DegronMD

Uniprot ID: Q9BU23

Source protein: Lipase maturation factor 2

Source gene: LMF2

Class: DEG_SPOP_SBC_1

Location: 695:699

E3 ligase: SPOP

DEGRON score: 0.9238

ASA_SCORE: 87.78

COIL: 0.9214

CONS_SCORE: 0.2098

DSS_SCORE: 0.7564

HELIX: 0.0714

FCONS_SCORE: 0.9061

RIG_SCORE: 0.5703

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R704Q	TCGA-2J-AAB6	PAAD	TCGA	PCSSS	DEG_SPOP_SBC_1	0.1944
p.R704Q	TCGA-AD-5900	COAD	TCGA	PCSSS	DEG_SPOP_SBC_1	0.1944
p.R704Q	SIDM00144	Non-Small Cell Lung Carcinoma	GDSC	PCSSS	DEG_SPOP_SBC_1	0.1944
p.R704Q	ACH-000463	Lung Cancer	CCLE	PCSSS	DEG_SPOP_SBC_1	0.1944
p.R704Q	NCI-H460	lung	COSMIC	PCSSS	DEG_SPOP_SBC_1	0.1944
p.S700L	TCGA-AZ-4315	COAD	TCGA	PCSSS	DEG_SPOP_SBC_1	0.75
p.S700L	TCGA-EB-A6QY	SKCM	TCGA	PCSSS	DEG_SPOP_SBC_1	0.75
p.S700L	TCGA-EO-A3AV	UCEC	TCGA	PCSSS	DEG_SPOP_SBC_1	0.75
p.R704W	TCGA-CD-5801	STAD	TCGA	PCSSS	DEG_SPOP_SBC_1	0.1944
p.A691T	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PCSSS	DEG_SPOP_SBC_1	0.2222
p.A691T	ACH-002222	Leukemia	CCLE	PCSSS	DEG_SPOP_SBC_1	0.2222
p.A691T	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	PCSSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75385	Serine/threonine-protein kinase ULK1	DEG_SPOP_SBC_1	407:411	PCSSS	SPOP	0.9876	More...
Q03167	Transforming growth factor beta receptor type 3	DEG_SPOP_SBC_1	844:848	PCSSS	SPOP	0.998	More...
Q5T749	Keratinocyte proline-rich protein	DEG_SPOP_SBC_1	277:281	PCSSS	SPOP	0.9032	More...
Q6W2J9	BCL-6 corepressor	DEG_SPOP_SBC_1	1435:1439	PCSSS	SPOP	0.935	More...
Q8IYX3	Coiled-coil domain-containing protein 116	DEG_SPOP_SBC_1	403:407	PCSSS	SPOP	0.772	More...
Q8NBR6	Ubiquitin carboxyl-terminal hydrolase MINDY-2	DEG_SPOP_SBC_1	78:82	PCSSS	SPOP	0.992	More...
Q8WZ75	Roundabout homolog 4	DEG_SPOP_SBC_1	617:621	PCSSS	SPOP	0.8344	More...
Q99941	Cyclic AMP-dependent transcription factor ATF-6 beta	DEG_SPOP_SBC_1	94:98	PCSSS	SPOP	0.9963	More...
Q9NWZ8	Gem-associated protein 8	DEG_SPOP_SBC_1	87:91	PCSSS	SPOP	0.9101	More...
Q8TC76	Protein FAM110B	DEG_SPOP_SBC_1	216:220	PCSSS	SPOP	0.9592	More...
Q9BU23	Lipase maturation factor 2	DEG_SPOP_SBC_1	695:699	PCSSS	SPOP	0.9238	More...
Q9Y5P3	Retinoic acid-induced protein 2	DEG_SPOP_SBC_1	145:149	PCSSS	SPOP	0.7764	More...
Q7Z736	Pleckstrin homology domain-containing family H member 3	DEG_SPOP_SBC_1	755:759	PCSSS	SPOP	0.8988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons