DegronMD

Uniprot ID: Q13427

Source protein: Peptidyl-prolyl cis-trans isomerase G

Source gene: PPIG

Class: DEG_APCC_KENBOX_2

Location: 391:395

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.949

ASA_SCORE: 108.32

COIL: 0.4708

CONS_SCORE: 0.3456

DSS_SCORE: 0.5851

HELIX: 0.5302

FCONS_SCORE: 1.0151

RIG_SCORE: 0.7012

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L388V	TCGA-AX-A05Z	UCEC	TCGA	IKENQ	DEG_APCC_KENBOX_2	0.25
p.L388V	DO40884	UCEC	ICGC	IKENQ	DEG_APCC_KENBOX_2	0.25
p.E403Q	DO1071	BRCA	ICGC	IKENQ	DEG_APCC_KENBOX_2	0.1111
p.R400I	DO229221	THCA	ICGC	IKENQ	DEG_APCC_KENBOX_2	0.1944
p.R389K	DO229248	THCA	ICGC	IKENQ	DEG_APCC_KENBOX_2	0.2778
p.V401I	SIDM01106	Melanoma	GDSC	IKENQ	DEG_APCC_KENBOX_2	0.1667
p.V401I	ACH-000822	Skin Cancer	CCLE	IKENQ	DEG_APCC_KENBOX_2	0.1667
p.V401I	SK-MEL-24	skin	COSMIC	IKENQ	DEG_APCC_KENBOX_2	0.1667
p.V386I	SK-MEL-24	skin	COSMIC	IKENQ	DEG_APCC_KENBOX_2	0.6389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13427	Peptidyl-prolyl cis-trans isomerase G	DEG_APCC_KENBOX_2	391:395	IKENQ	APC,CDC20,FZR1	0.949	More...
Q6W2J9	BCL-6 corepressor	DEG_APCC_KENBOX_2	1324:1328	IKENQ	APC,CDC20,FZR1	0.8884	More...
Q9NYU1	UDP-glucose:glycoprotein glucosyltransferase 2	DEG_APCC_KENBOX_2	359:363	IKENQ	APC,CDC20,FZR1	0.7104	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons