DegronMD

Uniprot ID: Q9Y6M1

Source protein: Insulin-like growth factor 2 mRNA-binding protein 2

Source gene: IGF2BP2

Class: DEG_APCC_KENBOX_2

Location: 231:235

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8712

ASA_SCORE: 122.02

COIL: 0.882

CONS_SCORE: 0.4847

DSS_SCORE: 0.5817

HELIX: 0.044

FCONS_SCORE: 0.906

RIG_SCORE: 0.6808

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P241H	TCGA-AP-A051	UCEC	TCGA	RKENS	DEG_APCC_KENBOX_2	0.1667
p.P241H	DO42673	UCEC	ICGC	RKENS	DEG_APCC_KENBOX_2	0.1667
p.R226W	TCGA-DX-AB32	SARC	TCGA	RKENS	DEG_APCC_KENBOX_2	0.1944
p.R226W	TCGA-EO-A22R	UCEC	TCGA	RKENS	DEG_APCC_KENBOX_2	0.1944
p.R226W	DO220102	SARC	ICGC	RKENS	DEG_APCC_KENBOX_2	0.1944
p.R226W	DO42713	UCEC	ICGC	RKENS	DEG_APCC_KENBOX_2	0.1944
p.R226W	SNU-407	large_intestine	COSMIC	RKENS	DEG_APCC_KENBOX_2	0.1944
p.S225F	DO234370	ESAD	ICGC	RKENS	DEG_APCC_KENBOX_2	0.1667
p.R231I	DO223007	ESCA	ICGC	RKENS	DEG_APCC_KENBOX_2	0.6991
p.R232W	SIDM00214	Colorectal Carcinoma	GDSC	RKENS	DEG_APCC_KENBOX_2	0.8634
p.R232W	SNU-407	large_intestine	COSMIC	RKENS	DEG_APCC_KENBOX_2	0.8634

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13427	Peptidyl-prolyl cis-trans isomerase G	DEG_APCC_KENBOX_2	654:658	RKENS	APC,CDC20,FZR1	0.9596	More...
Q8WXI7	Mucin-16	DEG_APCC_KENBOX_2	4603:4607	RKENS	APC,CDC20,FZR1	0.8741	More...
Q9NYV4	Cyclin-dependent kinase 12	DEG_APCC_KENBOX_2	429:433	RKENS	APC,CDC20,FZR1	0.9897	More...
Q9Y6M1	Insulin-like growth factor 2 mRNA-binding protein 2	DEG_APCC_KENBOX_2	231:235	RKENS	APC,CDC20,FZR1	0.8712	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons