0.0556
p.R267H	ACH-001609	Brain Cancer	CCLE	PCSSS	DEG_SPOP_SBC_1	0.0556
p.R267H	LS-411N	large_intestine	COSMIC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.P271Q	TCGA-A7-A4SE	BRCA	TCGA	PCSSS	DEG_SPOP_SBC_1	0.1667
p.P271Q	DO44141	BRCA	ICGC	PCSSS	DEG_SPOP_SBC_1	0.1667
p.P271Q	SIDM00143	Small Cell Lung Carcinoma	GDSC	PCSSS	DEG_SPOP_SBC_1	0.1667
p.P271Q	ACH-000803	Lung Cancer	CCLE	PCSSS	DEG_SPOP_SBC_1	0.1667
p.P271Q	COLO-668	lung	COSMIC	PCSSS	DEG_SPOP_SBC_1	0.1667
p.R267G	TCGA-AC-A8OP	BRCA	TCGA	PCSSS	DEG_SPOP_SBC_1	0.0556
p.R267G	DO50032	BRCA	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.R274C	TCGA-D1-A16E	UCEC	TCGA	PCSSS	DEG_SPOP_SBC_1	0.25
p.R274C	TCGA-N5-A4RO	UCS	TCGA	PCSSS	DEG_SPOP_SBC_1	0.25
p.R274C	DO41002	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.25
p.C269R	DO228203	LICA	ICGC	PCSSS	DEG_SPOP_SBC_1	0.1111
p.C269F	DO229028	LICA	ICGC	PCSSS	DEG_SPOP_SBC_1	0.1111
p.R274L	DO229025	LICA	ICGC	PCSSS	DEG_SPOP_SBC_1	0.25
p.P271L	SIDM00251	Gastric Carcinoma	GDSC	PCSSS	DEG_SPOP_SBC_1	0.1667
p.P271L	SIDM00024	Non-Cancerous	GDSC	PCSSS	DEG_SPOP_SBC_1	0.1667
p.P271L	TGBC11TKB	stomach	COSMIC	PCSSS	DEG_SPOP_SBC_1	0.1667
p.S279Y	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	PCSSS	DEG_SPOP_SBC_1	0.712
p.S279Y	ACH-000900	Lung Cancer	CCLE	PCSSS	DEG_SPOP_SBC_1	0.712
p.S279Y	NCI-H23	lung	COSMIC	PCSSS	DEG_SPOP_SBC_1	0.712

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75385	Serine/threonine-protein kinase ULK1	DEG_SPOP_SBC_1	407:411	PCSSS	SPOP	0.9876	More...
Q03167	Transforming growth factor beta receptor type 3	DEG_SPOP_SBC_1	844:848	PCSSS	SPOP	0.998	More...
Q5T749	Keratinocyte proline-rich protein	DEG_SPOP_SBC_1	277:281	PCSSS	SPOP	0.9032	More...
Q6W2J9	BCL-6 corepressor	DEG_SPOP_SBC_1	1435:1439	PCSSS	SPOP	0.935	More...
Q8IYX3	Coiled-coil domain-containing protein 116	DEG_SPOP_SBC_1	403:407	PCSSS	SPOP	0.772	More...
Q8NBR6	Ubiquitin carboxyl-terminal hydrolase MINDY-2	DEG_SPOP_SBC_1	78:82	PCSSS	SPOP	0.992	More...
Q8WZ75	Roundabout homolog 4	DEG_SPOP_SBC_1	617:621	PCSSS	SPOP	0.8344	More...
Q99941	Cyclic AMP-dependent transcription factor ATF-6 beta	DEG_SPOP_SBC_1	94:98	PCSSS	SPOP	0.9963	More...
Q9NWZ8	Gem-associated protein 8	DEG_SPOP_SBC_1	87:91	PCSSS	SPOP	0.9101	More...
Q8TC76	Protein FAM110B	DEG_SPOP_SBC_1	216:220	PCSSS	SPOP	0.9592	More...
Q9BU23	Lipase maturation factor 2	DEG_SPOP_SBC_1	695:699	PCSSS	SPOP	0.9238	More...
Q9Y5P3	Retinoic acid-induced protein 2	DEG_SPOP_SBC_1	145:149	PCSSS	SPOP	0.7764	More...
Q7Z736	Pleckstrin homology domain-containing family H member 3	DEG_SPOP_SBC_1	755:759	PCSSS	SPOP	0.8988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PCSSS

Degron related mutations and impact score

Drug responses associated with KPRP mutations

All proteins holding degron of PCSSS