DegronMD

Uniprot ID: Q9NQ33

Source protein: Achaete-scute homolog 3

Source gene: ASCL3

Class: LIG_APCC_ABBAyCdc20_2

Location: 12:18

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9934

ASA_SCORE: 65.8429

COIL: 0.8939

CONS_SCORE: 0.5244

DSS_SCORE: 0.384

HELIX: 0.0324

FCONS_SCORE: 0.9687

RIG_SCORE: 0.7559

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R5K	TCGA-DK-A3WW	BLCA	TCGA	KLPIFPD	LIG_APCC_ABBAyCdc20_2	0.1389
p.R5K	DO481	BLCA	ICGC	KLPIFPD	LIG_APCC_ABBAyCdc20_2	0.1389
p.R22S	TCGA-EY-A4KR	UCEC	TCGA	KLPIFPD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R22S	DO48179	UCEC	ICGC	KLPIFPD	LIG_APCC_ABBAyCdc20_2	0.2222
p.P18S	TCGA-VQ-A8P2	STAD	TCGA	KLPIFPD	LIG_APCC_ABBAyCdc20_2	0.6752
p.P18S	DO51761	STAD	ICGC	KLPIFPD	LIG_APCC_ABBAyCdc20_2	0.6752
p.R5T	DO896	BOCA	ICGC	KLPIFPD	LIG_APCC_ABBAyCdc20_2	0.1389
p.M2I	DO229453	SKCA	ICGC	KLPIFPD	LIG_APCC_ABBAyCdc20_2	0.0556
p.R22H	SIDM00773	Non-Cancerous	GDSC	KLPIFPD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R22H	SIDM01126	Small Cell Lung Carcinoma	GDSC	KLPIFPD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R22H	SIDM01099	Neuroblastoma	GDSC	KLPIFPD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R22H	SIDM00287	B-Lymphoblastic Leukemia	GDSC	KLPIFPD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R22H	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	KLPIFPD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R22H	SIDM00429	B-Lymphoblastic Leukemia	GDSC	KLPIFPD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R22H	SIDM00721	Small Cell Lung Carcinoma	GDSC	KLPIFPD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R22H	SIDM00785	Acute Myeloid Leukemia	GDSC	KLPIFPD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R22H	SIDM01387	Small Cell Lung Carcinoma	GDSC	KLPIFPD	LIG_APCC_ABBAyCdc20_2	0.2222
p.L10V	SIDM01757	Bladder Carcinoma	GDSC	KLPIFPD	LIG_APCC_ABBAyCdc20_2	0.2778
p.L10V	ACH-000741	Bladder Cancer	CCLE	KLPIFPD	LIG_APCC_ABBAyCdc20_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQ33	Achaete-scute homolog 3	LIG_APCC_ABBAyCdc20_2	12:18	KLPIFPD	APC,CDC20,FZR1	0.9934	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons