DegronMD

Uniprot ID: Q99941

Source protein: Cyclic AMP-dependent transcription factor ATF-6 beta

Source gene: ATF6B

Class: LIG_APCC_ABBA_1

Location: 79:84

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9906

ASA_SCORE: 62.1333

COIL: 0.8422

CONS_SCORE: 0.4443

DSS_SCORE: 0.5244

HELIX: 0.1127

FCONS_SCORE: 0.9294

RIG_SCORE: 0.8098

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S89Y	TCGA-EO-A22R	UCEC	TCGA	LPIFPD	LIG_APCC_ABBA_1	0.6389
p.D81N	DO229177	LMS	ICGC	LPIFPD	LIG_APCC_ABBA_1	0.6932
p.E70G	DO46591	OV	ICGC	LPIFPD	LIG_APCC_ABBA_1	0.0833
p.S86Y	DO42713	UCEC	ICGC	LPIFPD	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99941	Cyclic AMP-dependent transcription factor ATF-6 beta	LIG_APCC_ABBA_1	79:84	LPIFPD	APC,CDC20,FZR1	0.9906	More...
Q9NQ33	Achaete-scute homolog 3	LIG_APCC_ABBA_1	13:18	LPIFPD	APC,CDC20,FZR1	0.9971	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons