DegronMD - Q13427(PPIG)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S651C	TCGA-62-8394	LUAD	TCGA	RKENS	DEG_APCC_KENBOX_2	654:658	Mutation rewiring degron network	0.25
p.S651C	DO45382	LUAD	ICGC	RKENS	DEG_APCC_KENBOX_2	654:658	Mutation rewiring degron network	0.25
p.E659K	TCGA-A2-A04Q	BRCA	TCGA	RKENS	DEG_APCC_KENBOX_2	654:658	Mutation rewiring degron network	0.3056
p.E659K	DO1678	BRCA	ICGC	RKENS	DEG_APCC_KENBOX_2	654:658	Mutation rewiring degron network	0.3056
p.S651I	TCGA-A5-A0G2	UCEC	TCGA	RKENS	DEG_APCC_KENBOX_2	654:658	Mutation rewiring degron network	0.25
p.S651I	DO41235	UCEC	ICGC	RKENS	DEG_APCC_KENBOX_2	654:658	Mutation rewiring degron network	0.25
p.Y644N	TCGA-AB-2834	LAML	TCGA	RKENS	DEG_APCC_KENBOX_2	654:658	Mutation rewiring degron network	0.0556
p.Y644N	DO21749	LAML	ICGC	RKENS	DEG_APCC_KENBOX_2	654:658	Mutation rewiring degron network	0.0556
p.L388V	TCGA-AX-A05Z	UCEC	TCGA	IKENQ	DEG_APCC_KENBOX_2	391:395	Mutation rewiring degron network	0.25
p.L388V	DO40884	UCEC	ICGC	IKENQ	DEG_APCC_KENBOX_2	391:395	Mutation rewiring degron network	0.25
p.K650N	TCGA-CQ-5326	HNSC	TCGA	RKENS	DEG_APCC_KENBOX_2	654:658	Mutation substituting flanking lysine	0.3333
p.K650N	DO15286	HNSC	ICGC	RKENS	DEG_APCC_KENBOX_2	654:658	Mutation substituting flanking lysine	0.3333
p.K650R	TCGA-IB-7651	PAAD	TCGA	RKENS	DEG_APCC_KENBOX_2	654:658	Mutation substituting flanking lysine	0.3333
p.K650R	DO46657	PAAD	ICGC	RKENS	DEG_APCC_KENBOX_2	654:658	Mutation substituting flanking lysine	0.3333
p.E656Q	TCGA-XF-AAMZ	BLCA	TCGA	RKENS	DEG_APCC_KENBOX_2	654:658	Mutation altering degron motif	0.6744
p.E656Q	DO219051	BLCA	ICGC	RKENS	DEG_APCC_KENBOX_2	654:658	Mutation altering degron motif	0.6744
p.E403Q	DO1071	BRCA	ICGC	IKENQ	DEG_APCC_KENBOX_2	391:395	Mutation rewiring degron network	0.1111
p.R400I	DO229221	THCA	ICGC	IKENQ	DEG_APCC_KENBOX_2	391:395	Mutation rewiring degron network	0.1944
p.R389K	DO229248	THCA	ICGC	IKENQ	DEG_APCC_KENBOX_2	391:395	Mutation rewiring degron network	0.2778
p.S660G	SIDM00845	Burkitt's Lymphoma	GDSC	RKENS	DEG_APCC_KENBOX_2	654:658	Mutation rewiring degron network	0.2778
p.M664T	SIDM00845	Burkitt's Lymphoma	GDSC	RKENS	DEG_APCC_KENBOX_2	654:658	Mutation rewiring degron network	0.1667
p.R663T	SIDM00538	Esophageal Carcinoma	GDSC	RKENS	DEG_APCC_KENBOX_2	654:658	Mutation rewiring degron network	0.1944
p.R663T	ACH-001497	Esophageal Cancer	CCLE	RKENS	DEG_APCC_KENBOX_2	654:658	Mutation rewiring degron network	0.1944
p.R663T	ESO51	oesophagus	COSMIC	RKENS	DEG_APCC_KENBOX_2	654:658	Mutation rewiring degron network	0.1944
p.V401I	SIDM01106	Melanoma	GDSC	IKENQ	DEG_APCC_KENBOX_2	391:395	Mutation rewiring degron network	0.1667
p.V401I	ACH-000822	Skin Cancer	CCLE	IKENQ	DEG_APCC_KENBOX_2	391:395	Mutation rewiring degron network	0.1667
p.V401I	SK-MEL-24	skin	COSMIC	IKENQ	DEG_APCC_KENBOX_2	391:395	Mutation rewiring degron network	0.1667
p.S658F	SIDM00925	Non-Small Cell Lung Carcinoma	GDSC	RKENS	DEG_APCC_KENBOX_2	654:658	Mutation altering degron motif	0.6871
p.S660T	SIDM00379	Glioma	GDSC	RKENS	DEG_APCC_KENBOX_2	654:658	Mutation rewiring degron network	0.2778
p.S660T	ACH-002304	Brain Cancer	CCLE	RKENS	DEG_APCC_KENBOX_2	654:658	Mutation rewiring degron network	0.2778
p.S660T	SK-MG-1	central nervous system	COSMIC	RKENS	DEG_APCC_KENBOX_2	654:658	Mutation rewiring degron network	0.2778
p.E656K	ACH-002396	Bone Cancer	CCLE	RKENS	DEG_APCC_KENBOX_2	654:658	Mutation altering degron motif	0.7022
p.E656K	Sarc9371	bone	COSMIC	RKENS	DEG_APCC_KENBOX_2	654:658	Mutation altering degron motif	0.7022
p.R654H	ES4	bone	COSMIC	RKENS	DEG_APCC_KENBOX_2	654:658	Mutation altering degron motif	0.7133
p.V386I	SK-MEL-24	skin	COSMIC	IKENQ	DEG_APCC_KENBOX_2	391:395	Mutation blocking phosphorylation signal	0.6389
p.S645T	SK-MG-1	central nervous system	COSMIC	RKENS	DEG_APCC_KENBOX_2	654:658	Mutation rewiring degron network	0.0833
p.N657D	NALM-6	haematopoietic and lymphoid tissue	COSMIC	RKENS	DEG_APCC_KENBOX_2	654:658	Mutation altering degron motif	0.6932
p.R648T	ESO51	oesophagus	COSMIC	RKENS	DEG_APCC_KENBOX_2	654:658	Mutation rewiring degron network	0.1667

Kaplan plot for PPIG in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PPIG

UniProt ID: Q13427

Entrez ID: 9360

Protein name: Peptidyl-prolyl cis-trans isomerase G (PPIase G) (Peptidyl-prolyl isomerase G) (EC 5.2.1.8) (CASP10) (Clk-associating RS-cyclophilin) (CARS-Cyp) (CARS-cyclophilin) (SR-cyclophilin) (SR-cyp) (SRcyp) (Cyclophilin G) (Rotamase G)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PPIG in