DegronMD

Uniprot ID: Q6W2J9

Source protein: BCL-6 corepressor

Source gene: BCOR

Class: DEG_APCC_KENBOX_2

Location: 1324:1328

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8884

ASA_SCORE: 101.7

COIL: 0.4978

CONS_SCORE: 0.7082

DSS_SCORE: 0.5445

HELIX: 0.429

FCONS_SCORE: 1.2294

RIG_SCORE: 0.6871

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K1329R	TCGA-D1-A103	UCEC	TCGA	IKENQ	DEG_APCC_KENBOX_2	0.75
p.K1329R	DO42312	UCEC	ICGC	IKENQ	DEG_APCC_KENBOX_2	0.75
p.K1325R	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	IKENQ	DEG_APCC_KENBOX_2	0.7237
p.S1320G	DO42033	UCEC	ICGC	IKENQ	DEG_APCC_KENBOX_2	0.3333
p.Y1316F	DO44886	LIHC	ICGC	IKENQ	DEG_APCC_KENBOX_2	0.1111
p.R1316M	SIDM00007	Other Solid Cancers	GDSC	IKENQ	DEG_APCC_KENBOX_2	0.1111
p.S1315Y	TCGA-B5-A3FA	UCEC	TCGA	IKENQ	DEG_APCC_KENBOX_2	0.0833
p.S1315Y	DO52402	UCEC	ICGC	IKENQ	DEG_APCC_KENBOX_2	0.0833
p.E1337K	TCGA-YY-A8LH	PAAD	TCGA	IKENQ	DEG_APCC_KENBOX_2	0.0833

Showing 1 to 9 of 9 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6W2J9	BCL-6 corepressor	DEG_APCC_KENBOX_2	1324:1328	IKENQ	APC,CDC20,FZR1	0.8884	More...
Q13427	Peptidyl-prolyl cis-trans isomerase G	DEG_APCC_KENBOX_2	391:395	IKENQ	APC,CDC20,FZR1	0.949	More...
Q9NYU1	UDP-glucose:glycoprotein glucosyltransferase 2	DEG_APCC_KENBOX_2	359:363	IKENQ	APC,CDC20,FZR1	0.7104	More...

Showing 1 to 3 of 3 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons