DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
AATST
Uniprot ID:
Q9BVL2
Source protein:
Nucleoporin p58/p45
Source gene:
NUP58
Class:
DEG_SPOP_SBC_1
Location:
206:210
E3 ligase:
SPOP
DEGRON score:
0.9912
ASA_SCORE:
61.04
COIL:
0.7248
CONS_SCORE:
0.3819
DSS_SCORE:
0.391
HELIX:
0.08
FCONS_SCORE:
0.8257
RIG_SCORE:
0.7505
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with NUP58 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of AATST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O75056
Syndecan-3
DEG_SPOP_SBC_1
167:171
AATST
SPOP
0.9748
More...
P35658
Nuclear pore complex protein Nup214
DEG_SPOP_SBC_1
594:598
AATST
SPOP
0.737
More...
P35658
Nuclear pore complex protein Nup214
DEG_SPOP_SBC_1
1401:1405
AATST
SPOP
0.9715
More...
Q05209
Tyrosine-protein phosphatase non-receptor type 12
DEG_SPOP_SBC_1
633:637
AATST
SPOP
0.9815
More...
Q4KMQ1
Taperin
DEG_SPOP_SBC_1
289:293
AATST
SPOP
0.9965
More...
Q6W2J9
BCL-6 corepressor
DEG_SPOP_SBC_1
104:108
AATST
SPOP
0.9528
More...
Q86Z02
Homeodomain-interacting protein kinase 1
DEG_SPOP_SBC_1
95:99
AATST
SPOP
0.9812
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
11752:11756
AATST
SPOP
0.9954
More...
Q96BD5
PHD finger protein 21A
DEG_SPOP_SBC_1
655:659
AATST
SPOP
0.9845
More...
Q96FS4
Signal-induced proliferation-associated protein 1
DEG_SPOP_SBC_1
82:86
AATST
SPOP
0.9975
More...
Q9BVL2
Nucleoporin p58/p45
DEG_SPOP_SBC_1
206:210
AATST
SPOP
0.9912
More...
Q9NZN1
Interleukin-1 receptor accessory protein-like 1
DEG_SPOP_SBC_1
594:598
AATST
SPOP
0.6429
More...
Q9ULV3
Cip1-interacting zinc finger protein
DEG_SPOP_SBC_1
581:585
AATST
SPOP
0.9621
More...
Q9Y446
Plakophilin-3
DEG_SPOP_SBC_1
205:209
AATST
SPOP
0.9186
More...
Q9Y6Y8
SEC23-interacting protein
DEG_SPOP_SBC_1
718:722
AATST
SPOP
0.6755
More...
Q8N3X1
Formin-binding protein 4
DEG_SPOP_SBC_1
181:185
AATST
SPOP
0.7939
More...
Q86XN7
Proline and serine-rich protein 1
DEG_SPOP_SBC_1
732:736
AATST
SPOP
0.9872
More...