DegronMD - Q7Z736(PLEKHH3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T769P	TCGA-19-1387	GBM	TCGA	PCSSS	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.0556
p.T769P	DO11573	GBM	ICGC	PCSSS	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.0556
p.D768H	TCGA-95-8039	LUAD	TCGA	PCSSS	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.0833
p.D768H	DO51197	LUAD	ICGC	PCSSS	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.0833
p.A748D	TCGA-AX-A06F	UCEC	TCGA	PCSSS	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.1389
p.A748D	DO41752	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.1389
p.S757C	TCGA-CG-5727	STAD	TCGA	PCSSS	DEG_SPOP_SBC_1	755:759	Mutation altering degron motif	0.7541
p.S757C	DO38511	STAD	ICGC	PCSSS	DEG_SPOP_SBC_1	755:759	Mutation altering degron motif	0.7541
p.P750T	TCGA-CJ-4903	KIRC	TCGA	PCSSS	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.1944
p.P750T	DO18819	KIRC	ICGC	PCSSS	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.1944
p.P750L	TCGA-CK-4951	COAD	TCGA	PCSSS	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.1944
p.P750L	DO10582	COAD	ICGC	PCSSS	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.1944
p.P762Q	TCGA-ER-A19E	SKCM	TCGA	PCSSS	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.25
p.P762Q	DO47542	SKCM	ICGC	PCSSS	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.25
p.A748T	TCGA-FD-A6TF	BLCA	TCGA	PCSSS	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.1389
p.A748T	DO51880	BLCA	ICGC	PCSSS	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.1389
p.D768Y	TCGA-G2-A2EO	BLCA	TCGA	PCSSS	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.0833
p.D768Y	DO456	BLCA	ICGC	PCSSS	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.0833
p.P752L	DO50499	BOCA	ICGC	PCSSS	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.25
p.Q547H	DO229010	COCA	ICGC	PRVPLPRLD	DEG_APCC_DBOX_1	552:560	Mutation rewiring degron network	0.1944
p.Q547H	DO229013	COCA	ICGC	PRVPLPRLD	DEG_APCC_DBOX_1	552:560	Mutation rewiring degron network	0.1944
p.Q547H	DO229003	COCA	ICGC	PRVPLPRLD	DEG_APCC_DBOX_1	552:560	Mutation rewiring degron network	0.1944
p.Q547H	DO229005	COCA	ICGC	PRVPLPRLD	DEG_APCC_DBOX_1	552:560	Mutation rewiring degron network	0.1944
p.R561C	DO233898	GACA	ICGC	PRVPLPRLD	DEG_APCC_DBOX_1	552:560	Mutation rewiring degron network	0.3056
p.D549H	DO15815	HNSC	ICGC	PRVPLPRLD	DEG_APCC_DBOX_1	552:560	Mutation rewiring degron network	0.25
p.P552L	DO27326	LUSC	ICGC	PRVPLPRLD	DEG_APCC_DBOX_1	552:560	Mutation altering degron motif	0.6471
p.R548L	DO232761	PBCA	ICGC	PRVPLPRLD	DEG_APCC_DBOX_1	552:560	Mutation rewiring degron network	0.2222
p.P761S	SIDM00637	B-Cell Non-Hodgkin's Lymphoma	GDSC	PCSSS	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.2778
p.S545N	SIDM00140	Melanoma	GDSC	PRVPLPRLD	DEG_APCC_DBOX_1	552:560	Mutation blocking phosphorylation signal	0.5833
p.S545N	ACH-000968	Skin Cancer	CCLE	PRVPLPRLD	DEG_APCC_DBOX_1	552:560	Mutation blocking phosphorylation signal	0.5833
p.P762A	SIDM00902	Non-Small Cell Lung Carcinoma	GDSC	PCSSS	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.25
p.R542C	ACH-000999	Colon/Colorectal Cancer	CCLE	PRVPLPRLD	DEG_APCC_DBOX_1	552:560	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PLEKHH3

UniProt ID: Q7Z736

Entrez ID: 79990

Protein name: Pleckstrin homology domain-containing family H member 3 (PH domain-containing family H member 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PLEKHH3 in