DegronMD - Q9NQ33(ASCL3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P92T	TCGA-05-4382	LUAD	TCGA	NYRGCEYSYGP	CBL_PTK	81:91	Mutation rewiring degron network	0.3056
p.P92T	TCGA-85-6561	LUSC	TCGA	NYRGCEYSYGP	CBL_PTK	81:91	Mutation rewiring degron network	0.3056
p.P92T	DO24900	LUAD	ICGC	NYRGCEYSYGP	CBL_PTK	81:91	Mutation rewiring degron network	0.3056
p.P92T	DO26518	LUSC	ICGC	NYRGCEYSYGP	CBL_PTK	81:91	Mutation rewiring degron network	0.3056
p.G85V	TCGA-A4-7583	KIRP	TCGA	NYRGCEYSYGP	CBL_PTK	81:91	Mutation altering degron motif	0.7532
p.G85V	DO20870	KIRP	ICGC	NYRGCEYSYGP	CBL_PTK	81:91	Mutation altering degron motif	0.7532
p.C72Y	TCGA-CR-7392	HNSC	TCGA	NYRGCEYSYGP	CBL_PTK	81:91	Mutation rewiring degron network	0.0833
p.C72Y	DO15438	HNSC	ICGC	NYRGCEYSYGP	CBL_PTK	81:91	Mutation rewiring degron network	0.0833
p.R96L	TCGA-D3-A2JL	SKCM	TCGA	NYRGCEYSYGP	CBL_PTK	81:91	Mutation substituting flanking lysine	0.3056
p.R96L	DO47278	SKCM	ICGC	NYRGCEYSYGP	CBL_PTK	81:91	Mutation substituting flanking lysine	0.3056
p.C86Y	TCGA-D5-6530	COAD	TCGA	NYRGCEYSYGP	CBL_PTK	81:91	Mutation altering degron motif	0.7087
p.C86Y	DO8312	COAD	ICGC	NYRGCEYSYGP	CBL_PTK	81:91	Mutation altering degron motif	0.7087
p.R5K	TCGA-DK-A3WW	BLCA	TCGA	LPIFPD	LIG_APCC_ABBA_1	13:18	Mutation rewiring degron network	0.1111
p.R5K	TCGA-DK-A3WW	BLCA	TCGA	KLPIFPD	LIG_APCC_ABBAyCdc20_2	12:18	Mutation rewiring degron network	0.1389
p.R5K	DO481	BLCA	ICGC	LPIFPD	LIG_APCC_ABBA_1	13:18	Mutation rewiring degron network	0.1111
p.R5K	DO481	BLCA	ICGC	KLPIFPD	LIG_APCC_ABBAyCdc20_2	12:18	Mutation rewiring degron network	0.1389
p.R101Q	TCGA-EB-A5UM	SKCM	TCGA	NYRGCEYSYGP	CBL_PTK	81:91	Mutation rewiring degron network	0.0556
p.R101Q	DO47282	SKCM	ICGC	NYRGCEYSYGP	CBL_PTK	81:91	Mutation rewiring degron network	0.0556
p.R22S	TCGA-EY-A4KR	UCEC	TCGA	LPIFPD	LIG_APCC_ABBA_1	13:18	Mutation rewiring degron network	0.2222
p.R22S	TCGA-EY-A4KR	UCEC	TCGA	KLPIFPD	LIG_APCC_ABBAyCdc20_2	12:18	Mutation rewiring degron network	0.2222
p.R22S	DO48179	UCEC	ICGC	LPIFPD	LIG_APCC_ABBA_1	13:18	Mutation rewiring degron network	0.2222
p.R22S	DO48179	UCEC	ICGC	KLPIFPD	LIG_APCC_ABBAyCdc20_2	12:18	Mutation rewiring degron network	0.2222
p.P18S	TCGA-VQ-A8P2	STAD	TCGA	LPIFPD	LIG_APCC_ABBA_1	13:18	Mutation altering degron motif	0.6752
p.P18S	TCGA-VQ-A8P2	STAD	TCGA	KLPIFPD	LIG_APCC_ABBAyCdc20_2	12:18	Mutation altering degron motif	0.6752
p.P18S	DO51761	STAD	ICGC	LPIFPD	LIG_APCC_ABBA_1	13:18	Mutation altering degron motif	0.6752
p.P18S	DO51761	STAD	ICGC	KLPIFPD	LIG_APCC_ABBAyCdc20_2	12:18	Mutation altering degron motif	0.6752
p.E87G	DO912	BOCA	ICGC	NYRGCEYSYGP	CBL_PTK	81:91	Mutation altering degron motif	0.7199
p.R5T	DO896	BOCA	ICGC	LPIFPD	LIG_APCC_ABBA_1	13:18	Mutation rewiring degron network	0.1111
p.R5T	DO896	BOCA	ICGC	KLPIFPD	LIG_APCC_ABBAyCdc20_2	12:18	Mutation rewiring degron network	0.1389
p.R96W	DO222960	BTCA	ICGC	NYRGCEYSYGP	CBL_PTK	81:91	Mutation substituting flanking lysine	0.3056
p.T95N	DO233262	GACA	ICGC	NYRGCEYSYGP	CBL_PTK	81:91	Mutation rewiring degron network	0.2222
p.G85R	DO50756	LICA	ICGC	NYRGCEYSYGP	CBL_PTK	81:91	Mutation altering degron motif	0.7568
p.P81T	DO48720	LIRI	ICGC	NYRGCEYSYGP	CBL_PTK	81:91	Mutation altering degron motif	0.7031
p.P81L	DO220899	MELA	ICGC	NYRGCEYSYGP	CBL_PTK	81:91	Mutation altering degron motif	0.7582
p.F76S	DO232849	NACA	ICGC	NYRGCEYSYGP	CBL_PTK	81:91	Mutation rewiring degron network	0.1944
p.M2I	DO229453	SKCA	ICGC	KLPIFPD	LIG_APCC_ABBAyCdc20_2	12:18	Mutation rewiring degron network	0.0556
p.R22H	SIDM00773	Non-Cancerous	GDSC	LPIFPD	LIG_APCC_ABBA_1	13:18	Mutation rewiring degron network	0.2222
p.R22H	SIDM00773	Non-Cancerous	GDSC	KLPIFPD	LIG_APCC_ABBAyCdc20_2	12:18	Mutation rewiring degron network	0.2222
p.R22H	SIDM01126	Small Cell Lung Carcinoma	GDSC	LPIFPD	LIG_APCC_ABBA_1	13:18	Mutation rewiring degron network	0.2222
p.R22H	SIDM01126	Small Cell Lung Carcinoma	GDSC	KLPIFPD	LIG_APCC_ABBAyCdc20_2	12:18	Mutation rewiring degron network	0.2222
p.R22H	SIDM01099	Neuroblastoma	GDSC	LPIFPD	LIG_APCC_ABBA_1	13:18	Mutation rewiring degron network	0.2222
p.R22H	SIDM01099	Neuroblastoma	GDSC	KLPIFPD	LIG_APCC_ABBAyCdc20_2	12:18	Mutation rewiring degron network	0.2222
p.R22H	SIDM00287	B-Lymphoblastic Leukemia	GDSC	LPIFPD	LIG_APCC_ABBA_1	13:18	Mutation rewiring degron network	0.2222
p.R22H	SIDM00287	B-Lymphoblastic Leukemia	GDSC	KLPIFPD	LIG_APCC_ABBAyCdc20_2	12:18	Mutation rewiring degron network	0.2222
p.R22H	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	LPIFPD	LIG_APCC_ABBA_1	13:18	Mutation rewiring degron network	0.2222
p.R22H	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	KLPIFPD	LIG_APCC_ABBAyCdc20_2	12:18	Mutation rewiring degron network	0.2222
p.R22H	SIDM00429	B-Lymphoblastic Leukemia	GDSC	LPIFPD	LIG_APCC_ABBA_1	13:18	Mutation rewiring degron network	0.2222
p.R22H	SIDM00429	B-Lymphoblastic Leukemia	GDSC	KLPIFPD	LIG_APCC_ABBAyCdc20_2	12:18	Mutation rewiring degron network	0.2222
p.R22H	SIDM00721	Small Cell Lung Carcinoma	GDSC	LPIFPD	LIG_APCC_ABBA_1	13:18	Mutation rewiring degron network	0.2222
p.R22H	SIDM00721	Small Cell Lung Carcinoma	GDSC	KLPIFPD	LIG_APCC_ABBAyCdc20_2	12:18	Mutation rewiring degron network	0.2222
p.R22H	SIDM00785	Acute Myeloid Leukemia	GDSC	LPIFPD	LIG_APCC_ABBA_1	13:18	Mutation rewiring degron network	0.2222
p.R22H	SIDM00785	Acute Myeloid Leukemia	GDSC	KLPIFPD	LIG_APCC_ABBAyCdc20_2	12:18	Mutation rewiring degron network	0.2222
p.R22H	SIDM01387	Small Cell Lung Carcinoma	GDSC	LPIFPD	LIG_APCC_ABBA_1	13:18	Mutation rewiring degron network	0.2222
p.R22H	SIDM01387	Small Cell Lung Carcinoma	GDSC	KLPIFPD	LIG_APCC_ABBAyCdc20_2	12:18	Mutation rewiring degron network	0.2222
p.G91R	SIDM00747	Non-Small Cell Lung Carcinoma	GDSC	NYRGCEYSYGP	CBL_PTK	81:91	Mutation altering degron motif	0.7568
p.L10V	SIDM01757	Bladder Carcinoma	GDSC	LPIFPD	LIG_APCC_ABBA_1	13:18	Mutation rewiring degron network	0.25
p.L10V	SIDM01757	Bladder Carcinoma	GDSC	KLPIFPD	LIG_APCC_ABBAyCdc20_2	12:18	Mutation rewiring degron network	0.2778
p.L10V	ACH-000741	Bladder Cancer	CCLE	LPIFPD	LIG_APCC_ABBA_1	13:18	Mutation rewiring degron network	0.25
p.L10V	ACH-000741	Bladder Cancer	CCLE	KLPIFPD	LIG_APCC_ABBAyCdc20_2	12:18	Mutation rewiring degron network	0.2778
p.R96Q	ACH-002680	Brain Cancer	CCLE	NYRGCEYSYGP	CBL_PTK	81:91	Mutation substituting flanking lysine	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ASCL3

UniProt ID: Q9NQ33

Entrez ID: 56676

Protein name: Achaete-scute homolog 3 (ASH-3) (hASH3) (Class A basic helix-loop-helix protein 42) (bHLHa42) (bHLH transcriptional regulator Sgn-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ASCL3 in