DegronMD - Q9BU23(LMF2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R704Q	TCGA-2J-AAB6	PAAD	TCGA	PCSSS	DEG_SPOP_SBC_1	695:699	Mutation rewiring degron network	0.1944
p.R704Q	TCGA-AD-5900	COAD	TCGA	PCSSS	DEG_SPOP_SBC_1	695:699	Mutation rewiring degron network	0.1944
p.R704Q	SIDM00144	Non-Small Cell Lung Carcinoma	GDSC	PCSSS	DEG_SPOP_SBC_1	695:699	Mutation rewiring degron network	0.1944
p.R704Q	ACH-000463	Lung Cancer	CCLE	PCSSS	DEG_SPOP_SBC_1	695:699	Mutation rewiring degron network	0.1944
p.R704Q	NCI-H460	lung	COSMIC	PCSSS	DEG_SPOP_SBC_1	695:699	Mutation rewiring degron network	0.1944
p.Q679R	TCGA-77-A5GH	LUSC	TCGA	DSGAAS	DEG_SCF_TRCP1_1	681:686	Mutation rewiring degron network	0.2778
p.S700L	TCGA-AZ-4315	COAD	TCGA	PCSSS	DEG_SPOP_SBC_1	695:699	Mutation blocking phosphorylation signal	0.75
p.S700L	TCGA-EB-A6QY	SKCM	TCGA	PCSSS	DEG_SPOP_SBC_1	695:699	Mutation blocking phosphorylation signal	0.75
p.S700L	TCGA-EO-A3AV	UCEC	TCGA	PCSSS	DEG_SPOP_SBC_1	695:699	Mutation blocking phosphorylation signal	0.75
p.G671R	TCGA-AZ-6599	COAD	TCGA	DSGAAS	DEG_SCF_TRCP1_1	681:686	Mutation rewiring degron network	0.0556
p.G683E	TCGA-C5-A902	CESC	TCGA	DSGAAS	DEG_SCF_TRCP1_1	681:686	Mutation altering degron motif	0.7199
p.R704W	TCGA-CD-5801	STAD	TCGA	PCSSS	DEG_SPOP_SBC_1	695:699	Mutation rewiring degron network	0.1944
p.R674H	TCGA-CH-5772	PRAD	TCGA	DSGAAS	DEG_SCF_TRCP1_1	681:686	Mutation rewiring degron network	0.1389
p.R674H	ACH-000984	Endometrial/Uterine Cancer	CCLE	DSGAAS	DEG_SCF_TRCP1_1	681:686	Mutation rewiring degron network	0.1389
p.S682F	TCGA-DX-A8BP	SARC	TCGA	DSGAAS	DEG_SCF_TRCP1_1	681:686	Mutation altering degron motif	0.9093
p.S675L	DO8842	COAD	ICGC	DSGAAS	DEG_SCF_TRCP1_1	681:686	Mutation rewiring degron network	0.1667
p.S675L	DO48702	SKCM	ICGC	DSGAAS	DEG_SCF_TRCP1_1	681:686	Mutation rewiring degron network	0.1667
p.S675L	DO52412	UCEC	ICGC	DSGAAS	DEG_SCF_TRCP1_1	681:686	Mutation rewiring degron network	0.1667
p.R679Q	DO8514	COAD	ICGC	DSGAAS	DEG_SCF_TRCP1_1	681:686	Mutation rewiring degron network	0.2778
p.R679Q	DO51656	PAAD	ICGC	DSGAAS	DEG_SCF_TRCP1_1	681:686	Mutation rewiring degron network	0.2778
p.R679Q	NCI-H460	lung	COSMIC	DSGAAS	DEG_SCF_TRCP1_1	681:686	Mutation rewiring degron network	0.2778
p.R679W	DO38563	STAD	ICGC	DSGAAS	DEG_SCF_TRCP1_1	681:686	Mutation rewiring degron network	0.2778
p.R674C	SIDM01280	Esophageal Carcinoma	GDSC	DSGAAS	DEG_SCF_TRCP1_1	681:686	Mutation rewiring degron network	0.1389
p.G683R	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	DSGAAS	DEG_SCF_TRCP1_1	681:686	Mutation altering degron motif	0.7568
p.G683R	ACH-000980	Lung Cancer	CCLE	DSGAAS	DEG_SCF_TRCP1_1	681:686	Mutation altering degron motif	0.7568
p.A691T	SIDM00951	T-Lymphoblastic Leukemia	GDSC	DSGAAS	DEG_SCF_TRCP1_1	681:686	Mutation rewiring degron network	0.1944
p.A691T	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PCSSS	DEG_SPOP_SBC_1	695:699	Mutation rewiring degron network	0.2222
p.A691T	ACH-002222	Leukemia	CCLE	DSGAAS	DEG_SCF_TRCP1_1	681:686	Mutation rewiring degron network	0.1944
p.A691T	ACH-002222	Leukemia	CCLE	PCSSS	DEG_SPOP_SBC_1	695:699	Mutation rewiring degron network	0.2222
p.A691T	CTV-1	haematopoietic and lymphoid tissue	COSMIC	DSGAAS	DEG_SCF_TRCP1_1	681:686	Mutation rewiring degron network	0.1944
p.A691T	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PCSSS	DEG_SPOP_SBC_1	695:699	Mutation rewiring degron network	0.2222
p.R675S	ACH-000673	Brain Cancer	CCLE	DSGAAS	DEG_SCF_TRCP1_1	681:686	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LMF2

UniProt ID: Q9BU23

Entrez ID: 91289

Protein name: Lipase maturation factor 2 (Transmembrane protein 112B) (Transmembrane protein 153)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LMF2 in