DegronMD - Q99941(ATF6B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V174I	TCGA-AX-A2HJ	UCEC	TCGA	ADSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.0833
p.S99F	TCGA-DK-A3X1	BLCA	TCGA	PCSSS	DEG_SPOP_SBC_1	94:98	Mutation rewiring degron network	0.3056
p.V254I	TCGA-DK-AA6X	BLCA	TCGA	PPSTT	DEG_SPOP_SBC_1	262:266	Mutation rewiring degron network	0.1111
p.S179F	TCGA-EE-A3J5	SKCM	TCGA	ADSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.2222
p.S89Y	TCGA-EO-A22R	UCEC	TCGA	PCSSS	DEG_SPOP_SBC_1	94:98	Mutation blocking phosphorylation signal	0.6389
p.S89Y	TCGA-EO-A22R	UCEC	TCGA	LPIFPD	LIG_APCC_ABBA_1	79:84	Mutation blocking phosphorylation signal	0.6389
p.L181F	TCGA-FW-A3R5	SKCM	TCGA	ADSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.2778
p.S173F	TCGA-FW-A3R5	SKCM	TCGA	ADSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.0556
p.L269M	TCGA-MN-A4N4	LUAD	TCGA	PPSTT	DEG_SPOP_SBC_1	262:266	Mutation rewiring degron network	0.25
p.S105L	TCGA-SJ-A6ZI	UCEC	TCGA	PCSSS	DEG_SPOP_SBC_1	94:98	Mutation rewiring degron network	0.1389
p.S96F	DO447	BLCA	ICGC	PCSSS	DEG_SPOP_SBC_1	94:98	Mutation altering degron motif	0.7982
p.P254L	DO233819	GACA	ICGC	PPSTT	DEG_SPOP_SBC_1	262:266	Mutation rewiring degron network	0.1111
p.D81N	DO229177	LMS	ICGC	LPIFPD	LIG_APCC_ABBA_1	79:84	Mutation altering degron motif	0.6932
p.L266M	DO26250	LUAD	ICGC	PPSTT	DEG_SPOP_SBC_1	262:266	Mutation altering degron motif	0.711
p.S182F	DO220880	MELA	ICGC	ADSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.3056
p.S268F	DO220906	MELA	ICGC	PPSTT	DEG_SPOP_SBC_1	262:266	Mutation rewiring degron network	0.2778
p.E70G	DO46591	OV	ICGC	LPIFPD	LIG_APCC_ABBA_1	79:84	Mutation rewiring degron network	0.0833
p.L178F	DO37406	SKCM	ICGC	ADSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.1944
p.S176F	DO47331	SKCM	ICGC	ADSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.1389
p.S102L	DO219784	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	94:98	Mutation rewiring degron network	0.2222
p.S86Y	DO42713	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	94:98	Mutation rewiring degron network	0.1111
p.S86Y	DO42713	UCEC	ICGC	LPIFPD	LIG_APCC_ABBA_1	79:84	Mutation rewiring degron network	0.2778
p.A260S	SIDM01043	Other Sarcomas	GDSC	PPSTT	DEG_SPOP_SBC_1	262:266	Mutation rewiring degron network	0.2778
p.A260S	SIDM00938	Breast Carcinoma	GDSC	PPSTT	DEG_SPOP_SBC_1	262:266	Mutation rewiring degron network	0.2778
p.A260S	SIDM00197	Ewing's Sarcoma	GDSC	PPSTT	DEG_SPOP_SBC_1	262:266	Mutation rewiring degron network	0.2778
p.A260S	SIDM00686	Endometrial Carcinoma	GDSC	PPSTT	DEG_SPOP_SBC_1	262:266	Mutation rewiring degron network	0.2778
p.A260S	SIDM00739	Non-Small Cell Lung Carcinoma	GDSC	PPSTT	DEG_SPOP_SBC_1	262:266	Mutation rewiring degron network	0.2778
p.A260S	SIDM00747	Non-Small Cell Lung Carcinoma	GDSC	PPSTT	DEG_SPOP_SBC_1	262:266	Mutation rewiring degron network	0.2778
p.A260S	SIDM00508	Squamous Cell Lung Carcinoma	GDSC	PPSTT	DEG_SPOP_SBC_1	262:266	Mutation rewiring degron network	0.2778
p.S187I	SIDM00660	Colorectal Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	183:187	Mutation altering degron motif	0.7341
p.S187I	ACH-000985	Colon/Colorectal Cancer	CCLE	ADSSS	DEG_SPOP_SBC_1	183:187	Mutation altering degron motif	0.7341
p.S187I	LS-411N	large intestine	COSMIC	ADSSS	DEG_SPOP_SBC_1	183:187	Mutation altering degron motif	0.7341
p.S176P	SIDM00333	Endometrial Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.1389
p.S176P	ACH-000988	Endometrial/Uterine Cancer	CCLE	ADSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.1389
p.S176P	MFE-319	endometrium	COSMIC	ADSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.1389
p.S186F	ACH-000193	Myeloma	CCLE	ADSSS	DEG_SPOP_SBC_1	183:187	Mutation altering degron motif	0.7982
p.S186F	KARPAS-620	haematopoietic and lymphoid tissue	COSMIC	ADSSS	DEG_SPOP_SBC_1	183:187	Mutation altering degron motif	0.7982
p.S184I	LS-411N	large intestine	COSMIC	ADSSS	DEG_SPOP_SBC_1	183:187	Mutation altering degron motif	0.7341
p.V275E	U251	central nervous system	COSMIC	PPSTT	DEG_SPOP_SBC_1	262:266	Mutation rewiring degron network	0.0833
p.S173P	MFE-319	endometrium	COSMIC	ADSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.0556
p.S183F	KARPAS-620	haematopoietic and lymphoid tissue	COSMIC	ADSSS	DEG_SPOP_SBC_1	183:187	Mutation altering degron motif	0.7982

Kaplan plot for ATF6B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ATF6B

UniProt ID: Q99941

Entrez ID: 1388

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ATF6B in