DegronMD

Uniprot ID: Q13427

Source protein: Peptidyl-prolyl cis-trans isomerase G

Source gene: PPIG

Class: DEG_APCC_KENBOX_2

Location: 654:658

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9596

ASA_SCORE: 129.92

COIL: 0.816

CONS_SCORE: 0.3686

DSS_SCORE: 0.7135

HELIX: 0.1744

FCONS_SCORE: 0.9895

RIG_SCORE: 0.5416

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S651C	TCGA-62-8394	LUAD	TCGA	RKENS	DEG_APCC_KENBOX_2	0.25
p.S651C	DO45382	LUAD	ICGC	RKENS	DEG_APCC_KENBOX_2	0.25
p.E659K	TCGA-A2-A04Q	BRCA	TCGA	RKENS	DEG_APCC_KENBOX_2	0.3056
p.E659K	DO1678	BRCA	ICGC	RKENS	DEG_APCC_KENBOX_2	0.3056
p.S651I	TCGA-A5-A0G2	UCEC	TCGA	RKENS	DEG_APCC_KENBOX_2	0.25
p.S651I	DO41235	UCEC	ICGC	RKENS	DEG_APCC_KENBOX_2	0.25
p.Y644N	TCGA-AB-2834	LAML	TCGA	RKENS	DEG_APCC_KENBOX_2	0.0556
p.Y644N	DO21749	LAML	ICGC	RKENS	DEG_APCC_KENBOX_2	0.0556
p.K650N	TCGA-CQ-5326	HNSC	TCGA	RKENS	DEG_APCC_KENBOX_2	0.3333
p.K650N	DO15286	HNSC	ICGC	RKENS	DEG_APCC_KENBOX_2	0.3333
p.K650R	TCGA-IB-7651	PAAD	TCGA	RKENS	DEG_APCC_KENBOX_2	0.3333
p.K650R	DO46657	PAAD	ICGC	RKENS	DEG_APCC_KENBOX_2	0.3333
p.E656Q	TCGA-XF-AAMZ	BLCA	TCGA	RKENS	DEG_APCC_KENBOX_2	0.6744
p.E656Q	DO219051	BLCA	ICGC	RKENS	DEG_APCC_KENBOX_2	0.6744
p.S660G	SIDM00845	Burkitt's Lymphoma	GDSC	RKENS	DEG_APCC_KENBOX_2	0.2778
p.M664T	SIDM00845	Burkitt's Lymphoma	GDSC	RKENS	DEG_APCC_KENBOX_2	0.1667
p.R663T	SIDM00538	Esophageal Carcinoma	GDSC	RKENS	DEG_APCC_KENBOX_2	0.1944
p.R663T	ACH-001497	Esophageal Cancer	CCLE	RKENS	DEG_APCC_KENBOX_2	0.1944
p.R663T	ESO51	oesophagus	COSMIC	RKENS	DEG_APCC_KENBOX_2	0.1944
p.S658F	SIDM00925	Non-Small Cell Lung Carcinoma	GDSC	RKENS	DEG_APCC_KENBOX_2	0.6871
p.S660T	SIDM00379	Glioma	GDSC	RKENS	DEG_APCC_KENBOX_2	0.2778
p.S660T	ACH-002304	Brain Cancer	CCLE	RKENS	DEG_APCC_KENBOX_2	0.2778
p.S660T	SK-MG-1	central_nervous_system	COSMIC	RKENS	DEG_APCC_KENBOX_2	0.2778
p.E656K	ACH-002396	Bone Cancer	CCLE	RKENS	DEG_APCC_KENBOX_2	0.7022
p.E656K	Sarc9371	bone	COSMIC	RKENS	DEG_APCC_KENBOX_2	0.7022
p.R654H	ES4	bone	COSMIC	RKENS	DEG_APCC_KENBOX_2	0.7133
p.S645T	SK-MG-1	central_nervous_system	COSMIC	RKENS	DEG_APCC_KENBOX_2	0.0833
p.N657D	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	RKENS	DEG_APCC_KENBOX_2	0.6932
p.R648T	ESO51	oesophagus	COSMIC	RKENS	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13427	Peptidyl-prolyl cis-trans isomerase G	DEG_APCC_KENBOX_2	654:658	RKENS	APC,CDC20,FZR1	0.9596	More...
Q8WXI7	Mucin-16	DEG_APCC_KENBOX_2	4603:4607	RKENS	APC,CDC20,FZR1	0.8741	More...
Q9NYV4	Cyclin-dependent kinase 12	DEG_APCC_KENBOX_2	429:433	RKENS	APC,CDC20,FZR1	0.9897	More...
Q9Y6M1	Insulin-like growth factor 2 mRNA-binding protein 2	DEG_APCC_KENBOX_2	231:235	RKENS	APC,CDC20,FZR1	0.8712	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RKENS

Degron related mutations and impact score

Drug responses associated with PPIG mutations

All proteins holding degron of RKENS