DegronMD

Uniprot ID: Q6W2J9

Source protein: BCL-6 corepressor

Source gene: BCOR

Class: DEG_SCF_FBW7_1

Location: 933:940

E3 ligase: FBXW7

DEGRON score: 0.991

ASA_SCORE: 85.35

COIL: 0.8588

CONS_SCORE: 0.4684

DSS_SCORE: 0.5777

HELIX: 0.0505

FCONS_SCORE: 0.8543

RIG_SCORE: 0.7169

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S928I	TCGA-L9-A7SV	LUAD	TCGA	VDVTPTYT	DEG_SCF_FBW7_1	0.6389
p.S928I	DO49875	LUAD	ICGC	VDVTPTYT	DEG_SCF_FBW7_1	0.6389
p.F924C	DO234458	BPLL	ICGC	VDVTPTYT	DEG_SCF_FBW7_1	0.0833
p.T936N	SIDM00934	Pancreatic Carcinoma	GDSC	VDVTPTYT	DEG_SCF_FBW7_1	0.8166
p.T936N	CAPAN-1	pancreas	COSMIC	VDVTPTYT	DEG_SCF_FBW7_1	0.8166
p.E946K	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	VDVTPTYT	DEG_SCF_FBW7_1	0.1667
p.E946K	ACH-002253	Lymphoma	CCLE	VDVTPTYT	DEG_SCF_FBW7_1	0.1667
p.E946K	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	VDVTPTYT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6W2J9	BCL-6 corepressor	DEG_SCF_FBW7_1	933:940	VDVTPTYT	FBXW7	0.991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons