DegronMD

Uniprot ID: Q9NYU1

Source protein: UDP-glucose:glycoprotein glucosyltransferase 2

Source gene: UGGT2

Class: LIG_APCC_ABBA_1

Location: 184:189

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5946

ASA_SCORE: 8.95

COIL: 0.162

CONS_SCORE: 0.4433

DSS_SCORE: 0.1616

HELIX: 0.0077

FCONS_SCORE: 1.4744

RIG_SCORE: 0.9229

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F198S	TCGA-AA-3663	COAD	TCGA	VILYAE	LIG_APCC_ABBA_1	0.0833
p.F198S	DO9346	COAD	ICGC	VILYAE	LIG_APCC_ABBA_1	0.0833
p.E189K	TCGA-AA-3984	COAD	TCGA	VILYAE	LIG_APCC_ABBA_1	0.7022
p.E189K	TCGA-CG-4460	STAD	TCGA	VILYAE	LIG_APCC_ABBA_1	0.7022
p.E189K	DO9002	COAD	ICGC	VILYAE	LIG_APCC_ABBA_1	0.7022
p.E189K	DO234223	ESAD	ICGC	VILYAE	LIG_APCC_ABBA_1	0.7022
p.E189K	DO38427	STAD	ICGC	VILYAE	LIG_APCC_ABBA_1	0.7022
p.H199Y	TCGA-D3-A3MV	SKCM	TCGA	VILYAE	LIG_APCC_ABBA_1	0.0556
p.H199Y	DO37727	SKCM	ICGC	VILYAE	LIG_APCC_ABBA_1	0.0556
p.E179D	TCGA-DK-A6AW	BLCA	TCGA	VILYAE	LIG_APCC_ABBA_1	0.1944
p.E179D	DO48566	BLCA	ICGC	VILYAE	LIG_APCC_ABBA_1	0.1944
p.S196I	DO218388	BRCA	ICGC	VILYAE	LIG_APCC_ABBA_1	0.1389
p.T192N	DO228986	LICA	ICGC	VILYAE	LIG_APCC_ABBA_1	0.25
p.P175H	DO229268	THCA	ICGC	VILYAE	LIG_APCC_ABBA_1	0.0833
p.P175L	SIDM00211	B-Lymphoblastic Leukemia	GDSC	VILYAE	LIG_APCC_ABBA_1	0.0833
p.L186P	SIDM00537	Colorectal Carcinoma	GDSC	VILYAE	LIG_APCC_ABBA_1	0.6471
p.L186P	ACH-001345	Colon/Colorectal Cancer	CCLE	VILYAE	LIG_APCC_ABBA_1	0.6471
p.L186P	GP5d	large_intestine	COSMIC	VILYAE	LIG_APCC_ABBA_1	0.6471
p.M190T	SIDM00118	Colorectal Carcinoma	GDSC	VILYAE	LIG_APCC_ABBA_1	0.3056
p.M190T	ACH-001081	Colon/Colorectal Cancer	CCLE	VILYAE	LIG_APCC_ABBA_1	0.3056
p.M190T	HCC2998	large_intestine	COSMIC	VILYAE	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NYU1	UDP-glucose:glycoprotein glucosyltransferase 2	LIG_APCC_ABBA_1	184:189	VILYAE	APC,CDC20,FZR1	0.5946	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons