DegronMD

Uniprot ID: Q99941

Source protein: Cyclic AMP-dependent transcription factor ATF-6 beta

Source gene: ATF6B

Class: DEG_SPOP_SBC_1

Location: 94:98

E3 ligase: SPOP

DEGRON score: 0.9963

ASA_SCORE: 70.16

COIL: 0.8894

CONS_SCORE: 0.5547

DSS_SCORE: 0.585

HELIX: 0.0816

FCONS_SCORE: 1.1839

RIG_SCORE: 0.5664

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S99F	TCGA-DK-A3X1	BLCA	TCGA	PCSSS	DEG_SPOP_SBC_1	0.3056
p.S89Y	TCGA-EO-A22R	UCEC	TCGA	PCSSS	DEG_SPOP_SBC_1	0.6389
p.S105L	TCGA-SJ-A6ZI	UCEC	TCGA	PCSSS	DEG_SPOP_SBC_1	0.1389
p.S96F	DO447	BLCA	ICGC	PCSSS	DEG_SPOP_SBC_1	0.7982
p.S102L	DO219784	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.2222
p.S86Y	DO42713	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75385	Serine/threonine-protein kinase ULK1	DEG_SPOP_SBC_1	407:411	PCSSS	SPOP	0.9876	More...
Q03167	Transforming growth factor beta receptor type 3	DEG_SPOP_SBC_1	844:848	PCSSS	SPOP	0.998	More...
Q5T749	Keratinocyte proline-rich protein	DEG_SPOP_SBC_1	277:281	PCSSS	SPOP	0.9032	More...
Q6W2J9	BCL-6 corepressor	DEG_SPOP_SBC_1	1435:1439	PCSSS	SPOP	0.935	More...
Q8IYX3	Coiled-coil domain-containing protein 116	DEG_SPOP_SBC_1	403:407	PCSSS	SPOP	0.772	More...
Q8NBR6	Ubiquitin carboxyl-terminal hydrolase MINDY-2	DEG_SPOP_SBC_1	78:82	PCSSS	SPOP	0.992	More...
Q8WZ75	Roundabout homolog 4	DEG_SPOP_SBC_1	617:621	PCSSS	SPOP	0.8344	More...
Q99941	Cyclic AMP-dependent transcription factor ATF-6 beta	DEG_SPOP_SBC_1	94:98	PCSSS	SPOP	0.9963	More...
Q9NWZ8	Gem-associated protein 8	DEG_SPOP_SBC_1	87:91	PCSSS	SPOP	0.9101	More...
Q8TC76	Protein FAM110B	DEG_SPOP_SBC_1	216:220	PCSSS	SPOP	0.9592	More...
Q9BU23	Lipase maturation factor 2	DEG_SPOP_SBC_1	695:699	PCSSS	SPOP	0.9238	More...
Q9Y5P3	Retinoic acid-induced protein 2	DEG_SPOP_SBC_1	145:149	PCSSS	SPOP	0.7764	More...
Q7Z736	Pleckstrin homology domain-containing family H member 3	DEG_SPOP_SBC_1	755:759	PCSSS	SPOP	0.8988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons