DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_APCC_KENBOX_2

Location: 4603:4607

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8741

ASA_SCORE: 116.58

COIL: 0.8382

CONS_SCORE: 0

DSS_SCORE: 0.6493

HELIX: 0.0418

FCONS_SCORE: 0

RIG_SCORE: 0.7024

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R4603Q	TCGA-10-0933	OV	TCGA	RKENS	DEG_APCC_KENBOX_2	0.6218
p.R4603Q	TCGA-18-3409	LUSC	TCGA	RKENS	DEG_APCC_KENBOX_2	0.6218
p.R4603Q	TCGA-EE-A2GL	SKCM	TCGA	RKENS	DEG_APCC_KENBOX_2	0.6218
p.R4603Q	TCGA-FR-A729	SKCM	TCGA	RKENS	DEG_APCC_KENBOX_2	0.6218
p.R4603Q	TCGA-J4-A67R	PRAD	TCGA	RKENS	DEG_APCC_KENBOX_2	0.6218
p.R4603Q	DO26444	LUSC	ICGC	RKENS	DEG_APCC_KENBOX_2	0.6218
p.R4603Q	DO222868	MELA	ICGC	RKENS	DEG_APCC_KENBOX_2	0.6218
p.R4603Q	DO29358	OV	ICGC	RKENS	DEG_APCC_KENBOX_2	0.6218
p.R4603Q	DO49832	PRAD	ICGC	RKENS	DEG_APCC_KENBOX_2	0.6218
p.R4603Q	DO37434	SKCM	ICGC	RKENS	DEG_APCC_KENBOX_2	0.6218
p.R4603Q	DO48618	SKCM	ICGC	RKENS	DEG_APCC_KENBOX_2	0.6218
p.R4603Q	SIDM01013	B-Cell Non-Hodgkin's Lymphoma	GDSC	RKENS	DEG_APCC_KENBOX_2	0.6218
p.R4603Q	ACH-000106	Lymphoma	CCLE	RKENS	DEG_APCC_KENBOX_2	0.6218
p.L4599M	TCGA-44-6777	LUAD	TCGA	RKENS	DEG_APCC_KENBOX_2	0.2222
p.L4599M	DO23645	LUAD	ICGC	RKENS	DEG_APCC_KENBOX_2	0.2222
p.E4617K	TCGA-5L-AAT1	BRCA	TCGA	RKENS	DEG_APCC_KENBOX_2	0.0556
p.E4617K	TCGA-A8-A093	BRCA	TCGA	RKENS	DEG_APCC_KENBOX_2	0.0556
p.E4617K	DO4161	BRCA	ICGC	RKENS	DEG_APCC_KENBOX_2	0.0556
p.E4617K	DO219594	BRCA	ICGC	RKENS	DEG_APCC_KENBOX_2	0.0556
p.S4607I	TCGA-63-6202	LUSC	TCGA	RKENS	DEG_APCC_KENBOX_2	0.623
p.S4607I	DO26560	LUSC	ICGC	RKENS	DEG_APCC_KENBOX_2	0.623
p.T4608I	TCGA-D9-A6EC	SKCM	TCGA	RKENS	DEG_APCC_KENBOX_2	0.3056
p.T4608I	DO50291	SKCM	ICGC	RKENS	DEG_APCC_KENBOX_2	0.3056
p.S4597F	TCGA-FW-A3R5	SKCM	TCGA	RKENS	DEG_APCC_KENBOX_2	0.1667
p.S4597F	TCGA-LP-A4AV	CESC	TCGA	RKENS	DEG_APCC_KENBOX_2	0.1667
p.S4597F	DO44275	CESC	ICGC	RKENS	DEG_APCC_KENBOX_2	0.1667
p.S4597F	DO37406	SKCM	ICGC	RKENS	DEG_APCC_KENBOX_2	0.1667
p.T4600I	TCGA-VQ-A8PE	STAD	TCGA	RKENS	DEG_APCC_KENBOX_2	0.25
p.T4600I	DO51769	STAD	ICGC	RKENS	DEG_APCC_KENBOX_2	0.25
p.S4607N	DO6416	CLLE	ICGC	RKENS	DEG_APCC_KENBOX_2	0.5958
p.G4602E	DO222607	ESCA	ICGC	RKENS	DEG_APCC_KENBOX_2	0.3056
p.S4598Y	DO229036	LICA	ICGC	RKENS	DEG_APCC_KENBOX_2	0.1944
p.T4600S	DO44856	LICA	ICGC	RKENS	DEG_APCC_KENBOX_2	0.25
p.E4605V	DO35558	PBCA	ICGC	RKENS	DEG_APCC_KENBOX_2	0.7693
p.N4606K	SIDM01190	Bladder Carcinoma	GDSC	RKENS	DEG_APCC_KENBOX_2	0.6918
p.T4596I	SIDM01618	B-Lymphoblastic Leukemia	GDSC	RKENS	DEG_APCC_KENBOX_2	0.1389
p.T4596I	ACH-000942	Leukemia	CCLE	RKENS	DEG_APCC_KENBOX_2	0.1389
p.N4613T	ACH-000997	Colon/Colorectal Cancer	CCLE	RKENS	DEG_APCC_KENBOX_2	0.1667
p.N4613T	ACH-001061	Colon/Colorectal Cancer	CCLE	RKENS	DEG_APCC_KENBOX_2	0.1667
p.N4613T	HCT-15	large_intestine	COSMIC	RKENS	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13427	Peptidyl-prolyl cis-trans isomerase G	DEG_APCC_KENBOX_2	654:658	RKENS	APC,CDC20,FZR1	0.9596	More...
Q8WXI7	Mucin-16	DEG_APCC_KENBOX_2	4603:4607	RKENS	APC,CDC20,FZR1	0.8741	More...
Q9NYV4	Cyclin-dependent kinase 12	DEG_APCC_KENBOX_2	429:433	RKENS	APC,CDC20,FZR1	0.9897	More...
Q9Y6M1	Insulin-like growth factor 2 mRNA-binding protein 2	DEG_APCC_KENBOX_2	231:235	RKENS	APC,CDC20,FZR1	0.8712	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RKENS

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of RKENS