DegronMD

Uniprot ID: Q6W2J9

Source protein: BCL-6 corepressor

Source gene: BCOR

Class: DEG_APCC_KENBOX_2

Location: 888:892

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9768

ASA_SCORE: 108.5

COIL: 0.8498

CONS_SCORE: 0.5542

DSS_SCORE: 0.3942

HELIX: 0.1108

FCONS_SCORE: 1.1907

RIG_SCORE: 0.7484

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K889N	TCGA-BF-AAOU	SKCM	TCGA	NKENL	DEG_APCC_KENBOX_2	0.6918
p.K889N	DO219460	SKCM	ICGC	NKENL	DEG_APCC_KENBOX_2	0.6918
p.L884M	DO229045	LICA	ICGC	NKENL	DEG_APCC_KENBOX_2	0.2222
p.V878A	SIDM00321	Ovarian Carcinoma	GDSC	NKENL	DEG_APCC_KENBOX_2	0.0556
p.V878A	SIDM01004	Chronic Myelogenous Leukemia	GDSC	NKENL	DEG_APCC_KENBOX_2	0.0556
p.V878A	SIDM00167	Head and Neck Carcinoma	GDSC	NKENL	DEG_APCC_KENBOX_2	0.0556
p.V878A	TYK-nu	ovary	COSMIC	NKENL	DEG_APCC_KENBOX_2	0.0556
p.V878A	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	NKENL	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43663	Protein regulator of cytokinesis 1	DEG_APCC_KENBOX_2	545:549	NKENL	APC,CDC20,FZR1	0.9942	More...
O75113	NEDD4-binding protein 1	DEG_APCC_KENBOX_2	143:147	NKENL	APC,CDC20,FZR1	0.7075	More...
Q6W2J9	BCL-6 corepressor	DEG_APCC_KENBOX_2	888:892	NKENL	APC,CDC20,FZR1	0.9768	More...
Q8IYA6	Cytoskeleton-associated protein 2-like	DEG_APCC_KENBOX_2	184:188	NKENL	APC,CDC20,FZR1	0.8788	More...
Q96KR7	Phosphatase and actin regulator 3	DEG_APCC_KENBOX_2	362:366	NKENL	APC,CDC20,FZR1	0.9119	More...
Q9H467	CUE domain-containing protein 2	DEG_APCC_KENBOX_2	92:96	NKENL	APC,CDC20,FZR1	0.5312	More...
Q9HAW4	Claspin	DEG_APCC_KENBOX_2	88:92	NKENL	APC,CDC20,FZR1	0.9937	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons