DegronMD

Uniprot ID: Q05209

Source protein: Tyrosine-protein phosphatase non-receptor type 12

Source gene: PTPN12

Class: DEG_SPOP_SBC_1

Location: 633:637

E3 ligase: SPOP

DEGRON score: 0.9815

ASA_SCORE: 84.38

COIL: 0.8874

CONS_SCORE: 0.5091

DSS_SCORE: 0.4513

HELIX: 0.0658

FCONS_SCORE: 0.9862

RIG_SCORE: 0.7217

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S625L	TCGA-52-7812	LUSC	TCGA	AATST	DEG_SPOP_SBC_1	0.1111
p.T642A	TCGA-EQ-5647	STAD	TCGA	AATST	DEG_SPOP_SBC_1	0.1944
p.R635Q	DO9876	COAD	ICGC	AATST	DEG_SPOP_SBC_1	0.7329
p.R635Q	DO47769	STAD	ICGC	AATST	DEG_SPOP_SBC_1	0.7329
p.D629A	DO222798	COCA	ICGC	AATST	DEG_SPOP_SBC_1	0.2222
p.P624S	DO37782	SKCM	ICGC	AATST	DEG_SPOP_SBC_1	0.0833
p.P624L	DO51276	SKCM	ICGC	AATST	DEG_SPOP_SBC_1	0.0833
p.N623H	DO43202	UCEC	ICGC	AATST	DEG_SPOP_SBC_1	0.0556
p.T635I	SIDM00011	Melanoma	GDSC	AATST	DEG_SPOP_SBC_1	0.7078
p.T635I	ACH-000477	Skin Cancer	CCLE	AATST	DEG_SPOP_SBC_1	0.7078

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75056	Syndecan-3	DEG_SPOP_SBC_1	167:171	AATST	SPOP	0.9748	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	594:598	AATST	SPOP	0.737	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1401:1405	AATST	SPOP	0.9715	More...
Q05209	Tyrosine-protein phosphatase non-receptor type 12	DEG_SPOP_SBC_1	633:637	AATST	SPOP	0.9815	More...
Q4KMQ1	Taperin	DEG_SPOP_SBC_1	289:293	AATST	SPOP	0.9965	More...
Q6W2J9	BCL-6 corepressor	DEG_SPOP_SBC_1	104:108	AATST	SPOP	0.9528	More...
Q86Z02	Homeodomain-interacting protein kinase 1	DEG_SPOP_SBC_1	95:99	AATST	SPOP	0.9812	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11752:11756	AATST	SPOP	0.9954	More...
Q96BD5	PHD finger protein 21A	DEG_SPOP_SBC_1	655:659	AATST	SPOP	0.9845	More...
Q96FS4	Signal-induced proliferation-associated protein 1	DEG_SPOP_SBC_1	82:86	AATST	SPOP	0.9975	More...
Q9BVL2	Nucleoporin p58/p45	DEG_SPOP_SBC_1	206:210	AATST	SPOP	0.9912	More...
Q9NZN1	Interleukin-1 receptor accessory protein-like 1	DEG_SPOP_SBC_1	594:598	AATST	SPOP	0.6429	More...
Q9ULV3	Cip1-interacting zinc finger protein	DEG_SPOP_SBC_1	581:585	AATST	SPOP	0.9621	More...
Q9Y446	Plakophilin-3	DEG_SPOP_SBC_1	205:209	AATST	SPOP	0.9186	More...
Q9Y6Y8	SEC23-interacting protein	DEG_SPOP_SBC_1	718:722	AATST	SPOP	0.6755	More...
Q8N3X1	Formin-binding protein 4	DEG_SPOP_SBC_1	181:185	AATST	SPOP	0.7939	More...
Q86XN7	Proline and serine-rich protein 1	DEG_SPOP_SBC_1	732:736	AATST	SPOP	0.9872	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons