DegronMD - Q9NYU1(UGGT2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A350T	TCGA-A5-A0VQ	UCEC	TCGA	IKENQ	DEG_APCC_KENBOX_2	359:363	Mutation rewiring degron network	0.0833
p.A350T	DO42113	UCEC	ICGC	IKENQ	DEG_APCC_KENBOX_2	359:363	Mutation rewiring degron network	0.0833
p.M355T	TCGA-A8-A09Z	BRCA	TCGA	IKENQ	DEG_APCC_KENBOX_2	359:363	Mutation rewiring degron network	0.2222
p.M355T	DO5521	BRCA	ICGC	IKENQ	DEG_APCC_KENBOX_2	359:363	Mutation rewiring degron network	0.2222
p.F198S	TCGA-AA-3663	COAD	TCGA	VILYAE	LIG_APCC_ABBA_1	184:189	Mutation rewiring degron network	0.0833
p.F198S	DO9346	COAD	ICGC	VILYAE	LIG_APCC_ABBA_1	184:189	Mutation rewiring degron network	0.0833
p.E189K	TCGA-AA-3984	COAD	TCGA	VILYAE	LIG_APCC_ABBA_1	184:189	Mutation altering degron motif	0.7022
p.E189K	TCGA-CG-4460	STAD	TCGA	VILYAE	LIG_APCC_ABBA_1	184:189	Mutation altering degron motif	0.7022
p.E189K	DO9002	COAD	ICGC	VILYAE	LIG_APCC_ABBA_1	184:189	Mutation altering degron motif	0.7022
p.E189K	DO234223	ESAD	ICGC	VILYAE	LIG_APCC_ABBA_1	184:189	Mutation altering degron motif	0.7022
p.E189K	DO38427	STAD	ICGC	VILYAE	LIG_APCC_ABBA_1	184:189	Mutation altering degron motif	0.7022
p.R356I	TCGA-AG-A002	READ	TCGA	IKENQ	DEG_APCC_KENBOX_2	359:363	Mutation rewiring degron network	0.25
p.H199Y	TCGA-D3-A3MV	SKCM	TCGA	VILYAE	LIG_APCC_ABBA_1	184:189	Mutation rewiring degron network	0.0556
p.H199Y	DO37727	SKCM	ICGC	VILYAE	LIG_APCC_ABBA_1	184:189	Mutation rewiring degron network	0.0556
p.E179D	TCGA-DK-A6AW	BLCA	TCGA	VILYAE	LIG_APCC_ABBA_1	184:189	Mutation rewiring degron network	0.1944
p.E179D	DO48566	BLCA	ICGC	VILYAE	LIG_APCC_ABBA_1	184:189	Mutation rewiring degron network	0.1944
p.L363F	DO48534	BLCA	ICGC	IKENQ	DEG_APCC_KENBOX_2	359:363	Mutation altering degron motif	0.6981
p.S196I	DO218388	BRCA	ICGC	VILYAE	LIG_APCC_ABBA_1	184:189	Mutation rewiring degron network	0.1389
p.S365T	DO227945	BRCA	ICGC	IKENQ	DEG_APCC_KENBOX_2	359:363	Mutation rewiring degron network	0.2778
p.I372T	DO222637	BTCA	ICGC	IKENQ	DEG_APCC_KENBOX_2	359:363	Mutation rewiring degron network	0.0833
p.R366C	DO50362	ESAD	ICGC	IKENQ	DEG_APCC_KENBOX_2	359:363	Mutation rewiring degron network	0.25
p.T192N	DO228986	LICA	ICGC	VILYAE	LIG_APCC_ABBA_1	184:189	Mutation rewiring degron network	0.25
p.R366H	DO229051	LICA	ICGC	IKENQ	DEG_APCC_KENBOX_2	359:363	Mutation rewiring degron network	0.25
p.Q355L	DO26433	LUSC	ICGC	IKENQ	DEG_APCC_KENBOX_2	359:363	Mutation rewiring degron network	0.2222
p.I351L	DO232761	PBCA	ICGC	IKENQ	DEG_APCC_KENBOX_2	359:363	Mutation rewiring degron network	0.1111
p.P175H	DO229268	THCA	ICGC	VILYAE	LIG_APCC_ABBA_1	184:189	Mutation rewiring degron network	0.0833
p.P175L	SIDM00211	B-Lymphoblastic Leukemia	GDSC	VILYAE	LIG_APCC_ABBA_1	184:189	Mutation rewiring degron network	0.0833
p.L186P	SIDM00537	Colorectal Carcinoma	GDSC	VILYAE	LIG_APCC_ABBA_1	184:189	Mutation altering degron motif	0.6471
p.L186P	ACH-001345	Colon/Colorectal Cancer	CCLE	VILYAE	LIG_APCC_ABBA_1	184:189	Mutation altering degron motif	0.6471
p.L186P	GP5d	large intestine	COSMIC	VILYAE	LIG_APCC_ABBA_1	184:189	Mutation altering degron motif	0.6471
p.M190T	SIDM00118	Colorectal Carcinoma	GDSC	VILYAE	LIG_APCC_ABBA_1	184:189	Mutation rewiring degron network	0.3056
p.M190T	ACH-001081	Colon/Colorectal Cancer	CCLE	VILYAE	LIG_APCC_ABBA_1	184:189	Mutation rewiring degron network	0.3056
p.M190T	HCC2998	large intestine	COSMIC	VILYAE	LIG_APCC_ABBA_1	184:189	Mutation rewiring degron network	0.3056
p.N352H	SIDM01582	Gastric Carcinoma	GDSC	IKENQ	DEG_APCC_KENBOX_2	359:363	Mutation rewiring degron network	0.1389
p.N352H	ACH-000507	Gastric Cancer	CCLE	IKENQ	DEG_APCC_KENBOX_2	359:363	Mutation rewiring degron network	0.1389
p.H354N	ACH-001059	Rhabdoid	CCLE	IKENQ	DEG_APCC_KENBOX_2	359:363	Mutation rewiring degron network	0.1944

Kaplan plot for UGGT2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UGGT2

UniProt ID: Q9NYU1

Entrez ID: 55757

Protein name: UDP-glucose:glycoprotein glucosyltransferase 2 (UGT2) (hUGT2) (EC 2.4.1.-) (UDP--Glc:glycoprotein glucosyltransferase 2) (UDP-glucose ceramide glucosyltransferase-like 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for UGGT2 in