DegronMD

Uniprot ID: Q9BU23

Source protein: Lipase maturation factor 2

Source gene: LMF2

Class: DEG_SCF_TRCP1_1

Location: 681:686

E3 ligase: BTRC

DEGRON score: 0.9867

ASA_SCORE: 73.7

COIL: 0.6612

CONS_SCORE: 0.2342

DSS_SCORE: 0.7332

HELIX: 0.3205

FCONS_SCORE: 1.0583

RIG_SCORE: 0.5614

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q679R	TCGA-77-A5GH	LUSC	TCGA	DSGAAS	DEG_SCF_TRCP1_1	0.2778
p.G671R	TCGA-AZ-6599	COAD	TCGA	DSGAAS	DEG_SCF_TRCP1_1	0.0556
p.G683E	TCGA-C5-A902	CESC	TCGA	DSGAAS	DEG_SCF_TRCP1_1	0.7199
p.R674H	TCGA-CH-5772	PRAD	TCGA	DSGAAS	DEG_SCF_TRCP1_1	0.1389
p.R674H	ACH-000984	Endometrial/Uterine Cancer	CCLE	DSGAAS	DEG_SCF_TRCP1_1	0.1389
p.S682F	TCGA-DX-A8BP	SARC	TCGA	DSGAAS	DEG_SCF_TRCP1_1	0.9093
p.S675L	DO8842	COAD	ICGC	DSGAAS	DEG_SCF_TRCP1_1	0.1667
p.S675L	DO48702	SKCM	ICGC	DSGAAS	DEG_SCF_TRCP1_1	0.1667
p.S675L	DO52412	UCEC	ICGC	DSGAAS	DEG_SCF_TRCP1_1	0.1667
p.R679Q	DO8514	COAD	ICGC	DSGAAS	DEG_SCF_TRCP1_1	0.2778
p.R679Q	DO51656	PAAD	ICGC	DSGAAS	DEG_SCF_TRCP1_1	0.2778
p.R679Q	NCI-H460	lung	COSMIC	DSGAAS	DEG_SCF_TRCP1_1	0.2778
p.R679W	DO38563	STAD	ICGC	DSGAAS	DEG_SCF_TRCP1_1	0.2778
p.R674C	SIDM01280	Esophageal Carcinoma	GDSC	DSGAAS	DEG_SCF_TRCP1_1	0.1389
p.G683R	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	DSGAAS	DEG_SCF_TRCP1_1	0.7568
p.G683R	ACH-000980	Lung Cancer	CCLE	DSGAAS	DEG_SCF_TRCP1_1	0.7568
p.A691T	SIDM00951	T-Lymphoblastic Leukemia	GDSC	DSGAAS	DEG_SCF_TRCP1_1	0.1944
p.A691T	ACH-002222	Leukemia	CCLE	DSGAAS	DEG_SCF_TRCP1_1	0.1944
p.A691T	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	DSGAAS	DEG_SCF_TRCP1_1	0.1944
p.R675S	ACH-000673	Brain Cancer	CCLE	DSGAAS	DEG_SCF_TRCP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BU23	Lipase maturation factor 2	DEG_SCF_TRCP1_1	681:686	DSGAAS	BTRC	0.9867	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons