DegronMD

Uniprot ID: Q9NQ33

Source protein: Achaete-scute homolog 3

Source gene: ASCL3

Class: CBL_PTK

Location: 81:91

E3 ligase: CBL

DEGRON score: 0.7809

ASA_SCORE: 79.8091

COIL: 0.8694

CONS_SCORE: 0.5553

DSS_SCORE: 0.2328

HELIX: 0.058

FCONS_SCORE: 0.9093

RIG_SCORE: 0.7623

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P92T	TCGA-05-4382	LUAD	TCGA	NYRGCEYSYGP	CBL_PTK	0.3056
p.P92T	TCGA-85-6561	LUSC	TCGA	NYRGCEYSYGP	CBL_PTK	0.3056
p.P92T	DO24900	LUAD	ICGC	NYRGCEYSYGP	CBL_PTK	0.3056
p.P92T	DO26518	LUSC	ICGC	NYRGCEYSYGP	CBL_PTK	0.3056
p.G85V	TCGA-A4-7583	KIRP	TCGA	NYRGCEYSYGP	CBL_PTK	0.7532
p.G85V	DO20870	KIRP	ICGC	NYRGCEYSYGP	CBL_PTK	0.7532
p.C72Y	TCGA-CR-7392	HNSC	TCGA	NYRGCEYSYGP	CBL_PTK	0.0833
p.C72Y	DO15438	HNSC	ICGC	NYRGCEYSYGP	CBL_PTK	0.0833
p.R96L	TCGA-D3-A2JL	SKCM	TCGA	NYRGCEYSYGP	CBL_PTK	0.3056
p.R96L	DO47278	SKCM	ICGC	NYRGCEYSYGP	CBL_PTK	0.3056
p.C86Y	TCGA-D5-6530	COAD	TCGA	NYRGCEYSYGP	CBL_PTK	0.7087
p.C86Y	DO8312	COAD	ICGC	NYRGCEYSYGP	CBL_PTK	0.7087
p.R101Q	TCGA-EB-A5UM	SKCM	TCGA	NYRGCEYSYGP	CBL_PTK	0.0556
p.R101Q	DO47282	SKCM	ICGC	NYRGCEYSYGP	CBL_PTK	0.0556
p.E87G	DO912	BOCA	ICGC	NYRGCEYSYGP	CBL_PTK	0.7199
p.R96W	DO222960	BTCA	ICGC	NYRGCEYSYGP	CBL_PTK	0.3056
p.T95N	DO233262	GACA	ICGC	NYRGCEYSYGP	CBL_PTK	0.2222
p.G85R	DO50756	LICA	ICGC	NYRGCEYSYGP	CBL_PTK	0.7568
p.P81T	DO48720	LIRI	ICGC	NYRGCEYSYGP	CBL_PTK	0.7031
p.P81L	DO220899	MELA	ICGC	NYRGCEYSYGP	CBL_PTK	0.7582
p.F76S	DO232849	NACA	ICGC	NYRGCEYSYGP	CBL_PTK	0.1944
p.G91R	SIDM00747	Non-Small Cell Lung Carcinoma	GDSC	NYRGCEYSYGP	CBL_PTK	0.7568
p.R96Q	ACH-002680	Brain Cancer	CCLE	NYRGCEYSYGP	CBL_PTK	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQ33	Achaete-scute homolog 3	CBL_PTK	81:91	NYRGCEYSYGP	CBL	0.7809	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons