DegronMD - O43663(PRC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G558C	TCGA-36-2544	OV	TCGA	NKENL	DEG_APCC_KENBOX_2	545:549	Mutation rewiring degron network	0.0833
p.G558C	DO27973	OV	ICGC	NKENL	DEG_APCC_KENBOX_2	545:549	Mutation rewiring degron network	0.0833
p.G558C	SIDM01111	Ewing's Sarcoma	GDSC	NKENL	DEG_APCC_KENBOX_2	545:549	Mutation rewiring degron network	0.0833
p.G558C	ACH-000087	Bone Cancer	CCLE	NKENL	DEG_APCC_KENBOX_2	545:549	Mutation rewiring degron network	0.0833
p.G558C	SK-ES-1	bone	COSMIC	NKENL	DEG_APCC_KENBOX_2	545:549	Mutation rewiring degron network	0.0833
p.A544V	TCGA-44-7671	LUAD	TCGA	NKENL	DEG_APCC_KENBOX_2	545:549	Mutation rewiring degron network	0.3056
p.A544V	DO25252	LUAD	ICGC	NKENL	DEG_APCC_KENBOX_2	545:549	Mutation rewiring degron network	0.3056
p.N154S	TCGA-AX-A2HJ	UCEC	TCGA	DIDSASVPSL	DEG_COP1_1	141:150	Mutation rewiring degron network	0.2222
p.N154S	DO42105	UCEC	ICGC	DIDSASVPSL	DEG_COP1_1	141:150	Mutation rewiring degron network	0.2222
p.F156S	TCGA-B5-A3FC	UCEC	TCGA	DIDSASVPSL	DEG_COP1_1	141:150	Mutation rewiring degron network	0.1667
p.F156S	DO41871	UCEC	ICGC	DIDSASVPSL	DEG_COP1_1	141:150	Mutation rewiring degron network	0.1667
p.L135P	TCGA-E9-A1R4	BRCA	TCGA	DIDSASVPSL	DEG_COP1_1	141:150	Mutation rewiring degron network	0.1667
p.L135P	DO5815	BRCA	ICGC	DIDSASVPSL	DEG_COP1_1	141:150	Mutation rewiring degron network	0.1667
p.E133K	TCGA-EI-6917	READ	TCGA	DIDSASVPSL	DEG_COP1_1	141:150	Mutation rewiring degron network	0.1111
p.E133K	DO36881	READ	ICGC	DIDSASVPSL	DEG_COP1_1	141:150	Mutation rewiring degron network	0.1111
p.L135I	TCGA-EO-A3B0	UCEC	TCGA	DIDSASVPSL	DEG_COP1_1	141:150	Mutation rewiring degron network	0.1667
p.L135I	DO219773	UCEC	ICGC	DIDSASVPSL	DEG_COP1_1	141:150	Mutation rewiring degron network	0.1667
p.G553S	DO230339	COCA	ICGC	NKENL	DEG_APCC_KENBOX_2	545:549	Mutation rewiring degron network	0.2222
p.E133D	DO227668	COCA	ICGC	DIDSASVPSL	DEG_COP1_1	141:150	Mutation rewiring degron network	0.1111
p.I134S	DO222884	COCA	ICGC	DIDSASVPSL	DEG_COP1_1	141:150	Mutation rewiring degron network	0.1389
p.N545D	DO234462	ESAD	ICGC	NKENL	DEG_APCC_KENBOX_2	545:549	Mutation altering degron motif	0.5821
p.N548K	DO228974	LICA	ICGC	NKENL	DEG_APCC_KENBOX_2	545:549	Mutation altering degron motif	0.6918
p.H159N	DO229029	LICA	ICGC	DIDSASVPSL	DEG_COP1_1	141:150	Mutation rewiring degron network	0.0833
p.S144T	DO230993	LUSC	ICGC	DIDSASVPSL	DEG_COP1_1	141:150	Mutation altering degron motif	0.6005
p.S144T	DO231007	LUSC	ICGC	DIDSASVPSL	DEG_COP1_1	141:150	Mutation altering degron motif	0.6005
p.M137V	SIDM00282	Colorectal Carcinoma	GDSC	DIDSASVPSL	DEG_COP1_1	141:150	Mutation rewiring degron network	0.2222
p.M137V	ACH-000998	Colon/Colorectal Cancer	CCLE	DIDSASVPSL	DEG_COP1_1	141:150	Mutation rewiring degron network	0.2222
p.M137V	CW-2	large intestine	COSMIC	DIDSASVPSL	DEG_COP1_1	141:150	Mutation rewiring degron network	0.2222
p.G559W	SIDM00841	Colorectal Carcinoma	GDSC	NKENL	DEG_APCC_KENBOX_2	545:549	Mutation rewiring degron network	0.0556
p.G559W	ACH-000651	Colon/Colorectal Cancer	CCLE	NKENL	DEG_APCC_KENBOX_2	545:549	Mutation rewiring degron network	0.0556
p.G559W	SW620	large intestine	COSMIC	NKENL	DEG_APCC_KENBOX_2	545:549	Mutation rewiring degron network	0.0556
p.R538C	SIDM00126	Melanoma	GDSC	NKENL	DEG_APCC_KENBOX_2	545:549	Mutation rewiring degron network	0.1389
p.R538C	ACH-002147	Skin Cancer	CCLE	NKENL	DEG_APCC_KENBOX_2	545:549	Mutation rewiring degron network	0.1389
p.R538C	K2	skin	COSMIC	NKENL	DEG_APCC_KENBOX_2	545:549	Mutation rewiring degron network	0.1389
p.E151Q	SIDM01757	Bladder Carcinoma	GDSC	DIDSASVPSL	DEG_COP1_1	141:150	Mutation rewiring degron network	0.3056
p.E151Q	ACH-000741	Bladder Cancer	CCLE	DIDSASVPSL	DEG_COP1_1	141:150	Mutation rewiring degron network	0.3056
p.S146L	SIDM00784	Glioma	GDSC	DIDSASVPSL	DEG_COP1_1	141:150	Mutation altering degron motif	0.6556
p.S146L	ACH-000126	Brain Cancer	CCLE	DIDSASVPSL	DEG_COP1_1	141:150	Mutation altering degron motif	0.6556
p.D152N	639-V	urinary tract	COSMIC	DIDSASVPSL	DEG_COP1_1	141:150	Mutation rewiring degron network	0.2778

Kaplan plot for PRC1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRC1

UniProt ID: O43663

Entrez ID: 9055

Protein name: Protein regulator of cytokinesis 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRC1 in