DegronMD

Uniprot ID: Q9NYV4

Source protein: Cyclin-dependent kinase 12

Source gene: CDK12

Class: DEG_APCC_KENBOX_2

Location: 429:433

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9897

ASA_SCORE: 113.3

COIL: 0.8914

CONS_SCORE: 0.3056

DSS_SCORE: 0.5757

HELIX: 0.0904

FCONS_SCORE: 0.9936

RIG_SCORE: 0.6504

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V425A	TCGA-38-4628	LUAD	TCGA	RKENS	DEG_APCC_KENBOX_2	0.2222
p.V425A	DO26354	LUAD	ICGC	RKENS	DEG_APCC_KENBOX_2	0.2222
p.K438R	TCGA-50-5930	LUAD	TCGA	RKENS	DEG_APCC_KENBOX_2	0.3056
p.K438R	DO25189	LUAD	ICGC	RKENS	DEG_APCC_KENBOX_2	0.3056
p.P428R	TCGA-85-8580	LUSC	TCGA	RKENS	DEG_APCC_KENBOX_2	0.3056
p.P428R	DO45549	LUSC	ICGC	RKENS	DEG_APCC_KENBOX_2	0.3056
p.F426V	TCGA-FI-A2D5	UCEC	TCGA	RKENS	DEG_APCC_KENBOX_2	0.25
p.F426V	DO41331	UCEC	ICGC	RKENS	DEG_APCC_KENBOX_2	0.25
p.K421N	TCGA-G4-6628	COAD	TCGA	RKENS	DEG_APCC_KENBOX_2	0.5556
p.K421N	DO10132	COAD	ICGC	RKENS	DEG_APCC_KENBOX_2	0.5556
p.S423L	DO222395	MELA	ICGC	RKENS	DEG_APCC_KENBOX_2	0.6111
p.N432H	ACH-001329	Brain Cancer	CCLE	RKENS	DEG_APCC_KENBOX_2	0.7423

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13427	Peptidyl-prolyl cis-trans isomerase G	DEG_APCC_KENBOX_2	654:658	RKENS	APC,CDC20,FZR1	0.9596	More...
Q8WXI7	Mucin-16	DEG_APCC_KENBOX_2	4603:4607	RKENS	APC,CDC20,FZR1	0.8741	More...
Q9NYV4	Cyclin-dependent kinase 12	DEG_APCC_KENBOX_2	429:433	RKENS	APC,CDC20,FZR1	0.9897	More...
Q9Y6M1	Insulin-like growth factor 2 mRNA-binding protein 2	DEG_APCC_KENBOX_2	231:235	RKENS	APC,CDC20,FZR1	0.8712	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons