DegronMD

Uniprot ID: Q9NYU1

Source protein: UDP-glucose:glycoprotein glucosyltransferase 2

Source gene: UGGT2

Class: DEG_APCC_KENBOX_2

Location: 359:363

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7104

ASA_SCORE: 76.16

COIL: 0.0564

CONS_SCORE: 0.4068

DSS_SCORE: 0.353

HELIX: 0.9452

FCONS_SCORE: 1.2521

RIG_SCORE: 0.7841

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A350T	TCGA-A5-A0VQ	UCEC	TCGA	IKENQ	DEG_APCC_KENBOX_2	0.0833
p.A350T	DO42113	UCEC	ICGC	IKENQ	DEG_APCC_KENBOX_2	0.0833
p.M355T	TCGA-A8-A09Z	BRCA	TCGA	IKENQ	DEG_APCC_KENBOX_2	0.2222
p.M355T	DO5521	BRCA	ICGC	IKENQ	DEG_APCC_KENBOX_2	0.2222
p.R356I	TCGA-AG-A002	READ	TCGA	IKENQ	DEG_APCC_KENBOX_2	0.25
p.L363F	DO48534	BLCA	ICGC	IKENQ	DEG_APCC_KENBOX_2	0.6981
p.S365T	DO227945	BRCA	ICGC	IKENQ	DEG_APCC_KENBOX_2	0.2778
p.I372T	DO222637	BTCA	ICGC	IKENQ	DEG_APCC_KENBOX_2	0.0833
p.R366C	DO50362	ESAD	ICGC	IKENQ	DEG_APCC_KENBOX_2	0.25
p.R366H	DO229051	LICA	ICGC	IKENQ	DEG_APCC_KENBOX_2	0.25
p.Q355L	DO26433	LUSC	ICGC	IKENQ	DEG_APCC_KENBOX_2	0.2222
p.I351L	DO232761	PBCA	ICGC	IKENQ	DEG_APCC_KENBOX_2	0.1111
p.N352H	SIDM01582	Gastric Carcinoma	GDSC	IKENQ	DEG_APCC_KENBOX_2	0.1389
p.N352H	ACH-000507	Gastric Cancer	CCLE	IKENQ	DEG_APCC_KENBOX_2	0.1389
p.H354N	ACH-001059	Rhabdoid	CCLE	IKENQ	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13427	Peptidyl-prolyl cis-trans isomerase G	DEG_APCC_KENBOX_2	391:395	IKENQ	APC,CDC20,FZR1	0.949	More...
Q6W2J9	BCL-6 corepressor	DEG_APCC_KENBOX_2	1324:1328	IKENQ	APC,CDC20,FZR1	0.8884	More...
Q9NYU1	UDP-glucose:glycoprotein glucosyltransferase 2	DEG_APCC_KENBOX_2	359:363	IKENQ	APC,CDC20,FZR1	0.7104	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons