DegronMD - Q9ULV3(CIZ1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F593L	TCGA-A5-A2K5	UCEC	TCGA	VSSTPAAT	DEG_SCF_FBW7_1	576:583	Mutation rewiring degron network	0.0556
p.F593L	TCGA-A5-A2K5	UCEC	TCGA	AATST	DEG_SPOP_SBC_1	581:585	Mutation rewiring degron network	0.1111
p.R571H	TCGA-AA-3877	COAD	TCGA	VSSTPAAT	DEG_SCF_FBW7_1	576:583	Mutation rewiring degron network	0.1944
p.R571H	TCGA-AA-3877	COAD	TCGA	AATST	DEG_SPOP_SBC_1	581:585	Mutation rewiring degron network	0.0556
p.R571H	TCGA-B5-A11E	UCEC	TCGA	VSSTPAAT	DEG_SCF_FBW7_1	576:583	Mutation rewiring degron network	0.1944
p.R571H	TCGA-B5-A11E	UCEC	TCGA	AATST	DEG_SPOP_SBC_1	581:585	Mutation rewiring degron network	0.0556
p.R571H	DO7855	COAD	ICGC	VSSTPAAT	DEG_SCF_FBW7_1	576:583	Mutation rewiring degron network	0.1944
p.R571H	DO7855	COAD	ICGC	AATST	DEG_SPOP_SBC_1	581:585	Mutation rewiring degron network	0.0556
p.R571H	DO41644	UCEC	ICGC	VSSTPAAT	DEG_SCF_FBW7_1	576:583	Mutation rewiring degron network	0.1944
p.R571H	DO41644	UCEC	ICGC	AATST	DEG_SPOP_SBC_1	581:585	Mutation rewiring degron network	0.0556
p.R571H	LN-405	central nervous system	COSMIC	VSSTPAAT	DEG_SCF_FBW7_1	576:583	Mutation rewiring degron network	0.1944
p.R571H	LN-405	central nervous system	COSMIC	AATST	DEG_SPOP_SBC_1	581:585	Mutation rewiring degron network	0.0556
p.R179W	TCGA-AZ-6598	COAD	TCGA	ARTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.1667
p.R179W	DO10276	COAD	ICGC	ARTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.1667
p.R186W	TCGA-CM-6162	COAD	TCGA	ARTSS	DEG_SPOP_SBC_1	185:189	Mutation altering degron motif	0.7523
p.R186W	DO8479	COAD	ICGC	ARTSS	DEG_SPOP_SBC_1	185:189	Mutation altering degron motif	0.7523
p.K196N	TCGA-D3-A2JC	SKCM	TCGA	ARTSS	DEG_SPOP_SBC_1	185:189	Mutation substituting flanking lysine	0.25
p.R865C	TCGA-DF-A2KU	UCEC	TCGA	ARNALTALF	DEG_APCC_DBOX_1	852:860	Mutation rewiring degron network	0.1944
p.R865C	TCGA-DF-A2KU	UCEC	TCGA	TQDKTPSK	DEG_SCF_SKP2-CKS1_1	872:879	Mutation rewiring degron network	0.1389
p.R865C	DO223286	UCEC	ICGC	ARNALTALF	DEG_APCC_DBOX_1	852:860	Mutation rewiring degron network	0.1944
p.R865C	DO223286	UCEC	ICGC	TQDKTPSK	DEG_SCF_SKP2-CKS1_1	872:879	Mutation rewiring degron network	0.1389
p.S177L	TCGA-DR-A0ZM	CESC	TCGA	ARTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.1111
p.P193T	TCGA-EE-A2MK	SKCM	TCGA	ARTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.2222
p.P193T	DO38177	SKCM	ICGC	ARTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.2222
p.A849T	TCGA-S8-A6BV	ESCA	TCGA	ARNALTALF	DEG_APCC_DBOX_1	852:860	Mutation rewiring degron network	0.25
p.R195Q	TCGA-SJ-A6ZI	UCEC	TCGA	ARTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.1667
p.R195Q	DO219784	UCEC	ICGC	ARTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.1667
p.R584Q	DO230342	COCA	ICGC	AATST	DEG_SPOP_SBC_1	581:585	Mutation altering degron motif	0.7329
p.G849C	DO222769	COCA	ICGC	ARNALTALF	DEG_APCC_DBOX_1	852:860	Mutation rewiring degron network	0.25
p.S198Y	DO222798	COCA	ICGC	ARTSS	DEG_SPOP_SBC_1	185:189	Mutation blocking phosphorylation signal	0.5278
p.D197N	DO50445	ESAD	ICGC	ARTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.1111
p.G469D	DO234227	ESAD	ICGC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	474:485	Mutation rewiring degron network	0.1944
p.R846C	DO233737	GACA	ICGC	ARNALTALF	DEG_APCC_DBOX_1	852:860	Mutation rewiring degron network	0.1667
p.P877H	DO233935	GACA	ICGC	TQDKTPSK	DEG_SCF_SKP2-CKS1_1	872:879	Mutation altering degron motif	0.7694
p.Q869K	DO228948	LICA	ICGC	ARNALTALF	DEG_APCC_DBOX_1	852:860	Mutation rewiring degron network	0.0833
p.Q869K	DO228948	LICA	ICGC	TQDKTPSK	DEG_SCF_SKP2-CKS1_1	872:879	Mutation rewiring degron network	0.25
p.Q869K	DO229032	LICA	ICGC	ARNALTALF	DEG_APCC_DBOX_1	852:860	Mutation rewiring degron network	0.0833
p.Q869K	DO229032	LICA	ICGC	TQDKTPSK	DEG_SCF_SKP2-CKS1_1	872:879	Mutation rewiring degron network	0.25
p.Q869K	DO229038	LICA	ICGC	ARNALTALF	DEG_APCC_DBOX_1	852:860	Mutation rewiring degron network	0.0833
p.Q869K	DO229038	LICA	ICGC	TQDKTPSK	DEG_SCF_SKP2-CKS1_1	872:879	Mutation rewiring degron network	0.25
p.A574D	DO228948	LICA	ICGC	VSSTPAAT	DEG_SCF_FBW7_1	576:583	Mutation rewiring degron network	0.2778
p.A574D	DO228948	LICA	ICGC	AATST	DEG_SPOP_SBC_1	581:585	Mutation rewiring degron network	0.1389
p.T479K	DO228952	LICA	ICGC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	474:485	Mutation altering degron motif	0.6195
p.P870T	DO228952	LICA	ICGC	ARNALTALF	DEG_APCC_DBOX_1	852:860	Mutation rewiring degron network	0.0556
p.P870T	DO228952	LICA	ICGC	TQDKTPSK	DEG_SCF_SKP2-CKS1_1	872:879	Mutation rewiring degron network	0.2778
p.P870T	DO229025	LICA	ICGC	ARNALTALF	DEG_APCC_DBOX_1	852:860	Mutation rewiring degron network	0.0556
p.P870T	DO229025	LICA	ICGC	TQDKTPSK	DEG_SCF_SKP2-CKS1_1	872:879	Mutation rewiring degron network	0.2778
p.T861I	DO228960	LICA	ICGC	ARNALTALF	DEG_APCC_DBOX_1	852:860	Mutation rewiring degron network	0.3056
p.P869S	DO228960	LICA	ICGC	ARNALTALF	DEG_APCC_DBOX_1	852:860	Mutation rewiring degron network	0.0833
p.P869S	DO228960	LICA	ICGC	TQDKTPSK	DEG_SCF_SKP2-CKS1_1	872:879	Mutation rewiring degron network	0.25
p.P867T	DO228985	LICA	ICGC	ARNALTALF	DEG_APCC_DBOX_1	852:860	Mutation rewiring degron network	0.1389
p.P867T	DO228985	LICA	ICGC	TQDKTPSK	DEG_SCF_SKP2-CKS1_1	872:879	Mutation rewiring degron network	0.1944
p.S189F	DO222880	MELA	ICGC	ARTSS	DEG_SPOP_SBC_1	185:189	Mutation altering degron motif	0.7982
p.S868P	DO218906	SKCA	ICGC	ARNALTALF	DEG_APCC_DBOX_1	852:860	Mutation blocking phosphorylation signal	0.5556
p.S868P	DO218906	SKCA	ICGC	TQDKTPSK	DEG_SCF_SKP2-CKS1_1	872:879	Mutation blocking phosphorylation signal	0.6667
p.K846R	DO222392	STAD	ICGC	ARNALTALF	DEG_APCC_DBOX_1	852:860	Mutation rewiring degron network	0.1667
p.V880G	DO229272	THCA	ICGC	TQDKTPSK	DEG_SCF_SKP2-CKS1_1	872:879	Mutation rewiring degron network	0.3056
p.A858S	DO229208	THCA	ICGC	ARNALTALF	DEG_APCC_DBOX_1	852:860	Mutation altering degron motif	0.6477
p.Q869P	DO229234	THCA	ICGC	ARNALTALF	DEG_APCC_DBOX_1	852:860	Mutation rewiring degron network	0.0833
p.Q869P	DO229234	THCA	ICGC	TQDKTPSK	DEG_SCF_SKP2-CKS1_1	872:879	Mutation rewiring degron network	0.25
p.Q873P	DO229234	THCA	ICGC	TQDKTPSK	DEG_SCF_SKP2-CKS1_1	872:879	Mutation altering degron motif	0.5924
p.T866A	DO223282	UCEC	ICGC	ARNALTALF	DEG_APCC_DBOX_1	852:860	Mutation rewiring degron network	0.1667
p.T866A	DO223282	UCEC	ICGC	TQDKTPSK	DEG_SCF_SKP2-CKS1_1	872:879	Mutation rewiring degron network	0.1667
p.R193Q	DO41871	UCEC	ICGC	ARTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.2222
p.E184D	DO42400	UCEC	ICGC	ARTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.3056
p.A581V	DO41199	UCEC	ICGC	VSSTPAAT	DEG_SCF_FBW7_1	576:583	Mutation altering degron motif	0.5825
p.A581V	DO41199	UCEC	ICGC	AATST	DEG_SPOP_SBC_1	581:585	Mutation altering degron motif	0.5825
p.A481V	SIDM00946	T-Lymphoblastic Leukemia	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	474:485	Mutation altering degron motif	0.6936
p.A481V	SIDM00582	Pancreatic Carcinoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	474:485	Mutation altering degron motif	0.6936
p.A481V	SIDM00608	Plasma Cell Myeloma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	474:485	Mutation altering degron motif	0.6936
p.A481V	SIDM00572	Gastric Carcinoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	474:485	Mutation altering degron motif	0.6936
p.A481V	SIDM01040	Ovarian Carcinoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	474:485	Mutation altering degron motif	0.6936
p.A481V	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	474:485	Mutation altering degron motif	0.6936
p.A481V	SIDM00367	Small Cell Lung Carcinoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	474:485	Mutation altering degron motif	0.6936
p.A481V	SIDM00581	Glioblastoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	474:485	Mutation altering degron motif	0.6936
p.A481V	SIDM00355	Non-Small Cell Lung Carcinoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	474:485	Mutation altering degron motif	0.6936
p.A481V	SIDM00235	Kidney Carcinoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	474:485	Mutation altering degron motif	0.6936
p.A481V	SIDM00290	Gastric Carcinoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	474:485	Mutation altering degron motif	0.6936
p.A481V	SIDM00567	Other Solid Cancers	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	474:485	Mutation altering degron motif	0.6936
p.A481V	SIDM00988	Kidney Carcinoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	474:485	Mutation altering degron motif	0.6936
p.A481V	SIDM01217	Other Blood Cancers	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	474:485	Mutation altering degron motif	0.6936
p.A481V	SIDM00324	Neuroblastoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	474:485	Mutation altering degron motif	0.6936
p.A481V	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	474:485	Mutation altering degron motif	0.6936
p.A481V	SIDM00233	T-Lymphoblastic Leukemia	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	474:485	Mutation altering degron motif	0.6936
p.A481V	SIDM00359	Colorectal Carcinoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	474:485	Mutation altering degron motif	0.6936
p.A481V	SIDM01551	Gastric Carcinoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	474:485	Mutation altering degron motif	0.6936
p.A481V	SIDM01781	Gastric Carcinoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	474:485	Mutation altering degron motif	0.6936
p.A481V	SIDM01336	Glioblastoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	474:485	Mutation altering degron motif	0.6936
p.A481V	SIDM01575	Plasma Cell Myeloma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	474:485	Mutation altering degron motif	0.6936
p.A481V	SIDM01378	Ovarian Carcinoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	474:485	Mutation altering degron motif	0.6936
p.A481V	SIDM01782	Oral Cavity Carcinoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	474:485	Mutation altering degron motif	0.6936
p.A481V	SIDM01662	Plasma Cell Myeloma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	474:485	Mutation altering degron motif	0.6936
p.M199I	SIDM01201	Other Blood Cancers	GDSC	ARTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.0556
p.M199I	NK-92MI	haematopoietic and lymphoid tissue	COSMIC	ARTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.0556
p.A889V	SIDM01155	Glioma	GDSC	TQDKTPSK	DEG_SCF_SKP2-CKS1_1	872:879	Mutation rewiring degron network	0.0556
p.P495L	SIDM01749	Osteosarcoma	GDSC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	474:485	Mutation rewiring degron network	0.0556
p.R865H	ACH-000306	Non-Cancerous	CCLE	ARNALTALF	DEG_APCC_DBOX_1	852:860	Mutation rewiring degron network	0.1944
p.R865H	ACH-000306	Non-Cancerous	CCLE	TQDKTPSK	DEG_SCF_SKP2-CKS1_1	872:879	Mutation rewiring degron network	0.1389
p.P465L	ACH-000340	Non-Cancerous	CCLE	LAPEQTPVVVHV	DEG_ODPH_VHL_1	474:485	Mutation rewiring degron network	0.0833
p.R847W	ACH-000995	Leukemia	CCLE	ARNALTALF	DEG_APCC_DBOX_1	852:860	Mutation rewiring degron network	0.1944
p.N175H	ACH-002397	Thyroid Cancer	CCLE	ARTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.0556
p.N175H	KMH-2	thyroid	COSMIC	ARTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.0556
p.Q568R	GR-ST	haematopoietic and lymphoid tissue	COSMIC	VSSTPAAT	DEG_SCF_FBW7_1	576:583	Mutation rewiring degron network	0.1111
p.E189Q	AN3-CA	endometrium	COSMIC	ARTSS	DEG_SPOP_SBC_1	185:189	Mutation altering degron motif	0.6744
p.T491A	CAL-51	breast	COSMIC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	474:485	Mutation rewiring degron network	0.1667
p.P199H	EJM	haematopoietic and lymphoid tissue	COSMIC	ARTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.0556
p.S577F	CAL-62	thyroid	COSMIC	VSSTPAAT	DEG_SCF_FBW7_1	576:583	Mutation altering degron motif	0.6871
p.S577F	OVCAR-8	ovary	COSMIC	VSSTPAAT	DEG_SCF_FBW7_1	576:583	Mutation altering degron motif	0.6871
p.R592W	CTV-1	haematopoietic and lymphoid tissue	COSMIC	VSSTPAAT	DEG_SCF_FBW7_1	576:583	Mutation rewiring degron network	0.0833
p.R592W	CTV-1	haematopoietic and lymphoid tissue	COSMIC	AATST	DEG_SPOP_SBC_1	581:585	Mutation rewiring degron network	0.1389
p.R491H	LN-405	central nervous system	COSMIC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	474:485	Mutation rewiring degron network	0.1667
p.V581I	HCT-15	large intestine	COSMIC	VSSTPAAT	DEG_SCF_FBW7_1	576:583	Mutation altering degron motif	0.7076
p.V581I	HCT-15	large intestine	COSMIC	AATST	DEG_SPOP_SBC_1	581:585	Mutation altering degron motif	0.7076
p.N464K	HCC2998	large intestine	COSMIC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	474:485	Mutation rewiring degron network	0.0556
p.V586I	HCT-15	large intestine	COSMIC	VSSTPAAT	DEG_SCF_FBW7_1	576:583	Mutation rewiring degron network	0.25
p.V586I	HCT-15	large intestine	COSMIC	AATST	DEG_SPOP_SBC_1	581:585	Mutation rewiring degron network	0.3056
p.N492K	HCC2998	large intestine	COSMIC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	474:485	Mutation rewiring degron network	0.1389
p.R593P	H513	pleura	COSMIC	VSSTPAAT	DEG_SCF_FBW7_1	576:583	Mutation rewiring degron network	0.0556
p.R593P	H513	pleura	COSMIC	AATST	DEG_SPOP_SBC_1	581:585	Mutation rewiring degron network	0.1111
p.S476F	CAL-62	thyroid	COSMIC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	474:485	Mutation altering degron motif	0.7982
p.S476F	OVCAR-8	ovary	COSMIC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	474:485	Mutation altering degron motif	0.7982
p.H589N	WM793B	skin	COSMIC	VSSTPAAT	DEG_SCF_FBW7_1	576:583	Mutation rewiring degron network	0.1667
p.H589N	WM793B	skin	COSMIC	AATST	DEG_SPOP_SBC_1	581:585	Mutation rewiring degron network	0.2222
p.E180Q	AN3-CA	endometrium	COSMIC	ARTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.1944
p.R574P	H513	pleura	COSMIC	VSSTPAAT	DEG_SCF_FBW7_1	576:583	Mutation rewiring degron network	0.2778
p.R574P	H513	pleura	COSMIC	AATST	DEG_SPOP_SBC_1	581:585	Mutation rewiring degron network	0.1389
p.R470H	LN-405	central nervous system	COSMIC	LAPEQTPVVVHV	DEG_ODPH_VHL_1	474:485	Mutation rewiring degron network	0.2222
p.Q589R	GR-ST	haematopoietic and lymphoid tissue	COSMIC	VSSTPAAT	DEG_SCF_FBW7_1	576:583	Mutation rewiring degron network	0.1667
p.Q589R	GR-ST	haematopoietic and lymphoid tissue	COSMIC	AATST	DEG_SPOP_SBC_1	581:585	Mutation rewiring degron network	0.2222
p.P180H	REH	haematopoietic and lymphoid tissue	COSMIC	ARTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CIZ1

UniProt ID: Q9ULV3

Entrez ID: 25792

Protein name: Cip1-interacting zinc finger protein (CDKN1A-interacting zinc finger protein 1) (Nuclear protein NP94) (Zinc finger protein 356)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CIZ1 in