DegronMD

Uniprot ID: Q7Z736

Source protein: Pleckstrin homology domain-containing family H member 3

Source gene: PLEKHH3

Class: DEG_SPOP_SBC_1

Location: 755:759

E3 ligase: SPOP

DEGRON score: 0.8988

ASA_SCORE: 78.48

COIL: 0.86

CONS_SCORE: 0.3553

DSS_SCORE: 0.6905

HELIX: 0.041

FCONS_SCORE: 0.8141

RIG_SCORE: 0.5303

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T769P	TCGA-19-1387	GBM	TCGA	PCSSS	DEG_SPOP_SBC_1	0.0556
p.T769P	DO11573	GBM	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.D768H	TCGA-95-8039	LUAD	TCGA	PCSSS	DEG_SPOP_SBC_1	0.0833
p.D768H	DO51197	LUAD	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0833
p.A748D	TCGA-AX-A06F	UCEC	TCGA	PCSSS	DEG_SPOP_SBC_1	0.1389
p.A748D	DO41752	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.1389
p.S757C	TCGA-CG-5727	STAD	TCGA	PCSSS	DEG_SPOP_SBC_1	0.7541
p.S757C	DO38511	STAD	ICGC	PCSSS	DEG_SPOP_SBC_1	0.7541
p.P750T	TCGA-CJ-4903	KIRC	TCGA	PCSSS	DEG_SPOP_SBC_1	0.1944
p.P750T	DO18819	KIRC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.1944
p.P750L	TCGA-CK-4951	COAD	TCGA	PCSSS	DEG_SPOP_SBC_1	0.1944
p.P750L	DO10582	COAD	ICGC	PCSSS	DEG_SPOP_SBC_1	0.1944
p.P762Q	TCGA-ER-A19E	SKCM	TCGA	PCSSS	DEG_SPOP_SBC_1	0.25
p.P762Q	DO47542	SKCM	ICGC	PCSSS	DEG_SPOP_SBC_1	0.25
p.A748T	TCGA-FD-A6TF	BLCA	TCGA	PCSSS	DEG_SPOP_SBC_1	0.1389
p.A748T	DO51880	BLCA	ICGC	PCSSS	DEG_SPOP_SBC_1	0.1389
p.D768Y	TCGA-G2-A2EO	BLCA	TCGA	PCSSS	DEG_SPOP_SBC_1	0.0833
p.D768Y	DO456	BLCA	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0833
p.P752L	DO50499	BOCA	ICGC	PCSSS	DEG_SPOP_SBC_1	0.25
p.P761S	SIDM00637	B-Cell Non-Hodgkin's Lymphoma	GDSC	PCSSS	DEG_SPOP_SBC_1	0.2778
p.P762A	SIDM00902	Non-Small Cell Lung Carcinoma	GDSC	PCSSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75385	Serine/threonine-protein kinase ULK1	DEG_SPOP_SBC_1	407:411	PCSSS	SPOP	0.9876	More...
Q03167	Transforming growth factor beta receptor type 3	DEG_SPOP_SBC_1	844:848	PCSSS	SPOP	0.998	More...
Q5T749	Keratinocyte proline-rich protein	DEG_SPOP_SBC_1	277:281	PCSSS	SPOP	0.9032	More...
Q6W2J9	BCL-6 corepressor	DEG_SPOP_SBC_1	1435:1439	PCSSS	SPOP	0.935	More...
Q8IYX3	Coiled-coil domain-containing protein 116	DEG_SPOP_SBC_1	403:407	PCSSS	SPOP	0.772	More...
Q8NBR6	Ubiquitin carboxyl-terminal hydrolase MINDY-2	DEG_SPOP_SBC_1	78:82	PCSSS	SPOP	0.992	More...
Q8WZ75	Roundabout homolog 4	DEG_SPOP_SBC_1	617:621	PCSSS	SPOP	0.8344	More...
Q99941	Cyclic AMP-dependent transcription factor ATF-6 beta	DEG_SPOP_SBC_1	94:98	PCSSS	SPOP	0.9963	More...
Q9NWZ8	Gem-associated protein 8	DEG_SPOP_SBC_1	87:91	PCSSS	SPOP	0.9101	More...
Q8TC76	Protein FAM110B	DEG_SPOP_SBC_1	216:220	PCSSS	SPOP	0.9592	More...
Q9BU23	Lipase maturation factor 2	DEG_SPOP_SBC_1	695:699	PCSSS	SPOP	0.9238	More...
Q9Y5P3	Retinoic acid-induced protein 2	DEG_SPOP_SBC_1	145:149	PCSSS	SPOP	0.7764	More...
Q7Z736	Pleckstrin homology domain-containing family H member 3	DEG_SPOP_SBC_1	755:759	PCSSS	SPOP	0.8988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons