DegronMD

Uniprot ID: Q7Z736

Source protein: Pleckstrin homology domain-containing family H member 3

Source gene: PLEKHH3

Class: DEG_APCC_DBOX_1

Location: 552:560

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9403

ASA_SCORE: 69.4778

COIL: 0.5231

CONS_SCORE: 0.4606

DSS_SCORE: 0.5869

HELIX: 0.4524

FCONS_SCORE: 0.9972

RIG_SCORE: 0.6629

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q547H	DO229010	COCA	ICGC	PRVPLPRLD	DEG_APCC_DBOX_1	0.1944
p.Q547H	DO229013	COCA	ICGC	PRVPLPRLD	DEG_APCC_DBOX_1	0.1944
p.Q547H	DO229003	COCA	ICGC	PRVPLPRLD	DEG_APCC_DBOX_1	0.1944
p.Q547H	DO229005	COCA	ICGC	PRVPLPRLD	DEG_APCC_DBOX_1	0.1944
p.R561C	DO233898	GACA	ICGC	PRVPLPRLD	DEG_APCC_DBOX_1	0.3056
p.D549H	DO15815	HNSC	ICGC	PRVPLPRLD	DEG_APCC_DBOX_1	0.25
p.P552L	DO27326	LUSC	ICGC	PRVPLPRLD	DEG_APCC_DBOX_1	0.6471
p.R548L	DO232761	PBCA	ICGC	PRVPLPRLD	DEG_APCC_DBOX_1	0.2222
p.S545N	SIDM00140	Melanoma	GDSC	PRVPLPRLD	DEG_APCC_DBOX_1	0.5833
p.S545N	ACH-000968	Skin Cancer	CCLE	PRVPLPRLD	DEG_APCC_DBOX_1	0.5833
p.R542C	ACH-000999	Colon/Colorectal Cancer	CCLE	PRVPLPRLD	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z736	Pleckstrin homology domain-containing family H member 3	DEG_APCC_DBOX_1	552:560	PRVPLPRLD	APC,CDC20,FZR1	0.9403	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons