DegronMD

Uniprot ID: O43663

Source protein: Protein regulator of cytokinesis 1

Source gene: PRC1

Class: DEG_COP1_1

Location: 141:150

E3 ligase: COP1

DEGRON score: 0.5814

ASA_SCORE: 66.15

COIL: 0.8108

CONS_SCORE: 0.4399

DSS_SCORE: 0.3009

HELIX: 0.1548

FCONS_SCORE: 0.9615

RIG_SCORE: 0.7454

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N154S	TCGA-AX-A2HJ	UCEC	TCGA	DIDSASVPSL	DEG_COP1_1	0.2222
p.N154S	DO42105	UCEC	ICGC	DIDSASVPSL	DEG_COP1_1	0.2222
p.F156S	TCGA-B5-A3FC	UCEC	TCGA	DIDSASVPSL	DEG_COP1_1	0.1667
p.F156S	DO41871	UCEC	ICGC	DIDSASVPSL	DEG_COP1_1	0.1667
p.L135P	TCGA-E9-A1R4	BRCA	TCGA	DIDSASVPSL	DEG_COP1_1	0.1667
p.L135P	DO5815	BRCA	ICGC	DIDSASVPSL	DEG_COP1_1	0.1667
p.E133K	TCGA-EI-6917	READ	TCGA	DIDSASVPSL	DEG_COP1_1	0.1111
p.E133K	DO36881	READ	ICGC	DIDSASVPSL	DEG_COP1_1	0.1111
p.L135I	TCGA-EO-A3B0	UCEC	TCGA	DIDSASVPSL	DEG_COP1_1	0.1667
p.L135I	DO219773	UCEC	ICGC	DIDSASVPSL	DEG_COP1_1	0.1667
p.E133D	DO227668	COCA	ICGC	DIDSASVPSL	DEG_COP1_1	0.1111
p.I134S	DO222884	COCA	ICGC	DIDSASVPSL	DEG_COP1_1	0.1389
p.H159N	DO229029	LICA	ICGC	DIDSASVPSL	DEG_COP1_1	0.0833
p.S144T	DO230993	LUSC	ICGC	DIDSASVPSL	DEG_COP1_1	0.6005
p.S144T	DO231007	LUSC	ICGC	DIDSASVPSL	DEG_COP1_1	0.6005
p.M137V	SIDM00282	Colorectal Carcinoma	GDSC	DIDSASVPSL	DEG_COP1_1	0.2222
p.M137V	ACH-000998	Colon/Colorectal Cancer	CCLE	DIDSASVPSL	DEG_COP1_1	0.2222
p.M137V	CW-2	large_intestine	COSMIC	DIDSASVPSL	DEG_COP1_1	0.2222
p.E151Q	SIDM01757	Bladder Carcinoma	GDSC	DIDSASVPSL	DEG_COP1_1	0.3056
p.E151Q	ACH-000741	Bladder Cancer	CCLE	DIDSASVPSL	DEG_COP1_1	0.3056
p.S146L	SIDM00784	Glioma	GDSC	DIDSASVPSL	DEG_COP1_1	0.6556
p.S146L	ACH-000126	Brain Cancer	CCLE	DIDSASVPSL	DEG_COP1_1	0.6556
p.D152N	639-V	urinary_tract	COSMIC	DIDSASVPSL	DEG_COP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43663	Protein regulator of cytokinesis 1	DEG_COP1_1	141:150	DIDSASVPSL	COP1	0.5814	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons